Senior Bioinformatician/Data Scientist

2 weeks ago

London Area, United Kingdom Northreach Full time

About the Role:

We are looking for an experienced and highly analytical Senior Bioinformatician/Data Scientist to join our research and development team. In this role, you will drive the discovery, development, and curation of gene-editing systems and mobile genetic elements (MGEs), with an emphasis on therapeutic applications. This position offers an exciting opportunity to work at the forefront of bioinformatics, particularly within large-scale metagenomic and microbiome data projects, as we explore new possibilities in gene-editing, viral integration, and secondary metabolite discovery.


Key Responsibilities:

  • Lead research and curation efforts focused on gene-editing systems, moving beyond CRISPR screening to identify and annotate novel gene-editing mechanisms.
  • Apply advanced bioinformatics methods to catalog and characterize diverse gene-editing systems, with a focus on their therapeutic potential.
  • Identify, curate, and analyze MGEs and viral integration events within metagenomic datasets.
  • Develop methods to track and characterize these elements, enhancing understanding of their roles in gene mobility, genomic instability, and therapeutic applications.
  • Conduct comprehensive analyses on large metagenomic and microbiome datasets, utilizing robust computational tools to process and interpret complex data.
  • Generate insights into the microbial ecology, gene function, and genomic context of potential therapeutic elements within microbial communities.
  • Drive research with a therapeutic focus, identifying gene-editing systems or MGEs that can potentially be harnessed for human health applications.
  • Collaborate with interdisciplinary teams to translate findings from metagenomic and gene-editing studies into viable therapeutic candidates.
  • Nice to Have - Biosynthetic Gene Clusters (BGCs) and Secondary Metabolite Discovery:
  • Conduct research in BGCs or secondary metabolite discovery, contributing to the exploration of bioactive compounds within microbial communities.
  • Utilize bioinformatic tools to identify BGCs within metagenomic datasets, exploring secondary metabolites that may possess therapeutic properties.


Qualifications:

  • PhD or Master’s in Bioinformatics, Computational Biology, Genomics, or a related field with strong expertise in gene-editing systems, MGEs, or viral integration research.
  • Extensive experience in large-scale metagenomic or microbiome data analysis.
  • Proven background in developing bioinformatic methods or pipelines for discovery and curation of gene-editing systems beyond traditional CRISPR applications.
  • Knowledge of gene-editing therapeutic applications, MGE biology, and viral integration, with an interest in translational research.
  • Proficiency in bioinformatics programming languages (Python, R, or similar) and experience with large data management and workflow development.
  • Nice to have: Background in BGC or secondary metabolite discovery within metagenomic datasets.


This is a unique opportunity to play a critical role in pioneering therapeutic discoveries in gene editing and microbial genomics. If you’re passionate about advancing bioinformatics for impactful health applications, we would love to hear from you


To apply, please submit your resume detailing relevant experience, and any supporting documents such as publications or project summaries. We look forward to seeing how you can help advance our research frontiers

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