R&D Scientist
4 days ago
An exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.
Responsibilities:
The purpose of this role is to develop mammalian plasmid constructs for optimal expression of antibody therapeutics to be used in mammalian bioprocesses. As a Scientist you will be part of an innovative multidisciplinary team that will develop the next generation of mammalian expression systems & cells lines to enable highly productive pharmaceutical bioprocesses and, ultimately, more cost effective Immunotherapeutics.
• Design and screen mammalian gene expression plasmids for high and stable expression of therapeutic antibodies including bi-/tri-specific antibodies
• Design and optimise CRISPR knock-out and ORF libraries to be used in high throughput functional genomics pipelines
• Design, plan, and execute complex R&D experiments ensuring that deliverables are successfully met within timelines
• Document research findings clearly in a lab book
• Communicate regularly in group meetings and prepare and deliver presentations to project team and internal stakeholders
• Along with team members, provide routine laboratory maintenance, including participating in equipment upkeep, cleaning rotas and laboratory consumables stock management
• Shared responsibility for out-of-hours cell culture maintenance.
• Ensure that laboratory health, safety and quality procedures are followed
• Select, follow, and adapt experimental protocols and generate laboratory SOPs
• Support the preparation of laboratory risk assessments and maintenance of health and safety protocols
• Maintain the confidentiality of the project and protocols
• Keep abreast of current technologies and relevant scientific literature to help identify opportunity for improvements and reduction of costs
Experience Required
Essential Experience:
• BSc/MSc in Biochemistry, Molecular Biology or related field
• BSc/MSc with 3+ years of industry experience or PhD with 1-2 years’ experience
• Extensive experience of designing, preparing and screening mammalian gene expression plasmids within the context of mammalian cell line development
• Experience of designing CRISPR knock-out and ORF libraries for high-throughput functional genomics screens
• Experience of working safely with 3rd generation lentiviral plasmid systems within a CAT2.0 environment
• Experience of designing mammalian gene expression constructs for Immunotherapeutics molecules eg. antibodies
• Experience of working with bioprocess relevant cell lines eg. CHO or HEK293
• Familiarity of mammalian cell line development including generation of GM/GE cell lines, single cell cloning and clonal screening
• Experience of mammalian cell culture and related techniques including passaging, banking, transfection, nucleofection & genotyping
• Skilled in molecular biology techniques including PCR, qRT-PCR, Western Blot, ELISA, plasmid preparation, plasmid cloning, site directed mutagenesis & FACS
• Experience of working with SnapGene or related software
• Skilled in experimental design and troubleshooting
• Ability to work independently and as part of team
• Good numeracy, computer and communication skills
• Experience of writing SOPs and risk assessment
Desirable Experience:
• Application of Design of Experiments (DOE) to rationalise experiment design
• Familiarity of working with large datasets including transcriptomic / proteomic datasets
• Experience with automation and high-throughput technologies applied to mammalian cell line generation eg. Beacon, 96 deep well plate model systems & Ambr15
£40k - £55k + Benefits
-
R&D Scientist
2 days ago
Oxford, United Kingdom Cranleigh Stem, Sustainability & Sheq Recruitment Full timeAn exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up.With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities: The purpose of this role is to develop mammalian plasmid...
-
R&D Scientist
3 days ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeJob Description An exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development. Responsibilities: The purpose of this role is to develop...
-
R&D Scientist
24 hours ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeAn exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities:The purpose of this role is to develop mammalian plasmid...
-
R&D Scientist
4 days ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeAn exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities:The purpose of this role is to develop mammalian plasmid...
-
R&D Scientist
5 days ago
Oxford, UK, Oxfordshire, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeAn exciting opportunity is available for an R&D Scientist with expertise in Vector Development to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.Responsibilities:The purpose of this role is to develop mammalian plasmid...
-
Senior NGS Research Scientist
1 month ago
Oxford, Oxfordshire, United Kingdom Taylorollinson Full timeJob Title: Senior NGS Research ScientistJob Summary:We are seeking an experienced NGS Research Scientist to join our team at Taylorollinson. As a key member of our R&D team, you will be responsible for leading technical projects and overseeing the development of NGS assays.Key Responsibilities:Act as technical lead on R&D projects for the improvement and...
-
Senior NGS Research Scientist
1 month ago
Oxford, United Kingdom CV-Library Full timeSenior NGS Research Scientist Location – Oxfordshire Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their...
-
Senior Scientist
3 weeks ago
Oxford, United Kingdom CV-Library Full timeCK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...
-
Senior Scientist
2 hours ago
Oxford, United Kingdom CK Group- Science, Clinical and Technical Full timeCK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...
-
Data Scientist
4 weeks ago
Oxford, Oxfordshire, United Kingdom Cranleigh STEM Full timeCranleigh STEM is seeking an exceptional Data Scientist to collaborate closely with our R&D team, leveraging advanced computational and machine learning/deep learning approaches to support our cell line development programs.You'll be part of a diverse team of biologists, automation scientists, and chemical engineers, meeting project deadlines and delivering...
-
Senior Scientist
3 weeks ago
Oxford, United Kingdom CK Group- Science, Clinical and Technical Full timeCK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...
-
Scientist - Virology
2 hours ago
Oxford, United Kingdom Ck Group Full timeJob Title A Scientist Position in Virology and Molecular Biology The Role We are seeking an experienced scientist to contribute to strategic R&D projects, designing and executing studies to support oncolytic virus candidate pipeline development under Good Clinical Laboratory Practice (GCLP).Your Responsibilities Presenting research findings and data at...
-
Data Scientist
4 weeks ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeOur start-up client is expanding their Data Science team and are excited to welcome a Data Scientist who will collaborate closely with their R&D team. In this role, you’ll leverage advanced computational and machine learning/deep learning approaches to support their cell line development programs. Your work will drive innovation in mammalian cell line...
-
Data Scientist
4 weeks ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeOur start-up client is expanding their Data Science team and are excited to welcome a Data Scientist who will collaborate closely with their R&D team. In this role, you’ll leverage advanced computational and machine learning/deep learning approaches to support their cell line development programs. Your work will drive innovation in mammalian cell line...
-
Data Scientist
3 weeks ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeOur start-up client is expanding their Data Science team and are excited to welcome a Data Scientist who will collaborate closely with their R&D team. In this role, you’ll leverage advanced computational and machine learning/deep learning approaches to support their cell line development programs. Your work will drive innovation in mammalian cell line...
-
Data Scientist
4 weeks ago
Oxford, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeOur start-up client is expanding their Data Science team and are excited to welcome a Data Scientist who will collaborate closely with their R&D team. In this role, you’ll leverage advanced computational and machine learning/deep learning approaches to support their cell line development programs. Your work will drive innovation in mammalian cell line...
-
Senior Scientist
2 weeks ago
Oxford, United Kingdom CK Group Full timeCK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...
-
Senior Scientist
3 weeks ago
Oxford, United Kingdom CK Group Full timeCK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...
-
Senior Research Scientist
2 weeks ago
Oxford, Oxfordshire, United Kingdom CK Group Full timeJob OverviewCK Group is a leading biotechnology company based in Oxford, seeking an experienced Senior Scientist with a strong background in cancer biology to join their research team on a permanent basis.The Role:This position involves contributing to strategic R&D goals by designing, managing, and performing studies to support candidate development and...
-
PhD Research Scientist
3 weeks ago
Oxford, United Kingdom CK Group- Science, Clinical and Technical Full timeCK Group are recruiting for an experienced Scientist with technical expertise in virology and molecular biology, to join a growing biotechnology company, on a permanent basis to be based in Oxford. A great opportunity for a proactive, highly organised scientist with a commitment to research on anti-cancer therapies to take responsibility in a fast-paced...