Postdoctoral Researcher

1 month ago

London, Greater London, United Kingdom MRC NATA Full time

Hours: Full time on site – 36 hours per week

Contract type: Fixed Term - 23 months

Nucleic Acid Therapy Accelerator

The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30M over 5 years to establish the Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid therapeutics. NATA has state of the art chemistry and biology laboratories and capabilities located on the Harwell Research and Innovation Campus, Oxfordshire alongside the MRC Harwell Mary Lyon Centre, National Mouse Genetics Facility.

The Role

We are seeking to appoint a highly motivated and enthusiastic postgraduate scientist to work on a collaborative project between NATA and University College London (UCL). The project aims to develop personalized antisense oligonucleotide (ASO) therapy for beta-propeller protein-associated neurodegeneration (BPAN), a rare early onset disorder affecting neuronal function.

Responsibilities

  • Undertake laboratory experiments as required by the project and analyse/report data (presentations, verbal and written report)
  • Develop monogenetic disease modelling for the evaluation of oligonucleotides
  • Identify, develop and apply different techniques as required to pursue the research objectives
  • Prepare standard protocols for novel methods
  • Ensure all work is carried out in accordance with the host institution's regulations
  • Update co-supervisors in a timely way on any results and prepare research updates regularly
  • Keep excellent scientific records
  • Contribute to the smooth running of the group, including the effective use and management of resources, training of others and taking responsibility for use of communal facilities
  • Enhance your research and generic skills through a tailored development programme
  • Present work internally and at national and international meetings
  • Maintain a good knowledge of the relevant literature and of the wider field and actively promote this to the group
  • Work effectively with collaborators
  • Supervise students, visitors and trainees as necessary on specific projects

Essential selection criteria

  • Hold a relevant Ph.D/D.Phil in biology, pharmacology, toxicology or a related discipline
  • Peer-reviewed research publications commensurate with career stage
  • Background in working on monogenetic disease modelling, in particular, in vitro modelling with hiPSC-derived neurones
  • Experience in reprogramming patient-derived cells into hiPSCs
  • Experience in maintenance and differentiation of PSCs
  • Experience in elucidation of disease mechanisms with standard laboratory techniques (qRT-PCR, Western blotting, confocal microscopy etc)
  • High-level of creativity and independence in developing innovative analysis methods and solving complex problems
  • Experience and knowledge of data analysis and interpretation
  • Experience of managing biology projects and resources
  • Excellent oral and written communication skills
  • Ability to analyse data in the literature and place own work in the context of work in the field
  • Passionate about collaborative working and building relationships to reach common goals
  • High level organisational skills, with the ability to manage a broad range of jobs simultaneously and under pressure
  • Flexible and adaptable, able to manage changing priorities
  • Capable of critical thinking
  • Working and adhering to standard operating procedures and experience of process analysis and refinement
  • Organised, hard-working with a strong eye for detail and able to work as part of a team
  • Demonstrate ability to meet milestones

£39,375 to £41,843 per annum (depending on experience, plus inner London weighting)

  • Postdoctoral Research Associate

    4 days ago

    London, Greater London, United Kingdom King's College London Full time

    Business unit: Natural, Mathematical & Engineering Sci.Contact details: Tim Nott. Location: Guy's Campus. Category: Research.Job descriptionThe Nott group is looking for a skilled and motivated Postdoctoral Research Associate with a strong background in structural biology, cell biology, or biophysics. The project will combine novel methods for studying...

  • Postdoctoral Research Associate

    4 days ago

    London, Greater London, United Kingdom KINGS COLLEGE LONDON Full time

    The Nott group is looking for a skilled and motivated Postdoctoral Research Associate with a strong background in structural biology, cell biology, or biophysics. The project will combine novel methods for studying membraneless organelles with structural strategies for characterising molecular conformations, interactions, and enzyme activity.Applicants...

  • Postdoctoral Research Associate

    1 month ago

    London, Greater London, United Kingdom KINGS COLLEGE LONDON Full time

    We are seeking to appoint a postdoctoral research associate with an excellent track record in knowledge graphs and machine learning. Topics of interest in this area include, but are not limited to: natural language processing, large language models, graph learning, general pre-trained transformers, prompt engineering, knowledge graphs, knowledge...

  • ESRC Postdoctoral Fellowships

    1 month ago

    London, Greater London, United Kingdom Economic and Social Research Council - ESRC Full time

    ESRC invites applications for postdoctoral fellowships (PDF) to be based at accredited ESRC Doctoral Training Partnerships (DTPs).Fellowships are aimed at those in the immediately postdoctoral stage of their career, to provide the opportunity to consolidate their PhD through developing publications, their networks, and their research and professional...

  • Postdoctoral Research Associate

    1 month ago

    London, Greater London, United Kingdom King's College London Full time

    Job descriptionWe are seeking to appoint a postdoctoral research associate with an excellent track record in knowledge graphs and machine learning. Topics of interest in this area include, but are not limited to: natural language processing, large language models, graph learning, general pre-trained transformers, prompt engineering, knowledge graphs,...

  • Postdoctoral Research Associate DERISK

    1 month ago

    London, Greater London, United Kingdom KINGS COLLEGE LONDON Full time

    Job descriptionThe Department of Political Economy is seeking to appoint two Postdoctoral Research Associates to work full time on the research project DERISK with Steven Klein. The Systemic Risk and the Transformation of Democracy (DERISK) project is funded by a UKRI Frontier Research Grant (successfully evaluated for the ERC Starting Grant and funded by...

  • Postdoctoral Research Assistant

    3 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleWe are seeking a Postdoctoral Research Assistant to work on the project "Optimising CO2 Mineralization: From Atomistic Detail to Reactor Design" under the joint supervision of Dr Gregory Chass and Dr Devis Di Tommaso in the School of Physical and Chemical Sciences at Queen Mary University of London (UK).About YouThe ideal candidate should...

  • Postdoctoral Research Fellow

    3 weeks ago

    London, Greater London, United Kingdom UCL Full time

    About usThis is an exciting opportunity for an experienced scientist to join UCL as a Postdoctoral Research Fellow, working in the Laboratory for Molecular Cell Biology, a Division in the Faculty of Life Sciences, ranked No.2 in London and No.9 in the World for Life Sciences and Medicine (QS Rankings by Subject 2023).About the roleThe Acton Lab, funded by...

  • Postdoctoral Research Assistant

    1 month ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleThe Postdoctoral Research Assistant will contribute to the intellectual life of the School / Institute and wider institution. They will be involved in an ESRC-funded study, CREATE (Cultivating REsilience in Adolescents with Trauma-related Emotions). The project aims to co-create a protocol for delivering arts-therapy based groups to children...

  • Postdoctoral Research Assistant

    4 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleApplications are invited for a Postdoctoral Research Assistant (PDRA) to work at the School of Biological and Behavioural Sciences (SBBS) in the research group of Dr. Mario dos Reis, as part of a BBSRC project on development of Bayesian methods to analyse large genomic datasets. We seek a highly motivated individual with relevant background in...

  • Research Assistant or Postdoctoral Research Assistant

    3 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleThe School of Electronic Engineering and Computer Science at Queen Mary University of London is looking to recruit a Research Assistant or Postdoctoral Research Assistant in AI for Music. The Centre for Digital Music has been awarded an Innovate UK grant, collaborating with a pro-audio company. The post-holder will work on lyrics generation...

  • Postdoctoral Research Assistant

    4 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleApplications are invited for a full-time Postdoctoral Research Assistant to investigate mechanical sensing in cardiac muscle cells and its involvement in cardiovascular disease.Cardiovascular diseases are the major cause of mortality worldwide, yet there is still a lack of effective treatments. Recent research increasingly emphasised that...

  • Postdoctoral Research Assistant in Biomechanics

    3 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleWe have an exciting opportunity for an individual to join our team, working in the area of biomechanics. The successful candidate will create numerical models of biomechanical structures and validate them through experimental work. They will write and publish research papers, contribute to research proposals and liaise with medical partners....

  • Postdoctoral Research Assistant

    4 weeks ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleWe are seeking a postdoctoral research assistant to join the group of Dr Mirjana Efremova in the Centre for Genomics and Computational Biology, to work on a CRUK funded project to investigate the role of cell plasticity in metastasis in colorectal cancer. Our lab is focused on understanding the cellular and molecular mechanisms underlying cell...

  • Postdoctoral Research Fellow

    2 days ago

    London, Greater London, United Kingdom London South Bank University Full time

    Turning Passion into Purpose. Applications are invited for a Postdoctoral Research Fellow (PDRF) in Electronic Engineering and Signal Processing with a particular emphasis on hardware and software optimisation for non-ionizing medical devices. This full-time 18-monts post is part of a 48-month prestigious EU project granted in the context of...

  • Postdoctoral Fellow

    4 weeks ago

    London, Greater London, United Kingdom The Francis Crick Institute Full time

    Location: The Francis Crick Institute, Midland Road, LondonShort summary The laboratory of Tumour-Immune Communication has been established in early 2024. We study bidirectional interactions between cancer cells and the host immune system using synthetic and molecular biology, genetics, and immunology.The ProjectThis project is designed to understand the...

  • Postdoctoral Fellow

    1 month ago

    London, Greater London, United Kingdom The Francis Crick Institute Full time

    Location: The Francis Crick Institute, Midland Road, LondonShort summary A potential project is to understand the interplay between cell division and cell identity during human development, reprogramming and disease using hESC and organoid models.In this project, some of the specific aims include but are not limited to:To use genome editing technologies to...

  • Postdoctoral Fellow: Mongol Connections

    4 weeks ago

    London, Greater London, United Kingdom Courtauld Institute of Art, University of London Full time

    The Courtauld is the UK's leading institution for teaching and research in Art History and the conservation of paintings. The Courtauld's Gallery is one of the finest small art museums in the world, which reopened to the public in November 2021 following a major transformation. Across its two academic departments, History of Art and Conservation, it offers...

  • Postdoctoral Research Assistant

    1 month ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the roleAn exciting opportunity to join the Ciccarelli lab ) to study the drivers of cancer evolution, from its early appearance to its response to therapy. We are a multidisciplinary team combining computational and wet-lab approaches and are affiliated with the Francis Crick Institute, a pioneering biomedical research institute in London.We are...

  • Postdoctoral Research Assistant in Genomics

    5 days ago

    London, Greater London, United Kingdom Queen Mary University of London Full time

    About the RoleWe have an opportunity to join the Centre for Multi-omics, working with some of the world leaders in the genetic discovery of molecular traits, that underlay disease mechanisms. We have unique multi-omic biosample repositories for research from consented patients, and available for longitudinal follow-up, from our culturally-diverse local East...