Research And Development Scientist

2 weeks ago

Slough Berkshire, United Kingdom SRG Full time

Job Title:

Senior/Research Scientist – Mass spec

Contract:

12 months

Location:

Slough

Salary:

£28.09 – 33.58 PAYE, £38.24 Umbrella

SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team. This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group. Key Responsibilities will include:

  1. and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
  2. track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
  3. and prioritise the demands from multiple projects.
Essential Requirements:
  • or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
  • with Waters data processing software packages (PLGS) and DynamX.
  • knowledge Waters HDX-MS system.
  • of structural visualisation tools (PyMOL, Chimera or similar).
  • with HDX-MS experiments using NBE and NCE molecules.
  • organisational, communication, record keeping and team-working abilities.
Desirable Requirements:
  • analysis of membrane proteins.
  • and maintenance of Waters LC/MS equipment.
  • ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
  • track record of publications related to mass spectrometry in peer reviewed journals.
  • of recombinant protein expression systems and PTMs.
  • knowledge of Thermo Scientific Orbitrap MS systems.
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