PhD Studentship: Hot spots and pressure points: Developing AI to identify normal and pathological periprosthetic osteoblastic activity for total knee arthroplasty on SPECT/CT

4 weeks ago


Exeter, Devon, United Kingdom University of Exeter Full time

Project description:

Single photon emission computed tomography (SPECT-CT) imaging combines functional and anatomical data, enhancing diagnostics but remains underutilized and provides non-specific diagnosis. SPECT-CT's clinical value in assessing painful knee replacements (TKRs) includes accurate 3D analysis of component positioning and tracer uptake. However, there is limited differentiation between expected and pathological radiopharmaceutical uptake equivocal results in many cases.

The aim of this PhD studentship is to develop an advanced artificial intelligence algorithm incorporating finite element analysis and computer vision technology to improve prediction of areas where increased radiopharmaceutical uptake is expected versus pathological uptake.

The team has a dataset of 45 SPECT/CT scans with TKRs and known patient outcomes. These will be segmented for anatomical structures on CT and augmented with SPECT scans to provide anatomical and pathological ground truth images. Current AI models of the knee anatomical structures derived from MRI, developed by Prof Ye, will be adapted using transfer learning or domain adaptation methods and mapped to FEA predictions of periprosthetic stress and strain areas.

Training in machine learning, computer vision and finite element analysis, image interpretation of SPECT/CT and pathophysiology will be provided by expert supervisors in these fields.

The Department of Health and Care Professions has strong links and a long working relationship with the orthopaedic team locally. Images to support this study are already held by the group and software to facilitate the work is available.



  • Exeter, Devon, United Kingdom University of Exeter Full time

    The UKRI AI Centre for Doctoral Training in Environmental IntelligenceData Science & AI for Sustainable Futures at University of Exeter in partnership with the Alan Turing Institute is offering fully funded PhD studentships.These prestigious studentships would be based jointly at University of Exeter (Streatham campus) and at the headquarters of the Alan...

  • PhD Studentship

    4 weeks ago


    Exeter, Devon, United Kingdom University of Exeter Full time

    The increasing reliance on electrical energy in contemporary society has made the stability and reliability of power systems a paramount concern. Rapid population growth, the inefficiency of traditional power plants, the proliferation of electrical devices, and the high cost of establishing new power plants have led to power systems operating near their...

  • Knee Surgery Fellow

    4 weeks ago


    Exeter, Devon, United Kingdom Royal Devon and Exeter NHS Foundation Trust Full time

    Position OverviewThe Royal Devon and Exeter NHS Foundation Trust is renowned for its commitment to orthopaedic excellence and innovation. Our Orthopaedic Centre is a dynamic environment, boasting a wealth of subspecialty knowledge.The Exeter Knee Reconstruction Unit (EKRU) addresses a wide array of knee-related issues, including sports injuries, various...


  • Exeter, Devon, United Kingdom Royal Devon and Exeter NHS Foundation Trust Full time

    Position OverviewThe Royal Devon and Exeter NHS Foundation Trust is renowned for its commitment to orthopaedic excellence and innovation. Our Orthopaedic Centre is a vibrant hub of expertise, particularly in knee-related conditions.The Exeter Knee Reconstruction Unit (EKRU) specializes in addressing a wide array of knee issues, including sports injuries,...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Project description:There is well-established evidence from primary care that continuity of care with a single healthcare professional, such as a GP, can lead to improved care and clinical outcomes. However, this key concept has diminished as multiple long-term condition pathways and multi-disciplinary teams have superseded the idea of a primary HCP...


  • Exeter, Devon, United Kingdom Royal Devon and Exeter NHS Foundation Trust Full time

    Position Overview The Royal Devon and Exeter NHS Foundation Trust is renowned for its commitment to orthopaedic excellence and innovation. The Exeter Knee Reconstruction Unit (EKRU) is a leading facility that addresses a wide range of knee-related issues, including sports injuries, osteoarthritis, rheumatoid arthritis, and complex surgical cases. EKRU...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Project description:Abdominal wall function (AWF) represents the interplay of muscles, nerves, fascia and subcutaneous tissues. AWF is important, complex and poorly understood, with wide-reaching implications in the abdomen and almost all areas of physical function. It is commonly affected by hernias and surgery, which can significantly disrupt physical...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    About the AwardNIHR Global Health Research programmes aim to improve health outcomes for the most vulnerable people in low and middle-income countries (LMICs). This 4-year collaborative project brings together researchers across five institutions in the UK and sub-Saharan Africa to improve outcomes for people with type 2 diabetes. It aims to understand how...

  • Hip and Knee Fellow

    2 months ago


    Exeter, Devon, United Kingdom Royal Devon University Healthcare NHS Foundation Trust Full time

    Applications are invited for the post of Senior Fellow in Hip and Knee Surgery (Clinical and Research) at the Princess Elizabeth Orthopaedic Centre, Royal Devon & Exeter Hospital, Exeter UK. This is a fixed term post for 12 months, commencing in the 1st week of August 2025 until the 1st week of August 2026. The post will involve 6 months as a Fellow with the...

  • Knee Fellow

    1 month ago


    Exeter, Devon, United Kingdom Royal Devon University Healthcare NHS Foundation Trust Full time

    The Princess Elizabeth Orthopaedic Centre at the RD& E has a long history of orthopaedic innovation and excellence. It is a thriving department with significant subspecialty expertise. The Exeter Knee Reconstruction Unit (EKRU) manages all knee problems including sports injuries, early and advanced osteoarthritis, rheumatoid arthritis, revision surgery and...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    About the AwardNIHR Global Health Research programmes aim to improve health outcomes for the most vulnerable people in low and middle-income countries (LMICs). This 4-year collaborative project bring together researchers five institutions in the UK and sub-Saharan Africa (SSA)to improve outcomes for people with type 2 diabetes in SSA . It aims to understand...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Location: Department of Computer Science, Streatham Campus, Exeter The University of Exeter's Department of Computer Science is inviting applications for a PhD studentship fully-funded by the faculty of Environment, Science and Economy to commence on 23 September 2024 or as soon as possible thereafter. For eligible students the studentship will cover Home or...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    About the Award:NIHR Global Health Research programmes aim to improve health outcomes for the most vulnerable people in low and middle-income countries (LMICs). This 4-year collaborative project brings together researchers from five institutions in the UK and sub-Saharan Africa (SSA) to improve outcomes for people with type 2 diabetes. It aims to understand...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Project description:NHS electronic health records from GP practices have provided a world-leading resource for research for over 20 years. UK hospitals are now also adopting fully electronic patient records, collecting high-fidelity data on patient journeys in hospital and as outpatients for the first time.This data science focused PhD offers an exciting...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Project description:The MRC Centre for Medical Mycology (CMM) at the University of Exeter conducts world-leading research of growing importance, globally and locally. CMM provides an exciting programme of public engagement activities. This PhD opportunity will strengthen patient and public involvement (PPI) in this field.PPI means that members of the public...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Project description:Complex interventions are characterised as having several potentially interacting components. There are unique methodological considerations in designing and analysing randomised trials to evaluate complex interventions. These include adherence, potential for the intervention (and/or control) to be delivered in a group-setting and other...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    Location:Department of Computer Science, Streatham Campus, Exeter,The Department of Computer Science at the University of Exeter is currently accepting applications for a fully funded PhD studentship, with a negotiable enrolment date open until January 2026 or earlier. For eligible students the studentship will cover Home or International tuition fees plus...


  • Exeter, Devon, United Kingdom Nuffield Health Full time

    About Nuffield HealthNuffield Health is a leading healthcare provider with a strong commitment to delivering high-quality patient care. Our team of dedicated professionals is passionate about making a positive impact on people's lives.Job SummaryWe are seeking a highly skilled Medical Laboratory Assistant to join our Pathology team at our Exeter Hospital. As...


  • Exeter, Devon, United Kingdom University of Exeter Full time

    This new full-time post is available from 2 December 2024 on a permanent basis.This role offers the opportunity for hybrid working – some time on campus and some from home.We welcome applications from candidates interested in working part-time hours or job-sharing arrangements.The roleA position has become available for a Diagnostic Radiographer to join...


  • Exeter, Devon, United Kingdom Nuffield Health Full time

    Job SummaryWe are seeking a highly motivated and detail-oriented Medical Laboratory Assistant to join our Pathology team at Nuffield Health Exeter Hospital. As a Medical Laboratory Assistant, you will provide high-quality support to our team, ensuring the smooth operation of our laboratory services.Key ResponsibilitiesProvide administrative support to the...