Postdoctoral Research Assistant
4 weeks ago
Chemical Biology - Discovery Probes for Ubiquitin-like E3 Ligases
Modification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the development of activity-based probes (ABPs) for the related ubiquitin system, which has led to several field-changing discoveries (Pao et al., Nat Chem Bio 2016; Pao et al., Nature 2018; Mathur et al., Cell Chem Biol. 2020; Mabbitt et al. Nat Chem Biol This project will build upon this expertise and expand its approach to Ubl systems. Ubl E3 ABPs will be constructed using the lab's modular chemical protein synthesis methods. These powerful tools will then be deployed in combination with proteomics to discover entirely novel E3 ligases. Insights into these understudied posttranslational modifications will enrich our understanding of their function and could enable the development of new therapeutic targets.
The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide an excellent opportunity for career development with mentoring support to reach career aspirations. The successful applicants will join an international team in an exciting and interactive environment, equipped to the very highest standards, and with generous consumable support.
Your priorities will include:
• Chemical protein synthesis of protein-based probe molecules for Ubl E3s
• Assays using purified protein and cell extracts
• Preparation of data for manuscript preparation
• Liaise with other lab members and collaborators
• Maintenance of meticulous lab records
Who we're looking for:
Enthusiastic candidates should ideally have recently carried out a PhD working in structural biology or biochemistry.
• Enthusiasm for technology development working at the chemistry-biology interface
• Experience with chemical biology techniques
• Biochemical experience
This contract is for a fixed term period of 3 years.
MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU):
The MRC PPU is one of the world's most renowned centres for research on protein phosphorylation and ubiquitylation ). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation and ubiquitylation, to generate reagents and improve technologies. A key remit of the MRC PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.
School of Life Sciences (SLS):
The MRC PPU is based within the School of Life Sciences at the University of Dundee, a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
-
Postdoctoral Research Assistant
1 week ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are looking for an exceptional individual to join the Sapkota Lab as a Postdoctoral Researcher to work on an innovative project aimed at targeting Wnt signalling in cancer. Hyperactive Wnt signalling is associated with colorectal and other cancers. We have discovered that the poorly charcaterised proteins FAM83F and FAM83G activate Wnt signalling through...
-
Postdoctoral Research Assistant
5 days ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are looking for an exceptional individual to join the Sapkota Lab as a Postdoctoral Researcher to work on an innovative project aimed at targeting Wnt signalling in cancer. Hyperactive Wnt signalling is associated with colorectal and other cancers. We have discovered that the poorly charcaterised proteins FAM83F and FAM83G activate Wnt signalling through...
-
Postdoctoral Research Assistant
2 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting a postdoctoral researcher to take up a position within the Swamy group in the University of Dundee, to study potential new therapeutic targets for treating Coeliac disease. This is a fixed-term appointment for 3 years starting August/September 2024.This is an exciting opportunity to be at the interface of clinical and basic research, and to...
-
Postdoctoral Research Assistant
6 days ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting a postdoctoral researcher to take up a position within the Swamy group in the University of Dundee, to study potential new therapeutic targets for treating Coeliac disease. This is a fixed-term appointment for 3 years starting August/September 2024.This is an exciting opportunity to be at the interface of clinical and basic research, and to...
-
Postdoctoral Researcher
2 months ago
Dundee, Dundee City, United Kingdom UNIVERSITY OF DUNDEE Full timeWe are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels...
-
Postdoctoral Researcher
6 days ago
Dundee, Dundee City, United Kingdom UNIVERSITY OF DUNDEE Full timeWe are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels...
-
Postdoctoral Research Assistant
4 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeRegulation of organelle-selective autophagy by ubiquitin E3 ligasesOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how...
-
Postdoctoral Research Assistant: Chemical Biology
2 months ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeModification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeModification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeModification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the...
-
Postdoctoral Research Assistant
2 months ago
Dundee, Dundee City, United Kingdom UNIVERSITY OF DUNDEE Full timeEnthusiastic candidates should ideally have recently carried out a PhD in biochemistry or a chemistry related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide an...
-
Postdoctoral Research Assistant
6 days ago
Dundee, Dundee City, United Kingdom UNIVERSITY OF DUNDEE Full timeEnthusiastic candidates should ideally have recently carried out a PhD in biochemistry or a chemistry related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide an...
-
Research Assistant
2 months ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are seeking a research assistant to join a research team involved in exploring the barriers and enablers to reducing unnecessary tests and treatments in dental primary care and sustainable oral health. This is an exciting opportunity for an enthusiastic researcher to build on existing work and conduct important and interesting research. It will also allow...
-
Research Assistant
2 months ago
Dundee, Dundee City, United Kingdom Abertay University Full timeFull time, Fixed term (for a period of 9 months)Abertay is a modern university with a global outlook, rooted in its local and national communities. We have made our mark with high quality, well-directed teaching and research, and a stimulating and enriching experience for our students.The Division of Psychology and Forensic Science in the School of Applied...
-
Research Assistant
2 months ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are seeking a research assistant, with qualitative skills and experience to join a research team involved in exploring and ultimately improve healthcare pathways for people with Osteogenesis Imperfecta (OI) (brittle bone disease). The project will have a focus on oral health. This is an exciting opportunity for an enthusiastic researcher to build on...
-
Postdoctoral Scientist
2 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are seeking a Scientist with research experience in organic synthesis and/or medicinal chemistry to join an industry academia, multi-disciplinary drug discovery team based in the new Centre for Targeted Protein Degradation (CeTPD) within Dundee's School of Life Sciences.The team is engaged in a major collaboration working on proteolysis-targeting...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has...