Senior Technical Specialist

2 months ago

Saffron Walden, United Kingdom Charles River Laboratories Full time

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

**The Role**:
**Charles River Discovery are excited to be recruiting for a Senior Technical Specialist.**

**You will join our in vitro ADME screening team in our Discovery Sciences division. Based just outside of Cambridge, UK at our Saffron Walden site, individuals would have the opportunity to develop in a fast-paced drug discovery environment.**

**At Charles River we value the contributions individuals bring to the team so whether your focus is in-depth technical skills or as an expert in rapid screening, the varied nature of our work offers opportunities to grow.**

**Sound good?**

**Read on to hear more and see what we offer you**

**What You'll Be Doing**:

- Performance of and troubleshooting a range of ADME assays applied in a rapid turnaround drug discovery screening setting, mainly focusing on: kinetic solubility, microsomal stability, cell permeability.
- Generation of quality scientific data and provision of technical support in the early-stage drug discovery process; contextualising data and making timely decisions to support integrated project teams and external partners.
- Training and mentoring of junior team members to ensure effective team development and a robust succession strategy.
- Development of mid-to-long term CAPEX planning, supporting the introduction and evaluation of new technology.
- Contribute to experimental design, review and continuous scientific improvement processes to increase capabilities and capacity.
- Support multiple project teams and provide expertise to cross-discipline groups across the whole drug discovery spectrum.


**What We offer You**:

- A very comprehensive and competitive salary and benefits package from day one, including a generous pension contribution.
- Private medical Insurance.
- A range of other flexible benefits to suit you.
- The opportunity to gain further industry recognised training and experience within your field.
- The chance to work with state of the art equipment, in well resourced laboratories.
- Leadership and management training, and continued professional development.
- Global opportunities and strong career progression.
- To be able make a difference to health and well being of people.
- Flexible working options including remote options.
- Generous holiday allowance - 34 days inc bank hols and buy an extra 5
- Long service awards.
- One Day Volunteer programme.
- Employee Assistance Program (EAP).
- Mentoring and Sabbatical programmes.
- Bonus scheme.

**Skills and Experience**:

- Extensive in an ADME / DMPK relatable or ADME / DMPK relevant environment.
- Comprehensive troubleshooting and problem-solving skills both technical and scientific.
- A desire to continually improve existing processes to meet new standards or requirements.
- Scrupulous attention to detail; getting it right the first time and quality control are at the heart of what we do.
- An interest in new technologies and how they can be applied to enhance existing in-vitro ADME assays.
- Demonstrated practical experience of some or all of the following ADME assays applied in a rapid turnaround drug discovery setting: kinetic solubility, microsomal stability, cell permeability.
- Hands on experience of LC-MS/MS quantification of small molecules in complex matrices in a drug discovery setting.
- Operation of analytical MS systems including Waters, Agilent and ADDA-Sciex HTMS instruments.
- Experience of liquid handlers such as the Hamilton STAR.
- Strong organisation and time management skills alongside an inbuilt flexibility to adapt to change in a dynamic working environment.
- Excellent communication skills and to be an effective team player, able to collaborate with internal and external colleagues.

**About Discovery

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