Senior Scientist, iPSC
1 month ago
Job Description
Our company has a rapidly growing interdisciplinary team of scientists in London and exciting plans to expand our London presence, initially at the Francis Crick Institute as part of our ‘Skylab’ expansion in 2024, and from 2027 in our new ‘state of art’ and fully integrated Research and Discovery Center at the hub of London’s knowledge Quarter, which will be home to approximately 180 scientists alongside other colleagues in discovery research, clinical, regulatory and business roles, including marketing, finance and administration.
Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines through improving our understanding of how our potential new therapies and medicines work at a cellular and molecular level in the patients we serve.
Our London Discovery Centre is seeking a passionate and driven Senior Scientist to join our Neuroscience team based at the London Bioscience Innovation Centre (LBIC) in St. Pancras, London. In this fixed term Senior Scientist position, you will contribute to cutting-edge discovery biology research utilising induced pluripotent stem cells (iPSCs) to investigate neurodegenerative diseases.
You will join a highly collaborative, multi-disciplinary research team and interact with scientists across our Discovery organisation, who have extensive experience in neurodegeneration, cellular biology, in vitro pharmacology, chemistry, and data science.
Responsibilities include but are not limited to:
Maintain human iPSCs and iPSC-derived cells; feeding, passaging, differentiating and plating and establish a QC package for iPSC work.
Design, implement and perform experiments to support the development of drug candidates within iPSC models. These experiments will include high content imaging, functional assays and molecular biological technqiues.
Keep up to date with advancements in the field of iPSC use in neuroscience research and apply relevant knowledge to enhance experimental approaches.
Collaborate with members from other functional areas across our wider networkto drive progress.
Timely write-up of reports and data analysis.
Oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders.
Minimum Education & Experience Minimum Requirements:
Recently completed PhD, or BSc or MSc, in a life sciences discipline (Neuroscience, Biochemistry, or related discipline) with pharmaceutical industry experience.
Required Experience and Skills:
Expertise in human iPSC culture from iPSC maintenance to differentiation into CNS cell types.
Strong scientific understanding of mechanisms of neurodegeneration.
Expertise in molecular biology and microscopy techniques.
Excellent attention to detail in experimental design and data analysis.
Strong interpersonal, verbal, and written communication skills.
Preferred Demonstratable Experience:
Expertise in complex iPSC-derived cell cultures (co-culture to 3D)
Proficiency in use of live cell instruments such as high content imagers, MEAs, and Incucyte.
Demonstrated knowledge of drug discovery and assay development.
Expertise in operating high throughput instrumentation, including plate readers and liquid handling instrumentation.
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Current Employees apply HERE
Current Contingent Workers apply HERE
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Project Temps (Fixed Term)Relocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
Not ApplicableShift:
Valid Driving License:
Hazardous Material(s):
Job Posting End Date:
09/5/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Job Posting End Date:09/05/2024
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R308308
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