Scientist/Senior Scientist
3 weeks ago
This is an exciting opportunity to be part of a dynamic team of experienced drug discoverers and target protein degradation experts in a brand-new research facility.
We are looking for a highly motivated individual to support our Leukaemia project. Using your expertise and understanding of leukemic disease biology to develop and run in vitro and cell-based assays to understand the impact of degraders on processes including normal haematopoiesis, differentiation and leukemic stem cell function.
This predominantly lab-based role will give candidates experience of working in a multi-disciplinary team in a drug discovery setting as we advance projects to the clinic.
Design, conduct and analyse flow cytometry datasets to build the understanding of the impact of Amphista molecules on AML pathway biology, leveraging both in-house and CRO capabilities
~ Designing, performing and interpreting cell biology and mechanism-of-action studies such as flow cytometry (markers of AML differentiation, leukemic stem cell function and normal haematopoiesis), proliferation assays, immunofluorescence assays to determine levels of degradation associated with changes to cell function.
~ Contribute to the translation biology strategy building the understanding of how degraders can be effective therapies in AML.
~ Keep abreast of current literature on cutting edge techniques in the field
PhD in Cell Biology, Pharmacology or related field
~ Evidence of significant scientific productivity and impact through your own personal contributions to projects, including directing discrete work packages
~ Demonstrated excellence in independently planning and executing experiments as well as critical data analysis skills.
~ This is a 12 month maternity cover role on a fixed term contract.
Competitive salary
~Flexible benefits package which include:
~ Holiday purchase scheme (up to 10 days per year)
~5% Employer pension contribution
~ Critical Illness Cover
~ Health Cash Plan
~ Life Assurance
~ Social events
~ Discretionary bonus
We have a range of projects in the discovery phase, initially focused on oncology with potential to expand into other therapy areas. The Amphista team contains a wide range of experienced drug discovery experts across both biology and chemistry disciplines, creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradation-based drug discovery to develop first-in-class medicines to treat cancer and other areas of high unmet medical need.
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