Senior Research Scientist I

2 weeks ago

London, Greater London, United Kingdom Sygnature Discovery Limited Full time

Sygnature Discovery is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City.

Its staff of over 1,000, which includes 900 scientists, partners with global pharma , biotech and NFP organisations.
Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, fibrotic diseases and more.

Whether you've recently completed your PhD or have several years' experience under your belt, we'd love to hear from you.

Work on integrated drug discovery projects with some of the most high profile global biotech and pharma companies.
Chance to train and develop expertise using the latest AI/ML software.
Learn about and apply new and emerging free energy methods on projects datasets.
Develop drug discovery knowledge by formal training and project experience.

Be part of an expanding group at the forefront of applying new software and techniques to drug discovery projects.

You will have a PhD in computational chemistry or a related discipline.
You will have worked on structure-based design projects and be familiar with this approach to optimise ligand binding.
Experience of working on fragment-based design projects would also be an advantage.
Familiarity with SAR analysis of project data sets and calculation of ADME/Tox relevant properties.
You will have carried our virtual screening, either using protein x-ray structures or a ligand-based method.

Protein sequence analysis and homology modelling - experience of multiple sequence alignment and homology modelling across numerous protein classes, including GPCRs, would be an advantage.

Familiarity with data pipelining tools and an ability to script in python.
A drug discovery background gained within a pharmaceutical company or a CRO is desirable.
Here at Sygnature Discovery, we take pride in offering an excellent training and benefits package. 25 days annual leave (rising with service) plus bank holidays, and buy/sell scheme

  • Private Medical Insurance
  • Life Insurance
  • Employee Assistance Programme and mental health first aiders
  • Enhanced Family Friendly Policies
  • Sygnature Group Pension Scheme
  • A host of flexible benefits to support your wellbeing and lifestyle
From pioneering research to ground-breaking discoveries, we set the standard for scientific innovation. Across continents and disciplines, we unite to solve complex challenges, driven by a shared passion for improving lives worldwide.

That's why we have fostered a culture of collaboration and support, providing pathways for both professional and personal development.

This includes a diverse range of bespoke training and development designed to accelerate both your personal and career growth.
We are committed to fostering diversity and inclusion throughout our organisation.

We encourage applications from individuals of all backgrounds, ethnicity, gender identity, sexual orientation, disability, neurodiversity, age, family or parental status, beliefs, nationalities and religions.

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