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Scientist - Antibody Humanisation
4 months ago
Are you and experienced Protein or Antibody Biochemist / Engineer looking for your next opportunity to develop within the life sciences sector?
We are currently looking for a Senior Scientist to join the Antibody Humanisation team within a leading life sciences organisation based in the Berkshire area.
Your role as Senior Scientist, Antibody Humanisation will cover various aspects of the antibody development process, including antibody engineering and humanisation design using structural information, antibody cloning and generation of expression plasmids and purification and characterisation of the biophysical properties of candidate antibody molecules.
KEY DUTIES AND RESPONSIBILITIES:
Your duties as the Senior Scientist, Antibody Humanisation will be varied however the key duties and responsibilities are as follows:
1. Design and engineer therapeutic antibodies.
2. Clone and express antibodies in mammalian cell culture (CHO and HEK-293 cells) to provide material for assessment.
3. Use structural insights and computational methods and optimise antibody candidate sequences to improve their eligibility for development.
4. Analyse and interpret data to design next experiments.
5. Collaborate with internal teams to ensure work is carried out to a high standard and achieving agreed timelines.
ROLE REQUIREMENTS:
To be successful in your application to this exciting opportunity as the Senior Scientist, Antibody Humanisation we are looking to identify the following on your profile and past history:
1. Relevant degree, ideally a PhD in a relevant scientific discipline, i.e. molecular biology, structural biology, protein biochemistry. You will also have a working background in molecular biology, protein engineering, antibody engineering and/or structural biology.
2. Experience in antibody cloning/ engineering or biophysical characterisation
3. We are looking for an inquisitive and innovative scientist, with the desire for continuous learning. Excellent communication skills to collaborate with stakeholders. You will have a proactive and positive mindset with a passion for scientific research.
