PhD Biomedical Sciences – ‘Understanding the Role of the Mas Receptor in Demyelinating Disease and Injury’

Found in: beBee S GB - 3 weeks ago

Devon, United Kingdom University of Plymouth Full time

DoS: Dr Eve Kelland (eve.kelland@plymouth.ac.uk)

2nd Supervisor: Professor David Parkinson (david.parkinson@plymouth.ac.uk) 

Applications are invited for a three-year PhD studentship. The studentship will start on 1st October 2024.

Project Description 

Multiple Sclerosis (MS) is a complex neurological disorder with an unknown aetiology and multifaceted pathophysiology. Whilst understanding and therapeutics within this field have been substantial and have improved the lives of many individuals living with MS, there is still an unmet need for interventions that can either protect or repair the nervous system. To develop appropriate therapies that can meet this challenge it is vital that we understand the pathological events following injury and the responses initiated during repair. Our research studies have been focused on components of the renin-angiotensin system (RAS) and have provided significant supporting data to suggest that Mas receptor activation, via therapeutic application of angiotensin 1-7, can provide protection and promote repair following demyelinating injury. However, these studies do not shed light on the role of Mas following a demyelinating injury, whether Mas may have a role in repair and why Mas is expressed on oligodendrocyte lineage cells. Recent research in non-CNS fields of study have suggested that Mas expression is upregulated following injury and may serve to protect or restore damaged tissue. 

For this MS Society awarded Ph.D. studentship the project is centred on determining the kinetics and importance of the Mas receptor in response to myelin damage.  The project will use both in vivo animal models and human adult tissue samples and will utilize a broad range of experimental methodologies including immunohistochemistry, fluorescence and electron microscopy and Western Blot. 

Eligibility 

Applicants should have a first or upper second class honours degree in an appropriate subject or a relevant Masters qualification. 

The studentship is supported for 3 years and includes full Home tuition fees plus a stipend of £18,622 for year 1 (TBC), £19,088 for year 2 (TBC) and £19,565 for year 3 (TBC).  The studentship will only fully fund those applicants who are eligible for Home fees with relevant qualifications.  Applicants normally required to cover International fees will have to cover the difference between the Home and the International tuition fee rates approximately £12,697 per annum 2023/24 rate (2024/25 rate TBC). 

NB: The studentship is supported for three years of the four-year registration period. The fourth year is a self-funded ‘writing-up’ year. 

If you wish to discuss this project further informally, please contact Dr Eve Kelland (eve.kelland@plymouth.ac.uk). 

To apply for this position please click on Apply. 

Please clearly state the name of the DoS and the studentship project title that you are applying for on the top of your personal statement. 

Please see here for a list of supporting documents to upload with your application. 

For more information on the admissions process generally, please visit our How to Apply for a Research Degree webpage or contact the Doctoral College. 

The closing date for applications on Friday 3rd May 2024 at 15:00. Shortlisted candidates will be invited for interview 20th May 2024 shortly after the deadline. We regret that we may not be able to respond to all applications.  Applicants who have not received a response within six weeks of the closing date should consider their application has been unsuccessful on this occasion.

£18,622 to £19,565. The studentship is supported for 3 years and includes full Home tuition fees plus a stipend of £18,622 for year 1 (TBC), £19,088 for year 2 (TBC) and £19,565 for year 3 (TBC)

  • PhD Biomedical Sciences – 'Understanding the Role of the Mas Receptor in Demyelinating Disease and Injury'

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Eve Kelland )2nd Supervisor: Professor David Parkinson ) Applications are invited for a three-year PhD studentship. The studentship will start on 1st October 2024.Project Description Multiple Sclerosis (MS) is a complex neurological disorder with an unknown aetiology and multifaceted pathophysiology. Whilst understanding and therapeutics within this...

  • Professor in Biomedical Science

    3 weeks ago

    Exeter, Devon, United Kingdom European Society of Human Genetics Full time

    We are looking to recruit an outstanding research-focused scientist working in human genetics and genomics to join the Department of Clinical & Biomedical Sciences (CBS) at the University of Exeter Medical School. This is a key strategic position for the Department and the successful applicant will join a vibrant research environment with cutting-edge...

  • PhD Studentship: Investigation the Role of P62-dependent P-bodies in Models of Neurodegeneration

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr. Holly Stephenson (holly.stephenson@plymouth.ac.uk) 2nd Supervisor: Prof. Shouqing Luo (shouqing.luo@plymouth.ac.uk) 3rd Supervisor: Dr. Claudia Barros (claudia.barros@plymouth.ac.uk)  Applications are invited for a three-year PhD studentship. The studentship will start on 1st Oct 2024.   Project Description Neurodegenerative disorders including...

  • PhD Studentship: Investigation the Role of P62-dependent P-bodies in Models of Neurodegeneration

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr. Holly Stephenson )2nd Supervisor: Prof. Shouqing Luo )3rd Supervisor: Dr. Claudia Barros ) Applications are invited for a three-year PhD studentship. The studentship will start on 1st Oct 2024. Project DescriptionNeurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), are a...

  • ResM/PhD Studentship: Isles of Scilly Nematode Diseases of Scented Narcissi: Interdisciplinary Approaches to Diagnosis, Characterisation and Control

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr. George Littlejohn 2nd Supervisor: Dr. Alice Milne (Rothamsted Research) 3rd Supervisor: Prof. Paul Harris (Rothamsted Research) 4th Supervisor: Dr. Claire Kelly Applications are invited for a fully funded 12-18 month (24-36 months part-time) ResM studentship. The studentship will start on 15th September 2024. The ResM studentship may be transferred...

  • ResM/PhD Studentship: Isles of Scilly Nematode Diseases of Scented Narcissi: Interdisciplinary Approaches to Diagnosis, Characterisation and Control

    Found in: beBee jobs GB - 2 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr. George Littlejohn2nd Supervisor: Dr. Alice Milne (Rothamsted Research)3rd Supervisor: Prof. Paul Harris (Rothamsted Research)4th Supervisor: Dr. Claire KellyApplications are invited for a fully funded 12-18 month months part-time) ResM studentship. The studentship will start on 15th September 2024. The ResM studentship may be transferred to the PhD...

  • PhD Studentship: Evaluating the Role of Big Data in Understanding Livestock Impacts on the Upland Landscape

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Mark Whiteside (Email: )2nd Supervisor: Dr Katherine Herborn (Email: )3rd Supervisor: Dr Lauren Ansell (Email: )4th Supervisor: Dr James Buckley (Email: )Applications are invited for a 3.5 years PhD studentship within the Environmental Intelligence doctoral training programme at the University of Plymouth, starting 01 October 2024. Project...

  • PhD Studentship: Evaluating the Role of Big Data in Understanding Livestock Impacts on the Upland Landscape

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Mark Whiteside (Email: mark.whiteside@plymouth.ac.uk) 2nd Supervisor: Dr Katherine Herborn (Email: katherine.herborn@plymouth.ac.uk) 3rd Supervisor: Dr Lauren Ansell (Email: lauren.adams@plymouth.ac.uk) 4th Supervisor: Dr James Buckley (Email: james.buckley@plymouth.ac.uk) Applications are invited for a 3.5 years PhD studentship within the...

  • Professor in Human Genetics

    3 weeks ago

    Exeter, Devon, United Kingdom European Society of Human Genetics Full time

    We are looking to recruit an outstanding research-focused scientist working in human genetics and genomics to join the Department of Clinical & Biomedical Sciences (CBS) at the University of Exeter Medical School. This is a key strategic position for the Department and the successful applicant will join a vibrant research environment with cutting-edge...

  • PhD Studentship: Pancreatic Beta Cell Glucolipotoxicity – How Do Dietary Nutrients Turn Into Toxins?

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    Applications are invited for a three-year PhD studentship in the Mitochondrial Biology group of Dr Charles Affourtit, School of Biomedical Sciences, Faculty of Health. The studentship will start, 1 October 2024. Director of Studies: Charles Affourtit (charles.affourtit@plymouth.ac.uk) 2nd Supervisor: Natasha Hill (natasha.hill@plymouth.ac.uk) 3rd Supervisor:...

  • PhD Studentship: Pancreatic Beta Cell Glucolipotoxicity – How Do Dietary Nutrients Turn Into Toxins?

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    Applications are invited for a three-year PhD studentship in the Mitochondrial Biology group of Dr Charles Affourtit, School of Biomedical Sciences, Faculty of Health. The studentship will start, 1 October 2024.Director of Studies: Charles Affourtit )2nd Supervisor: Natasha Hill )3rd Supervisor: Gary Smerdon )4th Supervisor: Lee Hutt )Project DescriptionType...

  • PhD Studentship: Investigating the Role of Eye Movement in Scleral Growth

    Found in: beBee jobs GB - 2 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Daniela Oehring )2nd Supervisor: Dr Konstantin Glebov )3rd Supervisor: Dr Torsten Bossing )4th Supervisor: Adam Kyte )Applications are invited for a three-year full-time PhD studentship. The studentship will start on 1st October 2024.Project DescriptionAre you fascinated by how our eyes work and eager to make a difference in the fight against vision...

  • PhD Studentship: Investigating the Role of Eye Movement in Scleral Growth

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Daniela Oehring (daniela.oehring@plymouth.ac.uk) 2nd Supervisor: Dr  Konstantin Glebov (konstantin.glebov@plymouth.ac.uk) 3rd Supervisor: Dr Torsten Bossing (torsten.bossing@plymouth.ac.uk) 4th Supervisor: Adam Kyte (adam.kyte@plymouth.ac.uk) Applications are invited for a three-year full-time PhD studentship. The studentship will start on 1st...

  • Deputy Manager

    1 week ago

    Torquay, Devon, United Kingdom The Priory Full time

    We are currently recruiting for a Deputy Manager to support the Service Manager at our serviceNotts Hill House in Torquay, Devon. in ensuring that the home is maintained in accordance with our regulatory bodies as well as to line manage the senior team to ensure high standards of care and service are achieved within the home to regulatory standards. You...

  • PhD Studentship: Monitoring morphological variability of different gravel barrier typologies

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr. Nieves G. Valiente (Email: )2nd Supervisor: Dr. Chris Blenkinsopp (University of Bath)3rd Supervisor: Dr. Mark Davidson (Email: )Applications are invited for a 3.5 years PhD studentship within the Environmental Intelligence doctoral training programme at the University of Plymouth, starting on 01 October 2024. Project DescriptionScientific...

  • PhD Studentship: Establishing the Effect of Microplastic and Nanoplastic Exposure on Inflammatory Bowel Disease

    Found in: beBee jobs GB - 5 days ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Nathaniel Clark )2nd Supervisor: Dr Lee Hutt )3rd Supervisor: Dr Raul Bescos ) Applications are invited for a three-year PhD studentship. The studentship will start, 1 October 2024.Project Description Microplastics (

  • PhD Studentship: Establishing the Effect of Microplastic and Nanoplastic Exposure on Inflammatory Bowel Disease

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    DoS: Dr Nathaniel Clark (nathaniel.clark@plymouth.ac.uk) 2nd Supervisor: Dr Lee Hutt (lee.hutt@plymouth.ac.uk) 3rd Supervisor: Dr Raul Bescos (raul.bescos@plymouth.ac.uk)  Applications are invited for a three-year PhD studentship. The studentship will start, 1 October 2024. Project Description  Microplastics (

  • Lecturer in Environmental Science

    Found in: beBee jobs GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    Faculty of Science and Engineering Based in the Faculty of Science and Engineering, the School of Geography, Earth and Environmental Sciences comprises four distinct areas across the subjects of chemistry, earth sciences, environmental sciences and geography, each delivering exceptional teaching, support and research. All degree programmes are professionally...

  • Lecturer in Environmental Science

    Found in: beBee S GB - 3 weeks ago

    Devon, United Kingdom University of Plymouth Full time

    Faculty of Science and Engineering  Based in the Faculty of Science and Engineering, the School of Geography, Earth and Environmental Sciences comprises four distinct areas across the subjects of chemistry, earth sciences, environmental sciences and geography, each delivering exceptional teaching, support and research. All degree programmes are...

  • Computer Science Teacher

    3 weeks ago

    West Devon, Devon, United Kingdom The Supply Register Full time

    Exciting Opportunity for Computer Science Enthusiasts! Are you passionate about inspiring the next generation of innovators and empowering students to become proficient in the language of technology? We're on the lookout for a dynamic Computer Science Teacher to join the team/ Position: Computer Science Teacher Location: Tavistock - Full time or part...