Research Associate in Genetic Design and Assembly for Gene Therapy

4 weeks ago

London, Greater London, United Kingdom Imperial College London Full time

Location: South Kensington Campus

Job Summary

We are pleased to announce the opening of the above post, following our recent UKRI award which is part of a £14.2m Engineered Genetic Control Systems for Advanced Therapeutics Mission Hub, led by the University of Edinburgh. As part of this award, we are looking for a candidate to help us to build and test new methods for engineering AAVs for therapeutic applications.

Applications are therefore invited for a Research Associate to join the Department of Life Sciences at Imperial College London. You will work closely with members of Professor Geoff Baldwin's Group ). You will be based in Sir Alexander Fleming Building (SAF), South Kensington Campus.

Candidates should be able to start work on 13 May 2024, or as soon as possible after.

Specifically, we are looking for someone experienced in synthetic biology approaches to DNA assembly and protein biochemistry (including protein expression in E. coli, purification and ELISA assays). Experience in mammalian AAV expression and AAV delivery in vivo would be welcome but is not essential.

Duties and responsibilities

In this role you will be expected to perform experiments to a high standard.

Your key responsibilities will be to:

  • Assembling DNA expression constructs
  • Perform molecular biology techniques including design and molecular cloning of multi-gene cassettes, mutagenesis, PCR and DNA sequencing
  • Express and purify proteins
  • Develop assays to evaluate AAV particle assembly and packaging
  • Present data for interpretation by others.
  • Ensure the validity and reliability of data at all times
  • Present findings to colleagues, consortium partner meetings and at conferences
  • Write up the finding for submission to refereed journals
  • Take responsibility for organising resources and effective decision making in support of research
  • Direct the work of small research teams including undergraduate and postgraduate students

Essential requirements

  • Hold, or be near completion of, a PhD degree (or equivalent) in Biological Sciences or a related field
  • Molecular biology skills (DNA design, cloning, PCR etc.)
  • Protein biochemistry (Protein expression from a range of organisms, purification and analysis)
  • Mammalian cell culture desirable but not essential
  • A creative approach to problem-solving
  • The ability to organise your own work with minimal supervision and prioritise in response to deadlines
  • The ability to supervise others (e.g. Masters and Undergraduate students)
  • Excellent verbal and written communication skills
  • Practical experience within a research environment and publication in relevant and refereed journals

Further Information

This is a full time, fixed-term position until 12 May 2027. You will be based at South Kensington Campus.

Candidates should be able to start work on 13 May 2024, or as soon as possible after.

To apply, please complete an online application.

Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.

For enquires about the position, please contact Professor Geoff Baldwin by email:

£45,593 to £53,630 per annum

  • Senior Laboratory Research Scientist

    2 weeks ago

    London, Greater London, United Kingdom The Francis Crick Institute Full time

    The Human Biology Facility (HBF) provides support and expertise to enable research utilising human materials and data, and to develop capability in core areas relating to stem cells, genetic modification and human model systems. We provide support to Crick researchers, including our growing number of clinical scientists, throughout the study lifecycle...

  • Research Technician

    2 weeks ago

    London, Greater London, United Kingdom UCL Full time

    About usThe Institute of Ophthalmology is committed to a multi-disciplinary research portfolio that furthers an understanding of the eye and visual system linked with clinical investigations targeted to specific problems in the prevention and treatment of eye disease. The combination of the Institute's research resource with the resources of Moorfields Eye...

  • Research Fellow

    3 weeks ago

    London, Greater London, United Kingdom UCL Full time

    About usApplications are invited for the post of Research Fellow at UCL Institute of Ophthalmology, ranked the best place in the world to study Ophthalmology (CWUR Rankings by Subject 2017).The successful candidate will join the newly established research team of Dr Rodrigo Young to investigate the role of genes related to human eye globe defects during...

  • Research Fellow – Functional and Computational Genomics

    1 week ago

    London, Greater London, United Kingdom UCL Full time

    About usBiosciences is one of the world's foremost centres for research and teaching in the biological sciences and one of the largest Divisions within UCL, undertaking a significant amount of research and teaching. The Division has a diverse portfolio addressing all areas of biology from protein interactions to cell function, organism development, genetics,...

  • Research Assistant

    1 week ago

    London, Greater London, United Kingdom UCL Full time

    About usBiosciences is one of the world's foremost centres for research and teaching in the biological sciences and one of the largest Divisions within UCL, undertaking a significant amount of research and teaching. The Division has a diverse portfolio addressing all areas of biology from protein interactions to cell function, organism development, genetics,...

  • Nucleic Acid Therapy Accelerator

    4 weeks ago

    London, Greater London, United Kingdom NATA Full time

    Nucleic Acid Therapy AcceleratorThe Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30M over 5 years to establish the Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid therapeutics. NATA has state of the art...

  • Postdoctoral Research Assistant in Genomics

    2 days ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleWe have an opportunity to join the Centre for Multi-omics, working with some of the world leaders in the genetic discovery of molecular traits, that underlay disease mechanisms. We have unique multi-omic biosample repositories for research from consented patients, and available for longitudinal follow-up, from our culturally-diverse local East...

  • Postdoctoral Researcher

    1 month ago

    London, Greater London, United Kingdom MRC NATA Full time

    Hours: Full time on site – 36 hours per weekContract type: Fixed Term - 23 monthsNucleic Acid Therapy AcceleratorThe Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30M over 5 years to establish the Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research...

  • Research Associate

    21 hours ago

    London, Greater London, United Kingdom ROYAL COLLEGE OF ART Full time

    Founded in 1837, the Royal College of Art is the world's largest community of postgraduate art and design students. It is also the oldest art and design university in continuous operation and has been ranked as the world's number one art and design university for a remarkable ten consecutive years, according to the QS World University Rankings by Subject the...

  • Research Associate

    6 days ago

    London, Greater London, United Kingdom KINGS COLLEGE LONDON Full time

    Job descriptionAIMS-2-TRIALS is the largest autism study in the world, led by the Forensic and Neurodevelopmental Sciences (FANS) department at KCL. We conduct deep phenotyping and drug challenge studies of infants, children and adults to better understand the aetiology, emergence and maintenance of autism and co-occurring conditions, with the aim of...

  • Postdoctoral Research Assistant

    2 hours ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    London £40,223 per annum inclusive of London Allowance. Full Time Fixed-Term/Contract 16th May 2024 25th June 2024 105Applications are invited for a post of Post-Doctoral Research Associate (PDRA) within the William Harvey Research Institute at Bart's and The London Medical School, Queen Mary University of London (QMUL).The candidate will be highly...

  • Research Associate

    3 weeks ago

    London, Greater London, United Kingdom BCNO Group Full time

    Hours: 35 hours pw, full time About UsThe BCNO Group brings together two well-renowned osteopathic educational institutions – the European School of Osteopathy and the British College of Osteopathic Medicine. Our Research team, led by Dr William Gowers, focuses on providing high-quality support for undergraduate and institutional research activities within...

  • Senior Manager, Financial Planning and Analysis

    4 weeks ago

    London, Greater London, United Kingdom Assembly Global Full time

    The Assembly Finance team is seeking a detail oriented and driven Senior manager, FP&A. The Senior manager, FP&A role provides an opportunity partner with key stakeholders across the company. In this position, the Senior manager will Support the Senior Director FP&A with responsibility for ensuring the completeness and integrity of forecasts, budgets,...

  • Research Associate

    3 weeks ago

    London, Greater London, United Kingdom Royal College of Art Full time

    Founded in 1837, the Royal College of Art is the world's largest community of postgraduate art and design students. It is also the oldest art and design university in continuous operation and has been ranked as the world's number one art and design university for a remarkable ten consecutive years, according to the QS World University Rankings by Subject...

  • Quantitative Researcher

    4 weeks ago

    London, Greater London, United Kingdom G-Research Full time

    Do you want to tackle the biggest questions in finance with near infinite compute power at your fingertips?G-Research is a leading quantitative research and technology firm, with offices in London and Dallas. We are proud to employ some of the best people in their field and to nurture their talent in a dynamic, flexible and highly stimulating culture where...

  • Associate Director

    3 days ago

    London, Greater London, United Kingdom JR United Kingdom Full time

    Northreach is a dynamic recruitment agency that connects businesses with top talent in cell & gene therapy. Our mission is to provide a seamless and personalised recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth. We are partnered with a globally market...

  • Research Associate

    3 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleApplications are invited for a fully funded position at the Research Associate level within the Centre for Advanced Robotics (ARQ), School of Engineering and Material Sciences at Queen Mary University of London. The project is funded by NERC, under the supervision of Dr. Ketao Zhang and Dr. Paul Balcombe. The project will investigate...

  • Research Associate in Data Analytics

    4 weeks ago

    London, Greater London, United Kingdom King's College London Full time

    Job descriptionThe primary purpose of the post is to support work for our NIHR HSDR grant, "Improving kidney failure risk calculations in ethnically diverse populations", involving epidemiological data analysis using electronic health records. This will include developing applications of epidemiology to translational medicine and public health. The post...

  • Research Associate

    2 weeks ago

    London, Greater London, United Kingdom King's College London Full time

    Job DescriptionThis is an exciting opportunity for a Research Associate to join a National Institute for Health and Care Research (NIHR) funded project led by a midwifery lecturer/researcher. The post will be based in the Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care.This research study will provide the necessary developmental work...

  • Post-doctoral Research Associate

    6 days ago

    London, Greater London, United Kingdom King's College London Full time

    Job descriptionAIMS-2-TRIALS is the largest autism study in the world, led by the Forensic and Neurodevelopmental Sciences (FANS) department at KCL. We conduct deep phenotyping and drug challenge studies of infants, children and adults to better understand the aetiology, emergence and maintenance of autism and co-occurring conditions, with the aim of...