Research Technician
Found in: beBee jobs GB - 3 weeks ago
We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
The Role
You will be responsible for differentiation of pluripotent stem cells to retinal organoids, enrichment of photoreceptors for subretinal transplantation by flow cytometry, organizing animal breeding and assisting the postdoctoral research assistants with immunofluorescence and FISH analyses of transplanted eyes. You will work as part of a team comprised of two postdoctoral research associates on this MRC funded project focusing on the assessment of engraftment of hESC-derived photoreceptors and their ability to restore vision in early and advanced stages of Retinitis Pigmentosa.
Retinitis pigmentosa (RP) is a common form of hereditary photoreceptor dystrophy associated with progressive rod degeneration of the mid-peripheral retina, leading to night blindness and loss of visual acuity. At later stages of the disease, cones degenerate as well, resulting in complete blindness at final disease stages. The supporting retinal pigment epithelium cell layer (RPE), which is essential for normal retina function is also altered at the end stages of disease due to photoreceptor death. Therefore, there is a pressing need to develop novel approaches either for photoreceptor replacement alone or in combination with RPE cells or for reactivation of dysfunctional surviving photoreceptor by gene therapy (if performed at early stages of the disease).
In our group, we develop artificial retinas (organoids) and RPE cells from human pluripotent stem cells (hPSCs). We isolate photoreceptors from these organoids and inject them in retinas with photoreceptor dystrophies, with the goal to achieve integration of these healthy photoreceptors into the host retina, eventually restoring visual function. We have successfully achieved these goals using a cone-enriched population of photoreceptor precursors in a mouse model of RP, resulting in partial restoration of visual function assessed by behavioural and electrophysiological testing. However, given the prevalence of rod degeneration in RP, our hypothesis for this project is that transplantation of hPSCs-derived rods at early stages may lead to improved rod integration and function, while also protecting cones from degenerating at later stages. On the other hand, we suggest that a combination of rod, cone and RPE transplantation may achieve optimal results at more advanced stages of retinal degeneration.
You will work under the direction of all three investigators on a full-time, fixed-term basis from 1 June 2024 for 18 months.
Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.
For informal enquiries contact: Professor Majlinda Lako.
Find out more about the Faculty of Medical Sciences here:
Find out more about our Research Institutes here:
£25,742 to £26,444 with progression to £27,979 per annum.
-
HTRC Metrology Technician
7 days ago
Newcastle upon Tyne, United Kingdom MTC OPERATIONS LIMITED Full timeThere is an exciting opportunity for a Technician to support Operations within the High Temperature Research Centre Metrology Department based in Coventry.This role will involve supporting the manufacturing process from initial request through to delivery of components, including but not limited to: Maintaining a safe working environment for one's self and...
-
Research Assistant/associate
2 days ago
Newcastle upon Tyne, United Kingdom Newcastle University Full time**Salary**: Starting **Research Assistant**: £31,396 - £32,982 per annum **Research Associate**: £33,966 - £36,024 per annum, with progression to £44,263 per annum Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health...
-
Newcastle upon Tyne, United Kingdom Newcastle University Full time**Salary**: £33,966 - £44,263 per annum Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. **Closing Date**: 11 February 2024 The role This is an exciting opportunity to become...
-
Newcastle upon Tyne, United Kingdom Quantumdx Group Full timeThe role of the Engineering Technician is to support the development of engineering solutions for our Q-POC platform, and the development of engineering solutions for research and commercial development across our platforms. This role will last for six months. Performing a combination, but not necessarily all, of the following duties: The Engineering...
-
Polymer / Material Science Graduate
Found in: beBee S GB - 3 weeks ago
Newcastle upon Tyne, United Kingdom Rise Technical Recruitment Ltd Full timePolymer / Material Science GraduateNewcastle (Commutable from: Cramlington, Blyth, North Shields, Morpeth, Ashington, Sunderland, Washington, Prudhoe, Gateshead)£30,000 - £40,000 + Training + Progression + BenefitsDo you have a Polymer / Material Science degree or qualification looking to work for a global leading business offering full training...
-
Field Operations Supervisor
2 weeks ago
Ouseburn, Newcastle upon Tyne, United Kingdom JLB Recruitment Ltd Full timeThe Role Includes * Undertaking structured review of skills and performance across all technicians disciplines. * Continual review and audit of technicians working practices, ethics, customer skills and communication. * Preparation of individual training plans based on development needs. * Developing a robust programme of Toolbox Talks & Lessons...
-
Field Operations Supervisor
Found in: Whatjobs ES C2 - 1 week ago
Ouseburn, Newcastle upon Tyne, United Kingdom JLB Recruitment Ltd Full timeThe Role Includes * Undertaking structured review of skills and performance across all technicians disciplines. * Continual review and audit of technicians working practices, ethics, customer skills and communication. * Preparation of individual training plans based on development needs. * Developing a robust programme of Toolbox Talks & Lessons Learned. *...
-
Newcastle upon Tyne, United Kingdom Department for Work and Pensions Full time**Details**: **Reference number**: - 260130**Salary**: - £71,044 - £77,801**Job grade**: - Grade 6- **Contract type**: - Permanent**Business area**: - DWP - Finance Group**Type of role**: - Finance**Working pattern**: - Flexible working, Full-time, Job share, Part-time**Number of jobs available**: - 3Contents Location About the...
-
PhD Studentship: Implications of Extreme Temperatures on Physiological and Cognitive Functioning in Offshore Wind Technicians
Found in: beBee S GB - 4 days ago
Kingston upon Hull, United Kingdom University of Hull Full timeWork in offshore settings requires workers to engage in a variety of potentially risky, physically, and mentally demanding tasks. In 2019, 865 offshore accidents were reported, and similar numbers of incidents (including near hit/miss, amongst others) were reported in 2022. Human error is reported to be one of the most common causes of accidents on OSW...
-
Maintenance Technician
3 weeks ago
Sunderland, Tyne and Wear, United Kingdom NRL Recruitment Full timeDepartment: Maintenance Location: Sunderland Job Title: Maintenance Technician Salary: £49,228 rising to £60,232 including shift allowance. Contract Type: Permanent This is an exciting opportunity to be part of one of the North East’s highest profile manufacturing plants as we are expanding our operations at our battery manufacturing plant in Sunderland....
-
Reception/facilities Assistant
6 days ago
Newcastle upon Tyne, United Kingdom Newcastle University Full time**Salary**: £23,700 with progression to £25,138 per annum Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. **Closing Date**: 28 November 2023 The Role Do you enjoy working in...
-
Electrical Technician
7 days ago
Stratford-upon-Avon, United Kingdom CareerBliss Full timeAre you currently searching for an opportunity as an Auto Electrician?Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development...
-
Electrical Technician
7 days ago
Stratford-upon-Avon, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician?Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development...
-
Electrical Technician
1 week ago
Stratford-upon-Avon, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician?Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development...
-
Electrical Technician
6 days ago
Stratford-Upon-Avon, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician?Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development...
-
Electrical Technician
5 days ago
Stratford-upon-Avon, Warwickshire, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician? If your skills, experience, and qualifications match those in this job overview, do not delay your application. Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical...
-
Electrical Technician
Found in: Jooble UK C2 - 5 days ago
Stratford-upon-Avon, Warwickshire, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician? If your skills, experience, and qualifications match those in this job overview, do not delay your application. Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical...
-
Electrical Technician
1 week ago
Stratford-Upon-Avon, West Midlands, United Kingdom Expleo Group Full timeAre you currently searching for an opportunity as an Auto Electrician?If your skills, experience, and qualifications match those in this job overview, do not delay your application.Expleo are keen to keen to speak with experienced individuals looking for an exciting new challenge! The successful candidate will carry out automotive vehicle electrical support,...
-
Electrical Technician, Apprentice
Found in: Jooble UK C2 - 7 days ago
Stratford-upon-Avon, Warwickshire, United Kingdom Expleo Group Full timeThe successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development environment. Expleo can offer both contract (outside IR35 possible). To investigate and diagnose electrical issues, using diagnostic equipment. * Support Testing in static and...
-
Electrical Technician, Apprentice
6 days ago
Stratford-upon-Avon, Warwickshire, United Kingdom Expleo Group Full timeThe successful candidate will carry out automotive vehicle electrical support, including preparation, building, reworking and fault diagnostics within a Research and Development environment. Expleo can offer both contract (outside IR35 possible). To investigate and diagnose electrical issues, using diagnostic equipment. * Support Testing in static and...