Senior Purification Scientist

1 month ago

Birmingham, Birmingham, United Kingdom Thermo Fisher Scientific Full time

Job Description

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life – To enable our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies.

Our work in specialty diagnostics – from providing diagnostic assays and instruments to clinical monitoring across disease stages – improves the diagnosis and management of blood cancers and immune system disorders. Your determination to put patients at the heart of every decision will improve health outcomes that people and communities depend on – now and in the future.

Location/Division Specific Information

The Binding Site Group, part of Thermo Fisher Scientific, is a global leader in specialty diagnostics, provides diagnostic assays and instruments to improve the diagnosis and management of blood cancers and immune system disorders. The Binding Site's Freelite offering is widely recommended for multiple myeloma diagnosis and monitoring across all stages of the disease by major clinical guideline publications. In addition, The Binding Site is an active and influential contributor to the broader scientific community. To find out more visit

Discover Impactful Work:

The post holder will be responsible for:

  • Assessing all technical and practical aspects of existing purification strategies and driving process improvements throughout the manufacturing teams to improve the quality and efficiency of product manufacture.
  • Critically analyse production equipment and drive improvements to equipment selection and process design to maximise manufacturing performance.
  • To participate in process development and transfer into manufacturing to maximise manufacturing performance.

A Day in the Life:

  • Lead the investigation, assessment and review of current purification manufacturing strategies.
  • Lead process data collection, analysis and interpretation.
  • Autonomy to Drive process improvements to yield and process performance in the current supply of intermediate protein reagents, focusing where required on alternative strategies and solutions to existing challenges
  • Lead the assessment of current equipment capabilities, driving improvements in technology to align with best-in-class industry standards.
  • Developing and leveraging expertise across the organization – instrumental in developing future manufacturing strategies to manufacture best in class biological reagents.
  • Assessment of new product introduction to ensure best industry practice is in use.
  • Assessment of non-conformance and CAPA to ensure best in class resolution of processing challenges.

Keys To Success:

Education

  • Degree in Biochemistry or equivalent scientific subject and/or higher degree in protein / immunoglobulin purification based research.

Experience

  • Candidate must have significant experience in protein purification techniques, with an expectation of at least 10 years' experience at large laboratory / pilot scale manufacturing.
  • Demonstrated ability to lead Projects either through experience or recognised project management training.

Knowledge, Skills, Abilities

  • Demonstrated knowledge of modern chromatography techniques, strategies and equipment
  • Demonstrated knowledge of protein biochemistry to drive process improvements.
  • Thorough understanding of concentration / diafiltration techniques and equipment
  • Experience of liaising with Key industry suppliers of purification technology
  • Detailed understanding of purification process and equipment validation
  • Project management

Physical Requirements / Work Environment

  • The role will include a mix of office based work and some physical laboratory and pilot scale manufacturing activity

Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory at Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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