Bpd, Cell Culture

2 months ago


Cambridge, United Kingdom AstraZeneca Full time

**Description of work/project to be undertaken**:
The Upstream Process Design team is involved in delivering a robust process for the production of therapeutic proteins suitable for both clinic and market supply. A major focus of this work is the optimisation of the cell culture process to support robust cell growth and productivity whilst also maintaining desirable product quality attributes. This project will aid in identifying suitable process conditions that support our CHO cell expression platform and maintain the desired product quality attributes. The student can expect to gain an insight into industrially-relevant development and valuable experience in recombinant protein production in mammalian cells including general mammalian cell culture techniques, high throughput cell culture screening in shake flasks and/or ambr micro-bioreactors and possibly experience using bench scale bioreactors.

**Primary duties of this position**:
Gain experience in the following: general mammalian cell culture techniques, high throughput cell culture screening in shake flasks and/or ambr micro-bioreactors and possibly experience using bench scale bioreactors.

Attend and engage in department /team meetings, with opportunity to present.

Plan and execute experiments, including relevant literature reviews. Analyse data and write-up experiments in electronic lab notebook.

Present findings, summarise outcomes and share future recommendations.

**What are we looking for?**

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. We’re deeply committed to our strategy of being a great place to work. For us, that includes fostering an environment where everyone can be among inclusive, supportive individuals with curious minds.

A company that genuinely follows the science and values individuals at all levels, you’ll be backed and encouraged to speak up, ask questions, and share ideas to push the boundaries of science and continuously learn and explore.

Our purpose is bold and so is our approach. Becoming a more agile and innovative company means building a dynamic, inspiring culture where we celebrate entrepreneurial thinking and act with a sense of urgency. We are courageous, taking risks and learning from both success and failure. We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. When you join us, you will be part of a great place to work; in an environment that energizes and empowers each of us to achieve our goal to develop and deliver medicines.


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