Vice President, Medical

4 weeks ago

Cambridge Cambridgeshire, United Kingdom Bicycle Therapeutics Full time

Vice President, Clinical Development (MD)
~ Full-time
~ Contract type: Permanent Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA ) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA. Bicycle Therapeutics is seeking a motivated physician leader with oncology drug development experience to serve as Vice President Clinical Development, based in either Cambridge, UK or Cambridge, MA. This leadership role sits within a growing clinical development organization in the oncology space involving several highly novel Bicycle (bicyclic peptide) therapeutics, designed from our proprietary platform. You will report to the Chief Development Officer and directly influence the development of novel molecules of our portfolio in oncology and help to define the broader clinical development strategy. You will collaborate internally with clinical, translational and scientific groups. You will be responsible for study conduct, program activities and clinical development plans across the portfolio. Theidealcandidate will havedeepexpertise inearly to late-stage clinical development and a demonstrable track record ofadvancingprecisionmedicinesfrom bench to bedsideto approvalwith strong scientific rigor andathorough understanding of target and disease biology. As a key member of the Development Leadership Team, you will be responsible for providing scientific, clinical and product development leadership and support for development programs across the Bicycle portfolio. Provide indirect leadership to a cross-functional, matrix team of physicians, clinical scientists and other development teams Provide specific therapeutic area expertise to enhance innovation and efficiency in clinical trial design and execution Responsible for the generation and continual refinement of the clinical development plans for Bicycle’s portfolio from IND to POC to NDA Provide key contribution to IND, NDA, PMA submissions via overseeing medical documentation and active participation in meetings with regulatory agencies Clinical lead for early development study conduct including study design, protocol writing, regulatory documents, CRO interactions, study start up, investigator interactions, data monitoring, health authority interactions, analyses and study reports. Establish and develop relationships with investigators, thought leaders, in close collaboration with the Medical Affairs function Assist in scientific advisory boards, conference activities, external collaborations and partnerships Provide medical, disease-specific, and development perspective into specific research programs or broader research initiatives Medical Doctor (MD/MBBS/DO) degree Ideally a medical oncologist, or possess a deep knowledge and understanding of oncology, including companion diagnostics, precision oncology drug development paradigms, clinical pharmacologyand technical, business, and regulatory approaches Outstanding interpersonal and communication skills both written and oral and ability to communicate complex information clearly and succinctly Effective skills directed toward driving collaboration, achieving results, influencing, and resolving conflicts across internal and external stakeholders In depth understanding of phase I-IV drug development You are passionate about clinical development and precision, and are well connected to external experts and highly credible advisors in the oncology space You have talent and ability in forging and nurturing key partnerships and collaborations with the external scientific community, including academia, governmental organizations, nonprofit organizations and CROs
~ State-of-the-art campus environment with on campus restaurant and Montessori nursery
~ Flexible working environment
~ Competitive reward including annual company bonus
~28 days annual leave in addition to bank holidays+ option to buy up to 5 additional days annually
~ Employer contribution to pension (employee does not have to contribute)
~ Life assurance cover 4x basic salary
~ Private Medical Insurance, including optical and dental cover.
~ Employee assistance program
~ Health Cash Plan
~ Access to company subsidized gym membership.
~ Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
~ Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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