Senior Scientist, Vector Development

2 weeks ago

United Kingdom Adaptimmune Therapeutics PLC Full time
Abingdon, Oxfordshire, United Kingdom - Full Time

Adaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate operations.

Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.

Primary Responsibility

Functional focus: The Vector Process and Analytical Development team is responsible for developing, characterising vector manufacture to support Adaptimmune’s cell based drug product manufacture.
The purpose of this role is to lead and provide technical expertise on cross-functional projects including process improvement, technology transfer and late phase development activities, such as support IND submissions. The candidate will be expected to design, execute and analyse experiments in the laboratory within a team setting. The Senior Scientist will coordinate and drive the progression of project work streams to solve complex problems and/or troubleshoot existing processes within dedicated teams. They will be expected to contribute to late phase development projects, supporting IND submissions and Biological Licence Applications.
The Senior Scientist will be relatively independent in the planning, execution and analysis of their experiments. The Senior Scientist will work closely with the team leadership to ensure a cohesive workstream strategy and alignment to project delivery.
This role will require the supervision/mentorship of other junior scientists in a matrixed manner within the team, working closely with their line managers. There is a requirement of this Senior Scientist role to involve project work-stream leadership and management.
Performance in this role (including functional and project objectives and behaviours) will be monitored through group performance and stakeholder feedback from peers, senior management and workstream team members.

Key Responsibilities
  • In partnership with the Director/Associate Director/Principal Scientist, designing and conducting experiments appropriate for the individual function and/or discipline to enable group and/or project objectives.
  • Analyse, summarise, record and communicate experimental results.
  • Active participation in group and project meetings and discussions.
  • Supervision/mentorship of other junior scientists, and project work-stream leadership/management
  • Contribute to routine lab maintenance
Qualifications & Experience

Required
  • Degree in Biological Sciences
  • Relevant post-graduate experience within academic or industry setting.
  •  Ability to work independently on routine experiments, after training.
  • Ability to learn and develop to work independently on complex experiments within a reasonable time frame.
  • Late phase development activities e.g. characterisation and scale down model qualification.
Desirable
  • Tech transfer of vector manufacturing processes
  • Practical experience in vector analytical assays.
  • Practical experience of vector processing techniques.
  • GMP experience.
  • Scientific project and/or people leadership experience.
  • Experience of implementation of CMC and Regulatory requirements for viral vector manufacture in cell/gene therapy.
other requirements
  • Occasional travel for tech transfer purposes may be required.

 

At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

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