Antibody Multi-concept Prompt Learning Intern

2 months ago


Cambridge, United Kingdom AstraZeneca Full time

This project aims to extend recently developed Textual Inversion methods, including the Multi-Concept Prompt Learning (MCPL) framework, from the text-image setting to the protein sequence-structure setting. Textual Inversion [1] learns to represent a concept or style in an image as a new “pseudo-word” in the embedding space of a frozen text-to-image model. These soft embeddings can then be composed into new language prompts and used to generate novel images. MCPL [2] builds on this method to enable simultaneously learning multiple embeddings which represent distinct “concepts,” potentially associated with different parts of an image. We propose modifying this framework to function in the case of proteins and antibodies where the structure pays the role of an image and the sequence plays the role of the text. Using inversion we will invert local structural information to sequence embeddings. This will allow for manipulating and editing a learned sequence embedding and generating an ensemble of structures for regions of interest within an overall structure.

**Key technical skills or xperience required**:

- Experience working with and implementing deep learning models, generative models, eg, diffusion models
- Good Programming skills
- Experience working with PyTorch

**Primary duties of this position**:

- Conduct cutting edge research focused on protein and antibody design, and other problems in drug discovery
- Work closely with AstraZeneca AI/ML scientists and engineers, and other scientists at AZ, to develop new machine learning models

**What are we looking for?**

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. We’re deeply committed to our strategy of being a great place to work. For us, that includes fostering an environment where everyone can be among inclusive, supportive individuals with curious minds.

A company that genuinely follows the science and values individuals at all levels, you’ll be backed and encouraged to speak up, ask questions, and share ideas to push the boundaries of science and continuously learn and explore.

Our purpose is bold and so is our approach. Becoming a more agile and innovative company means building a dynamic, inspiring culture where we celebrate entrepreneurial thinking and act with a sense of urgency. We are courageous, taking risks and learning from both success and failure. We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. When you join us, you will be part of a great place to work; in an environment that energizes and empowers each of us to achieve our goal to develop and deliver medicines.



  • Cambridge, United Kingdom AstraZeneca Full time

    **The AstraZeneca Summer Internship Program**: 10-12-week development experience running through the summer months each year Internships are meant to be a catalyst in helping students gain hands on learning & exposure to the career they’re pursuing. **Internships benefit students by supporting them to**: - Build their professional network. - Gain...


  • Cambridge, United Kingdom Agenus Full time

    Job Brief: Senior RA/Associate Scientist - Protein Expression Description: - Location: Cambridge, UK - Laboratory based role - Permanent position, full or part-time We are looking for a talented lab-based scientist to become a key member of our Protein Science team. You’ll be working as a protein expression scientist specialising in transient mammalian...


  • Cambridge, United Kingdom Abcam Full time

    Company Description For over 20 years, abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective...


  • Cambridge, United Kingdom Abcam Plc Full time

    Company Description For over 20 years, Abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective as...


  • Cambridge, United Kingdom Abcam Plc Full time

    Company Description For over 20 years, Abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective as...


  • Cambridge, United Kingdom Transition Bio Full time

    Transition Bio is an innovative, early-stage biotechnology company with the vision of being the world leader in data-driven discovery, analysis, and modulation of biological condensates. At Transition Bio, multidisciplinary teams with diverse skill sets in molecular biology, biophysics, chemistry, engineering, data science and machine learning work closely...

  • Research Assistant

    4 weeks ago


    Cambridge, United Kingdom University of Cambridge Full time

    Fixed-term: The funds for this post are available for 12 months in the first instance. Applications are invited for an exciting opportunity to join the Sormanni Lab at the Chemistry of Health, to assist in multidisciplinary projects related to computational design and laboratory characterization of antibodies and corresponding targets. The main objective...


  • Cambridge, United Kingdom CliniSciences Group Full time

    This is an excellent opportunity for a motivated and target driven PhD graduate to join a fast growing company with high quality life science products desirable for the research, biotech and diagnostic markets.Dedicated to serving scientists, CliniSciences UK (previously Generon), was founded in the UK in 2001 and now operates internationally, across Europe,...

  • Research Intern

    1 month ago


    Cambridge, United Kingdom Sartorius Full time

    Based at our Cambridge, MA site, as the Research Intern, you will serve as a critical contributor to the development and integration of Sartorius’ emerging technologies for characterization and purification of different types of nanoparticles such as extracellular vesicles and exosomes. These leading-edge platforms will be utilized in basic research as...


  • Cambridge, United Kingdom SoCode Limited Full time

    Breakthrough technology is vital for strengthening the UK’s Defence and Homeland Security. As an AI/ML Engineer Consultant, you will be at the forefront of this innovation race to defend and protect the UK from the latest technological and cyber threats.Your work will have a real-world impact. You will get to explore pioneering concepts by collaborating...


  • Cambridge, United Kingdom VRS Recruitment Full time

    Our client provides expert technical and laboratory support for a broad portfolio of clients in the pharmaceutical development sector. They provide services that aid the development of small & large molecule therapeutics, specifically targeting pre-clinicaland clinical stages of development. To support their ongoing expansion, my client is seeking a...


  • Cambridge, United Kingdom AstraZeneca Full time

    **AstraZeneca** At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of...


  • Cambridge, United Kingdom Abcam Plc Full time

    Job DescriptionTo support our Antibody Development Platform, we now have an opening for a 12-month fixed contract for a Senior Manager of Research Area (RA) Scientists.This role is critical for the management of New Product Development (NPD) antibody pipelines in Cambridge; leading a small team responsible for end-to-end design and management of our RabMab...


  • Cambridge, United Kingdom Abcam Plc Full time

    Job DescriptionTo support our Antibody Development Platform, we now have an opening for a 12-month fixed contract for a Senior Manager of Research Area (RA) Scientists.This role is critical for the management of New Product Development (NPD) antibody pipelines in Cambridge; leading a small team responsible for end-to-end design and management of our RabMab...


  • Cambridge, United Kingdom Abcam Full time

    Company Description For over 20 years, abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective...


  • Cambridge, United Kingdom CliniSciences Group Full time

    This is an excellent opportunity for a motivated and target driven PhD graduate to join a fast growing company with high quality life science products desirable for the research, biotech and diagnostic markets.Check below to see if you have what is needed for this opportunity, and if so, make an application asap.Dedicated to serving scientists, CliniSciences...


  • Cambridge, United Kingdom CliniSciences Group Full time

    Job DescriptionThis is an excellent opportunity for a motivated and target driven PhD graduate to join a fast growing company with high quality life science products desirable for the research, biotech and diagnostic markets.Dedicated to serving scientists, CliniSciences UK (previously Generon), was founded in the UK in 2001 and now operates internationally,...


  • Cambridge, United Kingdom Microsoft Full time

    Microsoft Research, Health Futures (UK), is looking for an innovative, collaborative research intern to work impactful healthcare problem. You can be part of a multi-disciplinary team that values diversity and collaboration, composed of researchers, software developers, user researchers and clinicians. The research will involve state of the art machine...


  • Cambridge, United Kingdom Abcam Full time

    Company Description For over 20 years, Abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective...


  • Cambridge, United Kingdom CliniSciences Group Full time

    This is an excellent opportunity for a motivated and target driven PhD graduate to join a fast growing company with high quality life science products desirable for the research, biotech and diagnostic markets.Dedicated to serving scientists, CliniSciences UK (previously Generon), was founded in the UK in 2001 and now operates internationally, across Europe,...