Research Assistant/associate in Imaging Neuroscience
2 weeks ago
Salary:
Research Assistant:
£31,396 to £32,982 per annum
Research Associate £33,966 to £36,024 per annum
Newcastle University is a great place to work, with excellent benefits.
We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
Closing Date: 16 February 2024
The Role
We are looking to recruit a motivated researcher interested in an exciting multi-disciplinary translational neuroscience project funded by the Motor Neuron Disease Scotland charity with the aim of developing a rapid, sensitive and entirely non-invasive diagnostic test for this disease.
You will join a multi-disciplinary team of neuroscientists, MR physicists, neuroradiologists and computer scientists and will be primarily responsible for developing magnetic resonance imaging protocols to image skeletal motor unit activity first in healthy controls, and then in patients with motor neuron disease (MND).
Motor neurone disease (MND) - also known as Amyotrophic Lateral Sclerosis (ALS) - is a rapidly disabling and fatal neurodegenerative disease affecting 1 in 10,000.
Underlying this devastating condition is the progressive loss of skeletal motor units (a single motor axon and all of the muscle fibres that this innervates).
Current diagnostic tests are invasive, relatively insensitive, and available only in larger centres, meaning that patients still typically wait up to 12 months to get a diagnosis.
This matters because it delays access to life-prolonging treatments and prevents early recruitment of patients to clinical trials of new therapies.
Our group has recently patented a novel method of imaging human motor units using a variation of diffusion-weighted MRI.We call this motor unit MRI or MUMRI, and are the only group in the world currently developing this technology.
We have used MUMRI to study the earliest signs of motor unit dysfunction in MND patients and have already translated this to our local NHS hospital's scanners.
The aim of this project is to build on this work to develop and test methods of detecting both early and late disease stages in the same scan session, thereby creating a rapid, sensitive and entirely non-invasive diagnostic test for MND.
You will obtain the necessary regulatory approvals for these studies, arrange for both healthy volunteers and patients to attend scanning sessions, perform the experiments and analyse the imaging data.
Finally, you will be responsible for producing publication-quality figures illustrating our findings, and for writing the first draft of manuscripts reporting the results.
This post is fixed term for a period until 30/11/2026 in the first instance.Find out more about our Research Institutes here:
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles.
These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Key AccountabilitiesDeveloping an MRI scan protocol to time lock diffusion-weighted image acquisition to electrical and auditory stimulation in healthy volunteers.
Obtaining regulatory approvals for studies in healthy volunteers and patients with motor neuron disease.
Organising healthy volunteer and patient visits to the Centre for In Vivo Imaging.
Analysis of neurophysiological and imaging data using MATLAB environment.
Preparation and collation of scanner protocols, data and regulatory documentation.
The Person (Essential)
Knowledge, Skills and Experience
Desirable
Good knowledge of the scientific literature on Motor Neuron Disease
Experience of the MATLAB platform, and writing scripts to analyse neurophysiological and imaging data
Attributes and Behaviour
Ability to work within a varied team to deliver requirements of project
Qualifications:
A PhD in relevant area for Research Associate
Close to submission/completion of PhD for Research Assistant
Newcastle University is a global University where everyone is treated with dignity and respect.
As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.
At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality.
We also hold a Race Equality Charter Bronze award in recognition of our work towards tackling race inequality in higher education REC.
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