Postdoctoral Research Associate

4 weeks ago

Edinburgh, United Kingdom University of Edinburgh Full time

**UE07 - £39,347 - £46,974 per annum**

**School of Biological Sciences - Institute of Quantitative Biology, Biochemistry and Biotechnology**

**Full time - 35 hours per week**

**Fixed term - July 2024 - July 2026
We are looking for a driven and enthusiastic post-doctoral researcher interested in understanding how DNA-and RNA-binding activities of Helix-Turn-Helix transcription factors in an important bacterial pathogen (MRSA) contribute to virulence and host infection.

**The Opportunity**:
We recently found that many Helix-Turn-Helix domain transcription factors (HTH-TFs) from methicillin-resistant _Staphylococcus aureus _also globally bind RNA _in vivo _. Some HTH-TFs have well-established transcriptional roles in regulating MRSA infectivity and antibiotic resistance. Moreover, the transcription activity of numerous HTH-TFs can be controlled by small molecules, making them promising targets for developing novel antimicrobials.

Our data indicate that the regulatory impact of HTH-TFs is much more profound than anticipated, underscoring the need for a thorough characterisation of these proteins. We hypothesise that HTH-TFs post-transcriptionally control a substantial fraction of antibiotic resistance and virulence factors by altering the stability/translation of RNA substrates. RNA may also compete with HTH-TF transcriptional activities.

By integrating state-of-the-art biochemical and phenotypic approaches, you will obtain detailed mechanistic insights into how these RNA-binding activities impact gene expression, and pathogenicity during host infection. A detailed understanding of MRSA HTH-TF function and how its nucleic acid binding is regulated may underpin future therapeutic approaches.

**Your skills and attributes for success**:

- Experience in studying host-pathogen interactions.
- Experience in working with animal infection models.
- Demonstrated background in infection biology.
- Understanding of gene expression regulatory mechanisms.

**Click to view a copy of the full **job description **(opens new browser tab)

**As a valued member of our team you can expect**:
An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits pension scheme **, **staff discounts, family-friendly initiatives, flexible working and much more. Click to access our **staff benefits page **(opens new browser tab) for further information and use our reward calculator to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages **(opens new browser tab).

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