Assistant Research Associate
3 weeks ago
Research Assistant – (24P-47) The Pirbright Institute
Fixed-Term Contract Until 31/08/2025
The Pirbright Institute delivers world-leading research to understand, predict, detect, and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds, and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; We will produce viral-vectored vaccines expressing NP+M1 with NA and test the protective efficacy of different routes of immunisation in influenza-exposed pigs, to mimic the effect of human pre-exposure to influenza virus. We will study T and B cell responses in detail in different tissues to determine the effect of route of vaccination and attempt to identify correlates of protection. Pigs are genetically, immunologically, physiologically, and anatomically more like humans than small animals and an excellent model for human influenza. The project will require a scientist with training in a wide range of immunological and virological techniques such as FACS analysis, ELISA, ELISPOT, microneutralisation, virus propagation and plaque assays.
This project represents an exciting opportunity to be part of a consortium comprising the Pandemic Sciences Institute, University of Oxford, the Francis Crick Institute, and the Pirbright Institutes carrying out One Health research. It is suitable for virologists and/or immunologists with a keen interest in translational research for human and animal health. Responsible for conducting research into transmission, evolution, and immunity to swine influenza viruses:
Analysis of B and T cell responses after influenza infection and/or immunisation (T and B cell ELISPOT, Flow cytometry, cell proliferation).
Contribute to animal studies to evaluate properties of transmission blockers.
Responsible for working as part of a research team, which will include:
Communicating progress and data, including presentations at internal / external meetings.
Developing and maintaining documentation associated with the health, safety, and biosecurity of the research to preserve a safe working environment.
Assist with lab management (ordering, looking after equipment, sample inventories)
Perform outreach duties.
Time management, reliability under pressure, decision making/problem solving skills, action-oriented, entrepreneurial, agile, ethical/credible, inspiring, creative, influential, collaborative, emotionally intelligent, diplomatic, results driven, passionate, engaging and recognising.
Relevant Life science degree as a minimum (MSc, Master or higher) in Molecular Biology, Virology, Immunology, or other science related field
Previous experience in immunology and/or virology research.
Give meticulous attention to detail including the management of samples and recording of data.
Experience of flow cytometry and other immunological or molecular biology techniques.
Experience of working in a laboratory environment.
Evidence of networking skills with the ability to build effective collaborative relationships.
Computer literate with a good knowledge of different computer programs and experience in data presentation.
Due to the nature of the work carried out by Pirbright, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.
Generous Group Personal Pension Scheme and life cover (subject to age and earnings).
~25 days annual leave per annum, pro rata, plus 10.Buy and sell annual leave.
~ Option to carry over up to two weeks annual leave.
~ Pirbright gym with subsidised membership.
~ Pirbright Lifestyle Hub (employee discount site).
~ Cycle to work.
~ Childcare allowance.
~ Free onsite parking.
~ Electric car charging facilities.
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