Senior Scientist

1 month ago

Slough Berkshire, United Kingdom ROYAL SOCIETY OF CHEMISTRY Full time

Job Title: Senior Scientist - Global Biopharmaceutical

Contract: 12 month contract

Location: Slough

Salary: £28.09 - £33.58 PAYE

SRG are working with a Global Biopharmaceutical company to help them find a Senior Scientist to join their busy team. This is an exciting opportunity for an individual experienced in protein analysis.

You will be part of the Protein Production Group playing a key role in project success by generating high quality protein reagents in a timely manner. You will also assist with antibody discovery.

The successful candidate will have the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.

Key Responsibilities will include:
  • You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB's novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.
  • You will have an excellent and proven track record of protein reagent delivery.
  • You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
  • You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.


Candidate Requirements:
  • Candidates will have extensive experience (PhD holder or graduate with 4-5 years) in protein biochemistry, focusing on recombinant protein production.
  • Molecular Biology (DNA manipulation techniques and comprehensive knowledge and experience with software used in manipulating protein and DNA sequences (VNTI) and molecular visualisation of proteins (PyMOL or similar).
  • Proficient in E.coli, insect and mammalian cell expression systems (and experience in 15N, 13C and 2H labelled expression in E.coli)
  • Fully independent in protein purification techniques (affinity, ion exchange, hydrophobic interaction chromatography, size exclusion chromatography, analytical SEC, UV-Vis spectroscopy, and protein refolding techniques) and extensive experience working with AKTA purification platforms and associated software.
  • Fully competent in protein characterisation techniques: SDS-PAGE, Western blot, analytical SEC, UV-Vis spectroscopy and UPLC.
  • Excellent biochemistry knowledge with hands on experience of protein labelling and characterisation.
  • Good understanding of recombinant protein expression systems and the molecular biology involved in generating expression constructs.
  • Thorough knowledge of the latest technologies involved in protein purification.
  • Track record of recombinant protein production covering multiple protein classes including enzymes, structural proteins, cell signalling factors, cell surface receptors and their ligands produced as intracellular and secreted proteins.
  • Ability to work on several projects and conduct experiments in parallel.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy. #J-18808-Ljbffr

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