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    {"title": "Postdoctoral Research Assistant in Bioengineering", "content": "Research OpportunityWe are seeking a highly skilled Postdoctoral Research Assistant to join our team at the Institute of Biomedical Engineering of the Department of Engineering Science at the University of Oxford. The successful candidate will be part of the Oxford Centre for Tissue...


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Postdoctoral Research Assistant

3 months ago


Oxford, Oxfordshire, United Kingdom University of Oxford Full time

We are seeking to appoint a Postdoctoral Research Assistant to join the Germline Genomics laboratory led by Dr Anjali Hinch at the Sir William Dunn School of Pathology, University of Oxford.

The laboratory uses a combination of statistical, computational, and experimental approaches to understand how processes in our cells lead to changes in their DNA.

These changes include errors (mutations) or shuffling up of chromosomes (recombination) in human eggs and sperm, which lead to genetic alterations that may be inherited by future generations.

We investigate the mechanisms underlying these changes and their impacts on our health and the evolution of species. Furthermore, we leverage them to understand how mutations arise in cancers.

For example, in our work published recently in _Science_, we show that many mutations, a much higher number than previously thought, are the result of deliberate self-induced damage in our cells.

This leads to mutations in 1 in 4 sperm and 1 in 12 eggs and increases the risk of many diseases, including developmental disorders and cancer.