Associate Principal Scientist

We offer:

- **Vibrant and dynamic employment - **we are a highly specialised, growth company operating in a critical sector of the economy - our future is strong and exciting
- **Opportunities to develop your skills and yourself - **our rapid growth brings greater opportunities for you to learn and grow faster
- **A great team where we all support each other - **enjoy your work - after all you spend about a third of your time here

**Our Company**:"We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world's leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges".

We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.

We are based in Hertfordshire, in the town of Hoddesdon. The Hoddesdon campus, consisting of several purpose built scientific and administrative buildings together with a purpose built conference STE area has more than 5,000m2 of premier R&D space and houses an established Process Chemistry, Analytical Chemistry and Drug Discovery team, and a newly formed Formulation Development department. The Hoddesdon site has state-of-the-art Good Manufacturing Practice (GMP) standard facilities for the development of Active Pharmaceutical Ingredients (API), formulation development and process chemistry. We offer our employees a highly supportive team-work environment, enabling them to develop and liberate their true potential.

**Pharmaron Drug Discovery**

**Job Title: Associate Principal Scientist - Medicinal Chemistry**

**Job Summary**

With a rapidly expanding department and portfolio the Medicinal Chemistry function is seeking individuals who have a passion for leading Medicinal Chemistry science in discovery projects and who can strengthen the capabilities of our research teams.

This is a rare and exciting opportunity for an inspiring, experienced and forward-thinking Medicinal Chemistry Leader to provide effective medicinal chemistry expertise and leadership of integrated small molecule drug discovery program to enhance the scientific reputation and business performance of Pharmaron. To develop and support a culture of respected science, best scientific practice, knowledge expansion and sharing.

The **Associate Principal Scientist - Medicinal Chemistry** role will provide medicinal chemistry project support, logistics and leadership for client projects.

**Key Roles and Responsibilities**:

- Design and coordinate core experiments with laboratory teams, interpret results, and plan additional experiments in a timely manner to solve assigned problems of high complexity.
- Use expertise to trouble shoot synthetic issues in collaboration with UK or China based synthetic chemists.
- When required by the project, design and execute synthetic chemistry experiments, interpret results, and plan additional experiments in a timely manner to solve problems of high complexity leading to the preparation of the desired target molecules.
- Actively participate in the identification and implementation of new technologies or methodologies, as appropriate within functional area, maintaining continuous improvement in function and teamwork processes.
- Effectively communicate, coordinate and collaborate with clients and cross-functional project groups to ensure that scientific work is appropriately documented via presentations both internally and externally to the client.

**Qualification**
- PhD degree in the area of Organic / Medicinal Chemistry or equivalent industrial experience
- Multi-year experience of working in medicinal chemistry gained in academia, Pharma/Biotech and/or CROs.
- Technically expert and able to work autonomously within area of expertise with a strong project delivery focus.
- Experience of both hit to lead and lead optimisation phases of compound development would be advantageous
- Excellent knowledge of medicinal and synthetic organic chemistry, and working knowledge of DMPK/ADME assays and parameters.
- Organizes and directs own and supervises team efforts, where appropriate.
- Able to critically review relevant scientific literature and assess patent literature, to ensure compounds are novel, and have freedom to operate, and relevant flowcharts are in place.
- Familiarity with the use of industry standard IT tools, data analysis and chemistry software packages.
- Demonstrates constant client orientation and focus, developing effective working relationships with client and customers to enable efficient project progression, responding in a timely manner to all enquiries.
- Anticipates and handles critical situations, taking into account all positions and viewpoints through open communication and being receptive to different or innovative v