Current jobs related to Computational Chemist - Cambridge - Bicycle Therapeutics
-
Senior Computational Chemist
1 week ago
Cambridge, Cambridgeshire, United Kingdom Rowland Talent Solutions Full timeJob DescriptionWe are seeking a highly skilled Computational Chemist to lead our computational chemistry department and provide solutions to complex drug discovery problems.The role:As a Computational Chemist - Team Leader, you will be responsible for delivering drug discovery projects using a suite of software tools.You will work collaboratively with the...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeComputational Chemist OpportunityWe are seeking a highly motivated and experienced computational chemist to join our team at SLS Services Limited. As a computational chemist, you will play a key role in supporting our drug discovery pipeline by providing expertise in computational chemistry and developing tools and workflows to extract, integrate, and...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeComputational Chemist OpportunityWe are seeking a highly motivated and experienced computational chemist to join our team at SLS Services Limited. As a computational chemist, you will play a key role in supporting our drug discovery pipeline by providing expertise in computational chemistry and developing tools and workflows to extract, integrate, and...
-
Computational Chemist
3 weeks ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeJob Title: Computational Chemist - Drug DiscoveryWe are seeking a highly motivated and experienced computational chemist to join our team at SLS Services Limited. As a computational chemist, you will play a key role in our drug discovery pipeline, working closely with cross-functional teams to develop and implement computational chemistry technologies.Key...
-
Computational Chemist
3 weeks ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeJob Title: Computational Chemist - Drug DiscoveryWe are seeking a highly motivated and experienced computational chemist to join our team at SLS Services Limited. As a computational chemist, you will play a key role in our drug discovery pipeline, working closely with cross-functional teams to develop and implement computational chemistry technologies.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly motivated and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly motivated and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly motivated and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly motivated and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly skilled and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
1 month ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly skilled and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
3 weeks ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly skilled and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
3 weeks ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeSenior Computational ChemistWe are seeking a highly skilled and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will be responsible for providing computational chemistry expertise to support the development of novel medicines for underserved diseases.Key...
-
Computational Chemist
5 days ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeWe are seeking an experienced computational chemist to join our team in the pharmaceutical industry. The successful candidate will possess strong expertise in various techniques including virtual screening, molecular dynamics, and applying machine learning models to analyse and interpret project data.This is a clinical-stage biopharmaceutical company...
-
Senior Computational Chemist
2 weeks ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeWe are seeking a highly motivated and experienced Senior Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to support our projects.Key responsibilities include:Providing computational chemistry expertise to cross-functional...
-
Computational Chemistry Team Leader
1 month ago
Cambridge, United Kingdom Rowland Talent Solutions Full timeAre you a Computational Chemist looking for the next step in your career?Then we currently have a fantastic opportunity for a Computational Chemistry Team Leader to join a drug discovery company in the South East.The role:As a Computational Chemist - Team Leader, you will lead the computational Chemistry department to provide solutions to a range of complex...
-
Computational Chemist
2 months ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeAbout the RoleWe are seeking a highly skilled and experienced Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will play a critical role in the development of novel medicines for underserved diseases.Key ResponsibilitiesContribute to the design, development, and optimization of small molecule...
-
Computational Chemist
2 months ago
Cambridge, Cambridgeshire, United Kingdom SLS Services Limited Full timeAbout the RoleWe are seeking a highly skilled and experienced Computational Chemist to join our team at SLS Services Limited. As a key member of our drug discovery team, you will play a critical role in the development of novel medicines for underserved diseases.Key ResponsibilitiesContribute to the design, development, and optimization of small molecule...
-
Head of Computational Chemistry
4 weeks ago
Cambridge, Cambridgeshire, United Kingdom CK Group Full timeLead Computational Chemistry Team at Nxera PharmaWe are seeking an exceptional computational chemist and drug hunter to lead the Computational Chemistry team at Nxera Pharma.This is an exciting opportunity to leverage the NxWave platform and lead the application of computational approaches in drug discovery projects, developing novel methodologies for wider...
-
Head of Computational Chemistry
4 weeks ago
Cambridge, Cambridgeshire, United Kingdom CK Group Full timeLead Computational Chemistry Team at Nxera PharmaWe are seeking an exceptional computational chemist and drug hunter to lead the Computational Chemistry team at Nxera Pharma.This is an exciting opportunity to leverage the NxWave platform and lead the application of computational approaches in drug discovery projects, developing novel methodologies for wider...
Computational Chemist
2 months ago
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can't change the world if you don't have determination
- We are One Team. We only succeed when we work together.
Check below to see if you have what is needed for this opportunity, and if so, make an application asap.
We are looking for a computational chemist with experience in various techniques including virtual screening, molecular dynamics and applying machine learning (ML) models to analyse and interpret a broad spectrum of project data.
You will join a highly collaborative environment and work with multiple teams, both UK and US based, within our drug discovery pipeline. You will will be highly-motivated, self-starting and ambitious.
Key responsibilities
- You will be involved in multiple projects drawn from a range of therapeutic areas and at different stages from initial hit identification to lead optimisation
- Responsible for providing computational chemistry expertise to cross-functional teams to support drug discovery projects.
- Contribute to the ongoing development of computational chemistry technologies for drug discovery within the company
- Developing and implementing tools and workflows to extract, integrate, analyse and visualise chemical, biophysical and ADMET data to support our various project decision making processes
- Support and train members of the discovery teams in the use of analysis and visualisation tools and other aspects of computational chemistry
Essential:
- Industry experience, or post doctorial experience in computational chemistry
- Practical knowledge of conducting and analysis of molecular dynamics (MD) simulations using standard software such as OpenMM, AMBER and/or GROMACS, etc
- Experience in QSAR virtual screening, ideally with peptides
- Experience in writing analysis scripts and pipelines in common scripting languages, such as python, in Jupyter notebooks or as standalone scripts.
- Experience in amino acid and peptide modelling
- Practical knowledge of Free Energy Perturbation (FEP) calculations
- Use of HPC
Desirable:
- Knowledge of cheminformatics methods and databases
- Practical knowledge of quantum mechanical calculations (QM)
- Skills in machine learning, deep learning, statistical modelling and advanced data analytics
- Experience in drug discovery organisation(s)
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover.
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
