Associate Director

2 weeks ago


Cambridge Cambridgeshire, United Kingdom Bicycle Therapeutics Full time

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle ® molecules, for diseases that are underserved by existing therapeutics. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist ® (Bicycle TICA ®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle ® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle ® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
The Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists and pharmacologists, they will be responsible for representing DMPK, designing and executing non-clinical studies in support of multiple projects from target identification through to candidate selection and ultimately regulatory submission. 
# Design and implement the appropriate DMPK strategy according to the stage and needs of a project.
# Design experiments, review, interpret and present data at multifunctional project teams.
# Perform DMPK activities including interactions with external CRO’s and internal project stakeholders.
# Work collaboratively with other core disciplines within a project team to support compound progression based on optimizing DMPK properties.
# Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism and excretion.
# Track DMPK budgets for CRO’s and contribute to project spending forecasts.

MSc/PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
# Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem solving and successful delivery across drug discovery.
# Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
# Experience supporting radiopharmaceutical projects desirable.
# State-of-the-art campus environment with on campus restaurant and Montessori nursery
~ Flexible working environment
~ Competitive reward including annual company bonus
~ Employee recognition schemes
~28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
~ Employer contribution to pension (employee does not have to contribute)
~ Life assurance cover 4x basic salary
~ Private Medical Insurance, including optical and dental cover
~ Enhanced parental leave policies
~ Employee assistance program
~ Health Cash Plan
~ Access to company subsidized gym membership
~ Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
~ Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.


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