Research Associate Ii

4 weeks ago

Edinburgh, United Kingdom Asklepios BioPharmaceutical Full time

Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.

At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.

We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain.

Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:

- Advance innovative science by pushing boundaries.
- Bring transformative therapeutics to patients in need.
- Provide an environment for employees to reach their fullest potential.

Our values:

- Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
- Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
- Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
- Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
- Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

The role:
The role will primarily involve the production and purification of viruses from mammalian cells therefore, experience of manufacturing processes (USP/DSP and QC) would be highly advantageous. Ideally you will have experience of recombinant protein, virus or biologic manufacture in an industrial setting.

Skills and Experience:

- Experience in the manufacture of viruses (AAV preferable), recombinant protein or biologics, cell culture aseptic working techniques is essential
- Knowledge of purification (DSP) and analytics (QC) for bioproducts would be advantageous
- Technical knowledge of molecular biology techniques, such as PCR, cloning, and sequence analysis and manipulation, would be advantageous
- Adept at working with and updating SOPs to produce reproducible results
- Experience of fundamental lab skills; pipetting, aliquoting reagents, media/solution preparation, working in a GLP environment
- Effective written and verbal communication across/between team members and management
- Experience in H&S, COSHH, and Risk Assessments
- Detail-oriented and able to perform precise work
- Effectively manage own time/workload to meet deliverables with mínimal oversight
- ._

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