Postdoctoral Research Scientist

4 weeks ago


United Kingdom Earlham Institute Full time

You will need to download, save and complete a copy of the application form using Microsoft Word or preparea copy of your CV that contains all the information requested in the application form.

Applications are invited for a Postdoctoral Research Scientist to join the Research Faculty Department at the Earlham Institute, based in Norwich, UK.

Background:

In humans, over 90% of the variants associated with traits are found within noncoding regions of the genomes, either within genes' introns, untranslated regions, promoters, or within intergenic regulatory regions such as enhancers.

Identifying those functional noncoding sequences and being able to predict the impact of variation within those regions has significant implications. As such, depending on the genetic disorder, between 30% and 70% of the patients do not receive a genetic diagnosis as the likely causative variants fall outside coding sequences.

The recently funded Horizon NextGen consortium encompassing 21 organisations across Europe aiming at developing federated approaches to enable the integration of multimodal and multiomic resources for applications in the areas of cardiovascular medicine.

As part of this highly collaborative project bringing together computer scientists, data scientists, bioinformaticians, clinicians across academia and industry, we are seeking an enthusiastic and ambitious postdoctoral research scientist to undertake computational analysis of the functional implications of variation within noncoding functional sequences in relation to cardiovascular disorders.

As part of the EU Horizon / Innovate UK funded project “Next Generation Tools for Genome-Centric Multimodal Data Integration in Personalised Cardiovascular Medicine” , the role will engage with primary research.

The post holder will work closely with external partners and members of the EU consortium, and will focus on developing machine learning applications to investigate the implications of genetic variation within noncoding functional elements in relation to cardiovascular disorders.

The role:

The post holder will lead on the development and testing to applications to identify noncoding functional elements based on integration of multi-omic data (genome, transcriptome, epigenome) and integrate this novel information in the development of tissue / condition specific regulatory network, with the aim of prioritising variants occurring within those regions based on their predicted impact. They will also lead on the analysis, preparation, and submission of the associated manuscripts.

The successful candidate will develop computational pipelines centered on machine learning applications such as convolutional neural network to reproducibly handle multi-omic data (genome, transcriptome, epigenome) to enable functional sequence annotation, network reconstruction, and the interpretation of the implication of genetic variation within those disorders.

The post holder will have access to cutting-edge high performance computing facilities and expertise. They will join an active community of experimental and computational biologists working on a wide range of genomics analyses. They will also have the opportunity to contribute to other projects at EI.

The ideal candidate:

The successful applicant will have a PhD in bioinformatics, computational genomics or a related subject.

They will have significant experience working with genomic/epigenomic/transcriptomic data, and experience with machine learning applications in genomics investigations. The candidate should have a demonstrable working knowledge of programming languages such as Python, Perl, or R.

Additional information:

Salary on appointment will be within the range £35,300 to £43,750 per annum depending on qualifications and experience. This is a full-time post until 31 December 2027, with a possibility of a 6-month extension.

This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

The closing date for applications will be 11 June 2024.

#J-18808-Ljbffr

  • United Kingdom Findauniversity Ltd. Full time

    MRC Laboratory of Medical Sciences, Medical Research Council MRC Postdoctoral Research Scientist in Medical Image Analysis Computational Cardiac Imaging Group Fixed-Term, 3 years MRC Band 4 Salary: £39,375 plus London allowances (£3,913 & £1,472) per annum* A 3-year postdoctoral position is available at the MRC Laboratory of Medical Sciences...


  • United Kingdom Findauniversity Ltd. Full time

    MRC Laboratory of Medical Sciences, Medical Research Council Deadline: 12 May 2024 MRC Postdoctoral Research Scientist in Medical Image Analysis Computational Cardiac Imaging Group Fixed-Term, 3 years MRC Band 4 Salary: £39,375 plus London allowances (£3,913 & £1,472) per annum* London, UK A 3-year postdoctoral position is available at the MRC...


  • United Kingdom The Earlham Institute Full time

    Hours per week 37 Project Title Next generation tools for genome-centric multimodal data integration in personalised cardiovascular medicine Months Duration 48 Job Description Main Purpose of the Job As part of the EU Horizon / Innovate UK funded project “Next Generation Tools for Genome-Centric Multimodal Data Integration in Personalised...

  • Research Scientist

    4 weeks ago


    United Kingdom Earlham Institute Full time

    You will need to download, save and complete a copy of the application form using Microsoft Word or preparea copy of your CV that contains all the information requested in the application form. Applications are invited for a Postdoctoral Research Scientist to join the Research Faculty Department at the Earlham Institute, based in Norwich, UK. In humans,...


  • United Kingdom IQS Full time

    We are seeking a highly motivated postdoctoral researcher with a PhD degree in Optics, Physics, Soft Materials, or related areas. The postdoctoral researcher must show experience in optical microscopy, data analysis, programming languages (Matlab), and dielectrophoresis. The researcher must show strong interest in research in science in the context of the...


  • United Kingdom Economic and Social Research Council - ESRC Full time

    ESRC invites applications for postdoctoral fellowships (PDF) to be based at accredited ESRC Doctoral Training Partnerships (DTPs). Fellowships are aimed at those in the immediately postdoctoral stage of their career, to provide the opportunity to consolidate their PhD through developing publications, their networks, and their research and professional...

  • Research Scientist

    3 weeks ago


    United Kingdom The Earlham Institute Full time

    Hours per week 37 Project Title Next generation tools for genome-centric multimodal data integration in personalised cardiovascular medicine Months Duration 48 As part of the EU Horizon / Innovate UK funded project “Next Generation Tools for Genome-Centric Multimodal Data Integration in Personalised Cardiovascular Medicine”, the role will engage with...


  • United Kingdom Royal Microscopical Society Full time

    Applications are invited for a Postdoctoral Image Analyst position within the Light Microscopy Facility at the MRC Laboratory of Molecular Biology (LMB), Cambridge. The Light Microscopy Facility at the LMB is a state-of-the-art research resource managing more than 20 advanced microscopy systems. The team offers comprehensive support encompassing all stages...

  • Research Scientist

    1 month ago


    United Kingdom Diageo España SA Full time

    Aarti Calvin | Video | Careers | Diageo plc Meet our People: Aarti Calvin, Senior Liquid Scientist, GB 15 Jan 2023 Hear from Aarti Calvin, a Senior Liquid Scientist within Diageo's European Innovation Research & Development (R&D) team. #J-18808-Ljbffr

  • Postdoctoral Scientist

    12 hours ago


    United Kingdom Newton Colmore Consulting Ltd Full time

    Post-Doc Scientist – High Performance Batteries Post-Doc Scientist – High Performance Batteries Newton Colmore is working with a battery and energy storage technology company in Cambridge and we are assisting them with their search for a post-doc scientist. As a Post-doc Scientist, you will be charged with developing the company’s next generation...

  • Research Scientist

    1 month ago


    United Kingdom Cranleigh Scientific Ltd Full time

    A groundbreaking start-up working on novel DNA/RNA sequencing technology is recruiting a Research Scientist to join its team based in Edinburgh on a permanent basis. The company has just closed out their pre-series A funding round and is investing heavily in all areas of its team as it looks to release its product for clinical studies. You will play a...

  • Research Scientist

    1 month ago


    United Kingdom Amazon Full time

    Job ID: 2588378 | Evi Technologies Limited Our team undertakes research together with multiple organizations to advance the state-of-the-art in speech technologies. We not only work on giving Alexa, the ground-breaking service that powers Echo, her voice, but we also develop cutting-edge technologies with Amazon Studios, the provider of original content...


  • United Kingdom MMR Research Full time

    Or, are you a Graduate looking to kick start your journey in stats? We are open to bringing on board either a Junior Statistician or someone who has a 1-2 years experience and is looking for the next step in their career. MMR is an independent, global consumer and sensory research agency specialising in food, drink, personal and household care research....

  • Research Scientist

    2 weeks ago


    United Kingdom Certara Full time

    Overview We have an immediate opening for a Research Scientist / Senior Research scientist with a background in paediatric Pharmacokinetics. The candidate should have working familiarity wit h physiologically based pharmacokinetic modelling. The successful candidate will join an internationally recognised, multidisciplinary research team, providing...


  • United Kingdom Metrion Biosciences Ltd. Full time

    Research Associate Scientist/Scientist I Metrion Biosciences (‘Metrion’) is a UK-based, ion channel focused Contract Research Organisation (CRO) providing high-quality in vitro preclinical drug discovery and safety profiling services. customer base who access our comprehensive suite of drug discovery services; medicinal chemistry screening support,...


  • United Kingdom College of William & Mary Full time

    Postdoctoral Research Associate of Physics (Experimental Plasma) Please see Special Instructions for more details. Applicants must apply online at Submit a curriculum vitae, a cover letter, a statement of teaching interest and statement of research interests. A diversity statement is not required. Candidates are encouraged to reflect on their past...


  • United Kingdom Instil Bio, Inc. Full time

    Would you like to apply your expertise to the development and manufacture of life changing medicines in a company that follows the science to achieve life changing outcomes to cancer patients? Instil Bio is a science driven dynamic cell therapy company on the frontier of revolutionising cancer treatment. We are changing the course of medicine, drawing on our...


  • United Kingdom Advance Africa Ltd Full time

    KEMRI Principal Clinical Research Scientist Jobs in Kenya KEMRI Principal Clinical Research Scientist Jobs in Kenya KEMRI Principal Clinical Research Scientist Jobs in Kenya KEMRI Principal Clinical Research Scientist Jobs in Kenya The officer will be based at the Malaria Division of KEMRI’s Centre for Global Health Research in Kisumu, western...


  • United Kingdom Scholarshipscafe Full time

    Postdoctoral Fellowship Competition, Scottish Graduate School of Social Science, United Kingdom The Scottish Graduate School of Social Science is excited to announce the initiation of the 2023/24 ESRC Postdoctoral Fellowship Competition. This prestigious fellowship provides a unique opportunity for postdoctoral researchers to advance their career in social...

  • Research Scientist

    1 month ago


    United Kingdom BioIndustry Association Full time

    BioDivide Limited is a cell therapy and advanced biologics company with laboratories based in the South-West, United Kingdom. They are hiring a full-time Research Scientist to support research and process development. Role overview You will carry out a range of research-related and process development activities as well as maintain both GMP-regulated and...