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Research Assistant/associate
4 months ago
**Salary**:
**Research Assistant**: £31,396 - £32,982 per annum
**Research Associate**: £33,966 - £44,263 per annum
Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
**Closing Date**: 19 June 2024
The Role
We are looking for a dynamic and knowledgeable researcher with a background in musculoskeletal research. You will drive an independent research project to characterise the role of collagen glycosylating enzymes in chondrocyte and cartilage health. This variant-to-function project will illuminate novel disease mechanisms.
Osteoarthritis (OA) is a chronic disease affecting the joints. Characterised by the breakdown of articular cartilage, this debilitating disease affects ~10 million older adults in the UK. There are currently no disease-modifying pharmacological interventions for OA, yet genome-wide association studies (GWAS) have identified >100 genetic loci that harbour OA risk genes.
One such locus maps to the gene COLGALT2 on chromosome 1. COLGALT2 encodes an enzyme essential for the glycosylation of collagens, which comprise 80% of the dry weight of the cartilage extracellular matrix (ECM). Multiple independent OA risk alleles have been identified which increase the expression of this gene in cartilage. We hypothesise that this results in the overglycosylation of
ECM collagens, reducing their stability and structural integrity.
This project will use both primary and immortalised chondrocytes to determine the impact of knockout and overexpression of COLGALT2 on the chondrocyte phenotype through a combination of histology and proteomics analyses in both primary and immortalised cell lines. Furthermore, you will work to continue our previous investigations on the epigenetic regulation of this gene in specific tissues of the joint through targeted DNA methylation analyses in primary human tissues.
This is a full time, fixed term post for a period of 12 months.
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Key Accountabilities
Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanities
Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
The Person
Knowledge, Skills and Experience
Essential
Ability to work well as part of a team and rapidly acquire new skills
Likelihood of advanced skills directly related to the research projects
High level of analytical and problem-solving capability
Ability to communicate complex information with clarity and to encourage the commitment of others
Experience of research with clear transferable skills and some experience or awareness of the research environment
Presentations at conferences and/or high-quality publications
Desirable
Experience in cell culture and chondrogenesis protocols
Knowledge of epigenetic dataset analyses
Attributes and Behaviours
Enthusiastic, hardworking and able to take initiative
Ability to work independently and as part of a team
Excellent problem solving and analytical skills
Capability to develop new skills
Ability to communicate complex information with clarity and to encourage the commitment of
