Senior Ra/associate Scientist

3 weeks ago

Cambridge, United Kingdom Agenus Full time

Job Brief: Senior RA/Associate Scientist - Protein Expression

Description:

- Location: Cambridge, UK
- Laboratory based role
- Permanent position, full or part-time

We are looking for a talented lab-based scientist to become a key member of our Protein Science team. You’ll be working as a protein expression scientist specialising in transient mammalian antibody and target protein production. The Protein Sciences team has a broad remit working closely together to support all aspects of protein production and characterisation to help drive forwards our immuno-oncology drug discovery pipeline. The role will involve making significant contributions to both Protein Sciences and to therapeutic project teams.

As a small dynamic biotech company that works from concept to clinic, Agenus can offer you a unique opportunity to develop personally and professionally. The company uses short, agile timelines to underpin our ability to move rapidly from concept to clinic making Agenus an innovative, fast passed environment.

Key Responsibilities
- You will be a key member of our protein production pipeline, working closely with our DNA and protein purification scientists to turn DNA into protein
- Be responsible for the maintenance of our mammalian expression host cell lines (both CHO and HEK)
- Perform transient expression to produce antibodies, antibody-like formats, and other proteins at various scales (from microtiter plates to multi-litre).
- Evaluate new protein expression technologies, procedures, and technical developments for their suitability for our needs.
- Advance our use of automation.
- Work on the optimisation of protein expression methods to improve expressions at all scales and to make the pipeline as smooth and robust as possible.
- Have a good understanding of company priorities and a flexible approach to changing demands to help the company meet its goals.
- Qualifications and Experience
- Experience in protein expression for drug discovery gained either in academia or industry.
- Knowledge of industry standard mammalian expression systems.
- Excellent communication skills and the ability to communicate across scientific disciplines and to small and large teams.
- Demonstrated ability of planning effective experiments, data analysis and interpretation.
- Experience of troubleshooting expression of challenging proteins.
- A background in therapeutic proteins and knowledge of novel protein modalities (e.g. bispecifics, fusion proteins) is an advantage.
- If required, we can adjust the scope of this role to allow for part-time work - just let us know in your covering letter.

Pay: From £36,000.00 per year

Schedule:

- Monday to Friday

Supplemental pay types:

- Yearly bonus

Ability to commute/relocate:

- Cambridge, CB4 0WG: reliably commute or plan to relocate before starting work (required)

**Experience**:

- protein expression: 1 year (required)

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