Postdoctoral Researcher
3 weeks ago
We are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels thousands of proteins to help shape the host immune response. However, the mechanisms underlying ISG15's contribution to immunity are largely unknown. This project focuses on the structural analysis of the writers of the ISG15 system. The postdoc will utilise several exciting new tools and reagents in the lab and expand on our recent progress in the area. A significant portion of the structural work will be performed using a brand-new Glacios Cryo Transmission Electron Microscope (Cryo-TEM) conveniently located in the School of Life Sciences. The successful applicant will gain hands-on training in Cryo-EM and work closely with the Cryo-EM facility. The project complements our efforts to understand the cellular roles of ISG15 modifications, and therefore, the postholder will have several opportunities for internal and external collaborations.
For further information about this position please contact Dr Kirby Swatek, . To find out more about Dr Kirby Swatek's lab, please visit
MRC Protein Phosphorylation and Ubiquitylation Unit
The Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU, ) is a top-tier research institute conveniently located in the School of Life Sciences at the University of Dundee, a leading university in life science research. Research Groups within the MRC PPU focus on understanding how protein phosphorylation and ubiquitylation control fundamental aspects of human health and how disruption of these cellular signals results in disease.
Additional Information:
For information on our values:
For information on life in Dundee:
To learn more about our research:
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With goo staff from over 60 countries worldwide the school provides a dynamic, multi-national, collegiate, and diverse environment with state-of-the-art laboratory, technology, and teaching facilities.
Your priorities will include:
• Structural analysis of the ISG15 system.
• Performing a wide array of multidisciplinary techniques.
• Advising and mentoring undergraduate and PhD students.
Presenting your research at lab meetings, workshops, and conferences.
• Writing manuscripts for publication.
Candidate requirements:
• PhD (or will complete your PhD studies within six months of the application deadline).
• A track record of academic success.
• Expertise in cryo-EM and/or X-ray crystallography is highly desirable.
• Experience in chemical biology, biochemistry, and purification of multiprotein complexes.
• A strong background in immune signalling and ubiquitin biology would be advantageous.
• The ability to teach a small multidisciplinary team of enthusiastic scientists.
• Excellent communication skills (both verbal and written).
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeApplications are invited for a Postdoctoral Research Assistant in the chemical biology lab of Professor Satpal Virdee. The project will develop innovative and urgently needed tools for studying the ubiquitin system. The ubiquitin system is a central regulator of the cell containing a wealth of undiscovered aspects and untapped therapeutic potential. Working...
-
Post-Doctoral Researcher
3 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting for a Grade 7 Post-Doctoral Researcher. This position is for 12 months.This is an exciting opportunity to join a new research team at the University of Dundee. David Koss and his team are focused on understanding the emerging role of DNA damage in the development and progression of neurodegenerative diseases. Specifically, this Postdoctoral...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeModification of proteins with ubiquitin-like proteins (Ubls) is a critical cellular process linked to pathogen resistance, cancer, and selective organelle degradation. Central to their conjugation to substrates are E3 ligase enzymes (E3s), yet for many Ubls the E3s are poorly understood or remain completely unknown. The Virdee lab has pioneered the...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels...
-
Postdoctoral Research Assistant
3 weeks ago
Dundee, Dundee City, United Kingdom UNIVERSITY OF DUNDEE Full timeEnthusiastic candidates should ideally have recently carried out a PhD in biochemistry or a chemistry related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide an...
-
Dundee, Dundee City, United Kingdom University of Dundee Full timeOrganelle-selective autophagy is emerging as a critical and highly coordinated cellular process, and its dysfunction is linked to cancer and neurological diseases. Crucially, organelle-selective autophagy requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has...
-
KOODAC Team Structural Biologist
2 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein- ligand and protein-protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is...
-
KOODAC Team Chemical Biologist
2 weeks ago
Dundee, Dundee City, United Kingdom University of Dundee Full timeWe are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with experience in compound screening and assay development to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic,...
-
Postdoctoral Researcher
3 weeks ago
Dundee, United Kingdom UNIVERSITY OF DUNDEE Full timeWe are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the immunoregulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and labels...
-
Post-Doctoral Researcher
3 weeks ago
Dundee, United Kingdom University of Dundee Full timeWe are recruiting for a Grade 7 Post-Doctoral Researcher. This position is for 12 months. This is an exciting opportunity to join a new research team at the University of Dundee. David Koss and his team are focused on understanding the emerging role of DNA damage in the development and progression of neurodegenerative diseases. Specifically, this...
