Senior Scientist, Discovery Genomics

Are you a passionate and skilled genomics scientist ready to make an impact in the world of drug discovery? Here's your chance to be at the heart of groundbreaking research and pioneering discoveries that shape the future of medicine in the Discovery Genomics group within the Target Discovery department at GSK.

Why Join Us:

• Cutting-Edge Research: You will be instrumental in shaping experiments and providing critical datasets for in-house CRISPR, chemical and large molecule screening. Your contributions will directly drive target discovery and validation at scale, pushing the boundaries of what's possible in genomics.
• Collaborative Environment: You'll have the opportunity to support diverse projects across the pipeline, working hand-in-hand with colleagues to generate evidence that addresses key questions for GSK's assets and disease focus areas. Our team spans three GSK sites in Stevenage (UK), Heidelberg (Germany) and Philadelphia (USA), with opportunities to work on multi-Omics projects that span multiple locations.
• Impactful Work: Your efforts will directly impact patient outcomes. By leveraging your expertise in genomics assays, you'll play a pivotal role in advancing our understanding of diseases and developing novel therapeutic solutions.

What You'll Do:

• Innovative Research: Implement a wide range of genomics assays, from RNA-seq and scRNA-seq techniques to epigenetics assays and next-generation sequencing. Your role will involve not only utilizing existing techniques but also pioneering new approaches to enhance our discovery methodologies.
• Collaborative Partnerships: Navigate a highly matrixed organization, collaborating closely with key stakeholders in computational biology, AIML, and biology research units. Together, we'll work towards common goals and make impactful decisions that benefit patients worldwide.
• Continuous Learning: Stay at the forefront of the field by scoping out new techniques and technologies that could revolutionize our discovery approaches. Whether it's experimental, in silico, or automation technologies, you'll have scope to explore and implement the latest advancements in genomics research which benefit our work.

What You Bring:

• Passion and Drive: A relentless passion for genomics research and a drive to make a meaningful difference in the lives of patients.
• Expertise: A solid foundation in genomics assays, coupled with hands-on experience in techniques such as RNA-seq, single-cell sequencing, and epigenetics assays.
• Collaborative Spirit: An ability to thrive in a collaborative environment, working seamlessly with colleagues from diverse backgrounds to achieve common objectives.
• Innovation: A creative mindset and a knack for exploring new techniques and technologies to push the boundaries of discovery.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

Key Responsibilities include, but are not limited to:

• Planning and executing data generating phases of screens where you will be designing and executing single cell and bulk transcriptomics workflows which are key parts of our discovery screening projects.
• Maintain and improve critical lab workflows and equipment in collaboration with automation experts and vendors.
• As part of the Discovery Genomics group, other responsibilities will include assisting with sequencing workflows, and data QC and analysis where appropriate.
• You will demonstrate the ability to work effectively in multidisciplinary teams and will display excellent interpersonal and communication skills, interacting with scientists and external collaborators at all levels.
• You will be expected to maintain knowledge of current scientific literature relevant to the role.
• A proactive attitude, excellent organisational skills and good record keeping are essential. You will be expected to present your results/data at both internal and external meetings.

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

• PhD or equivalent laboratory experience in molecular and cellular biology with significant experience in genomics workflows.
• Demonstrated experience in designing experiments using bulk RNA-seq and single cell RNA-seq and related technologies.
• Sound knowledge of molecular biology techniques including: qRT-PCR, NGS library preparation and QC.
• Demonstrated ability to design experiments, solve problems independently, troubleshoot protocols and implement novel protocols.
• Proven ability to work independently and as part of a multidisciplinary team.
• Strong organisational and communication skills and a demonstrated ability to liaise with scientists at all levels of seniority.

Preferred Qualifications

If you have the following characteristics, it would be a plus:

• Experience in applying computational analysis methodologies for genomics data, including data QC, pre-processing and primary analysis, in particular for RNA-seq or single cell RNA-seq.
• Understanding of focused and/or genome-wide pooled CRISPR screens.
• Understanding of the drug discovery process and how genomics can be used to support target discovery and assets in later stages of the pipeline.
• Working knowledge of immunology or experience with primary human cell based projects.
• Demonstrated experience in working on projects using complex in vitro models, such as primary (immune) cells, iPSCs or organoids/spheroids.

Closing Date for Applications – 24th May 2024 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.

Find out more:

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