Principal Scientist, Genomic Technologies, Human Genetics and Genomics

We are seeking an innovative scientist to join our team. The successful candidate will join the Genomic Technologies team within the Human Genetics and Genomics (HGG) the Genomic Technologies group we integrate deep and broad expertise in computational and statistical methods and techniques to enable best-in-class analytical insight and interpretation of genetics and genomics data to guide GSKs drug discovery and development portfolio and pipeline decisions.The successful candidate will join an existing Statistical Genetics team and will work on projects aligned to current areas of focus including:Discovery of new causal gene-phenotype links through analysis of large-scale individual level human genetic data.Identification of causal genes disease-relevant mechanisms and cell types potential drug targets candidate biomarkers patient subgroups and disease subtypes through integration of genetic association data across multiple omic and phenotypic layers.Predictive modelling of presence direction and magnitude of causal gene-phenotype links using genetic and omic data mechanistic annotation inferred causal networks and genome-scale perturbation data.At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples lives. GSK fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.Find out more:Our approach to R&DIn this role you will:Evaluate improve test and develop production implementations of best-in-class methods for analysis of genetic data in collaboration with scientists in Data and Predictive Sciences Biostatistics or/and AI/ML teams.Generate large-scale analysis outputs and/or implement state-of-the-art tools for dynamically analysing interpreting and visualizing genetic and genomic data.Collaborate with partners in applied and translational teams across HGG in experimental Target Discovery and in GSK disease area Research Units to influence portfolio and pipeline decisions.Stay informed about recent research in the field and consider its potential for application within GSK.Contribute to a culture of innovation quality and willingness to learn and improve.Why youQualifications & Skills:We are looking for a professional with these required skills to achieve our goals:Advanced degree (PhD or equivalent) in a relevant scientific discipline.Experience working with large scale biobank data such as UK Biobank and All of Us.Excellent programming skills in R or python and application of techniques in reproducible research literate programming FAIR data principles or software development.Experience of evaluating improving testing and/or developing methods for analysis and interpretation of large-scale genetics data.Strong communication and team-working skills.Preferred Qualifications & Skills:If you have the following characteristics it would be a plus:Deep understanding of statistical genetics methodology.Experience working in cloud-based Trusted Research Environments.Experience with machine learning and/or advanced statistical methods.Experience working in multidisciplinary teams on complex and impactful projects.Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g. SQL PySpark BigQuery Docker Nextflow).This position may be based at a GSK R&D site in UK (Stevenage) in USA (Cambridge Tech Square MA; or Upper Providence PA) or in Germany (Heidelberg).#HGGClosing Date for Applications: 24th October 2025Please take a copy of the Job Description as this will not be available post closure of the advert.When applying for this role please use the cover letter of the online application and your CV to describe how you meet the competencies for this role as outlined in the job requirements above. We encourage applicants to describe in their cover letter how their qualifications skills and experience would make them outstanding contributors to the work of Genomic Technologies and of HGG.The information that you have provided in your cover letter and CV will be used to assess your application.Why GSKUniting science technology and talent to get ahead of disease together.GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.We believe in an agile working culture for all our roles. 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GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license GSK may be required to capture and report expenses GSK incurs on your behalf in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSKs compliance to all federal and state US Transparency requirements. For more information please visit the Centers for Medicare and Medicaid Services (CMS) website at Experience:Staff IC Key Skills Machine Learning,Python,Data Science,AI,R,Research Experience,Sensors,Drug Discovery,Research & Development,Natural Language Processing,Data Analysis Skills,Toxicology Experience Employment Type : Full-Time Experience: years Vacancy: 1