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Senior Laboratory Research Scientist – Gene Editing
4 months ago
Description
:Senior Laboratory Research Scientist – Gene Editing Human Biology Facility
Reports to: HBF Head of lab operations
This is a full-time, permanent position on Crick terms and conditions of employment.
Summary
The Human Biology Facility provides support and expertise to enable research utilising human materials and data, and to develop capability in core areas relating to stem cells, genetic modification and human model systems. We provide support to Crick researchers, including our growing number of clinical scientists, throughout the study lifecycle including sourcing human materials, navigating governance frameworks, evidencing compliance, and providing expert technical services. We facilitate access to tissues, data, and expertise that will underpin our research to benefit human health by fostering interactions between our scientists, support teams and external networks. The Facility is comprised of two core functions, a Governance Team, and Human Models Team.
The Models Team collaborates to support, train, educate and provide expert technical services for core areas relating to stem cells and emerging human model systems. This SLRS Gene editing role will sit within the Human Biology Facility (HBF) remit, however, will work in collaboration with the existing Gene Modification Service (GeMS) and the Human Embryonic Stem cell Unit (HESCU). It will provide extensive resources and support to research faculty and staff. The primary focus is on supporting extensive editing work with human cells, particularly pluripotent stem cells (iPSCs), using advanced CRISPR/Cas strategies. Services offered encompass creating custom-edited cell lines with various allele types, stem cell training, and project consultation. With the support of GeMS, you will play a pivotal role in the setup and development of this service for the HBF, including critical infrastructure development, equipment procurement, and laboratory layout design.
Key responsibilities
These include but are not limited to:
Lead and coordinate diverse research projects within the HBF Play a pivotal role in collaboration with Genetic Modification Service to establish and shape Gene Editing for HBF, including critical infrastructure development, equipment procurement, and laboratory layout design. Work collaboratively with the Crick STPs relevant to the running of this service, specifically engaging actively with the Genetic Modification Service on research and design of engineering strategies. Work with Head of Lab Operations and the Head of GeMS to expand a new resource for Group leads Maintain and develop relevant expertise in CRISPR and gene editing used by the science through consultation, literature review and attending scientific meetings. Provide internal and external training in gene editing. Focus on extensive editing work with PSCs, including knockouts, single-base variants, and conditional loss-of-function alleles. Offer stem cell gene editing training and project consultation services to faculty and staff. Efficiently allocate and utilize resources within the facility. Collaborate with several teams across the Crick to advance research and scientific objectives. Innovate to address key scientific challenges necessary for project success, providing candidates with examples or context to understand the scope. Establish and Maintain Policies and Procedures: Implement and manage lab operations, biosafety protocols, and ethical research practices. Write reports, protocols, and Standard Operating Procedures. Deliver Reports and Presentations: Communicate findings effectively to various audiences, including scientific reports, progress updates, and presentations for funding proposals. Foster open communication within the team and with external collaborators.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, open and collegial, in addition to the following:
Qualifications, experience and competencies:
Essential
An MSc/PhD and 5 years experience in a relevant field or equivalent Possess considerable relevant experience with a track record of achievement and demonstrable skill in genome engineering, molecular biology and stem cell techniques Experience with iPSC or human ES cell culture and differentiation and an understanding of the specific challenges associated with these cell types. Extensive experience in cell engineering and genome editing, including CRISPR/Cas strategies. Experienced in the use genome browsers, DNA analysis software and CRISPR/Cas guide on/off target specificity software. Commitment to continued professional development (CPD). Experience of contributing effectively to the work of a team with a flexible and collaborative approach. Able to work independently and drive a project forward through good project planning, time-keeping, organizational and record-keeping skills. An understanding of health and safety requirements in relation to genetic engineering of cell lines Good communication skills, both oral and written with the ability to relay straight forward and complex information to a broad range of stakeholders. Good interpersonal skills enabling the post holder to influence and deliver at all levels Strong planning skills, the ability to prioritize in the face of competing demands, proven success in delivering work personally (and through others) to tight deadlines Good decision-making skills with the ability to use initiative and problem solve
Desirable
Authorship in peer-reviewed publications in internationally recognised scientific journal Experience with the provision of service in a core technologyFind out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here:
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website:
