Research Assistant/associate
2 weeks ago
Salary:
Research Assistant:
£31,396 to £32,982 per annum
Research Associate:
£33,966 to £44,263 per annum
Newcastle University is a great place to work, with excellent benefits.
We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
Closing Date: 15 April 2024
The Role
We are looking for a researcher with clinical interests to work on projects aimed at diagnosing neuromuscular disease patients.
The John Walton Muscular Dystrophy Research Centre (JWMDRC) has a strong interest in research, diagnosis and management of neuromuscular genetic disease.
We have secured funding to continue cutting edge genetic research utilising next generation sequencing technology to diagnosis patients with genetic neuromuscular diseases from a large international collaborative project in Latin-American countries (Latin-SEQ).
As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles.
These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Please note that if you are successful to this role, you will require medical clearance before you can commence in the roleThis post is tenable for 24 months.
Key Accountabilities
Liaise with centres collaborating in the Latin-SEQ project for the recruitment of patients and provide SOPs for collection of standardised clinical data in the PhenoTips database.
Confirm that patients meet the inclusion criteria of the project, and that deep phenotypic information and appropriate consent is providedPerform DNA extraction from blood (both fresh and dried spots), saliva, skin and/or muscle biopsies. Liaise with the sequencing provider (CNAG, Barcelona) for the shipment of DNA for exome sequencing
Analyse and clinically interpret results of next generation sequencing data generated through the Latin-SEQ project. Upkeep of the Latin-SEQ database, including patients enrolled, recruited, analysed and in waiting list, genetic and phenotypic data, results, communications with centres, MRI and muscle biopsy images
Preparation and collation of results for discussion and interpretation within multidisciplinary teams and referring centres in weekly meetings. Preparation of genetic reports. These meetings will be in Spanish or Portuguese
Carry out experimental procedures and developing new research methods to fit the research ongoing in the team. Undertake reading and literature review in appropriate fields of molecular biology and genetic medicine and make desirable modifications to methods and/or pipelines from relevant literature review
Provide training, advice and practical support to junior members and project students in genetic data analysis and clinical interpretation of genetic results
The Person
Knowledge, Skills and Experience
Experience working with large genetic datasets
Experience in medical genetics research
Demonstrable deep knowledge on the clinical, genetic, muscle MRI and muscle biopsy features of neuromuscular diseases
Fluent communication in Spanish (written and spoken)
Desirable
Experience in the analysis and interpretation of NGS data for rare diseases
Knowledge of Portuguese
Experience with handling skeletal muscle samples and histological techniques
Experience in the rare disease field, preferably neuromuscular conditions
Publication in major journals and presentation of data at conferences
Attributes and Behaviour
Advanced skills directly related to the research projects
High level of analytical and problem-solving capability and attention to detail
Good time management and ability to prioritise to meet deadlines
Qualifications:
Newcastle University is a global University where everyone is treated with dignity and respect.
As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.
At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality.
We also hold a Race Equality Charter Bronze award in recognition of our work towards tackling race inequality in higher education REC.
We are a Disability Confident employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme.
In addition, we are a member of the Euraxess initiative supporting researchers in Europe.Requisition ID: 26917
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