VP, Manufacturing Technology

1 month ago

London, United Kingdom Orchard Therapeutics Full time

Location: London

Reporting to: Chief Technical Officer

Job Summary

 

Orchard Therapeutics, recently acquired by Kyowa Kirin with the goal of accelerating the delivery of new gene therapies to patients around the globe, is looking for a dynamic and experienced Vice President of Manufacturing Technology and Supply. Reporting to the Chief Technical Officer, the role will provide strategic leadership and oversight of all internal and external manufacturing operations as well as global supply chain activities, including the planning and execution of global expansion into new markets, to achieve on-time delivery of high-quality products to patients in the most efficient and cost-effective way.

 

The incumbent will lead the team to successful completion of strategic and pipeline projects through effective project management and identification and escalation of risks. Assigned projects may include technical transfer (analytical/process), execution of regulatory strategies and commitments, process validation, operational efficiency, capacity planning, and distribution. In addition, this person will own and drive program risk management and be accountable for budgetary planning and control.

 

Success in the role will require effective collaboration with all internal functions, particularly Technical Development, Quality and CMC Regulatory and externally with our CDMOs and partners.


Responsibilities

  • Provide strong leadership, set the vision, and architect the path to delivering rapid, flawless, compliant and cost-effective delivery of consistently high-quality products
  • Create world-class, state-of-the-art, cell and gene therapy MSAT and supply chain processes, and associated IT infrastructure. Actively engage in external benchmarking to maintain competitive advantage.
  • Build and develop a highly performing manufacturing and supply chain team that is focused on excellence and continuous improvement
  • Implement and execute upon the manufacturing technology roadmap
  • As the head of the function, provide leadership and direction, lead critical milestone reviews, decision making, issue resolution, risk mitigation and continuous improvement of processes to ensure commitments are met
  • Effectively communicate with team members, and key stakeholders on the status, objectives, risks, and mitigation plans associated with projects, mentor and coach the team
  • Build strong collaborative relationships with internal and external stakeholders to ensure effective and reliable demand forecasting and supply planning that ensures adequate manufacturing capacity and adequate product and raw material inventory availability at the right time
  • Work closely to support GMP and non-GMP production activities and product distribution activities and support functional areas during long range planning / budget planning
  • Assist in the creation and deployment of standards around project and workload management to improve efficiency, expand functional capabilities and streamline use of resources
  • Ensure that department objectives are in line with company objectives and be fully accountable to achieve goals, strategic directives and ensure that targeted project milestones are met within agreed upon timelines
  • Serve as a role model to foster a culture of high performance and trust

Requirements

 Knowledge & Experience

  • Substantial experience in the pharmaceutical industry leading manufacturing science and technology (MSAT/ASAT) within a CGT environment ensuring strong and robust manufacturing and analytical processes are delivered
  • Proven expertise in leading and developing global supply chain activities within CGT
  • Proven experience and knowledge in the development and scale up of HSC and LVV manufacturing processes
  • Experienced in building strategic partnerships with external manufacturers/CMOs and service providers to ensure successful and effective execution on strategic plans
  • Working knowledge of biotechnology, GMPs, and drug development pathway through to commercialization
  • Experienced in leading the implementation of processes, SOPs, and IT systems to support manufacturing and supply chain processes
  • Proven track record of independently managing and successfully driving complex projects within the biotech industry. Able to work effectively in cross-functional, matrixed environment, prioritizing and managing multiple projects simultaneously, integrating cross-functional issues and balancing competing priorities effectively.
  • Prior experience and involvement in regulatory submissions and risk management

Skills & Abilities

Setting Strategy

·         Able to create and articulate an inspiring vision and collaborate cross-functionally on broader technical strategies and business decisions

·       Takes an entrepreneurial and creative approach to developing new, innovative ideas that will optimize and challenge the status quo to reach better results

·         Demonstrates technical proficiency, business acumen, independent thought and learning agility

 

Executing for Results

·         Sets clear and challenging goals while committing the organization to improved performance

·         Expert at aligning functional objectives with business goals with a strategic and detail-driven approach

·         Comfortable with ambiguity and uncertainty; able to make decisions through complex situations

·         Makes sound decisions regarding complex technical issues and communicates decisions effectively with internal stakeholders, elevating complex issues as appropriate

·         Tenacious and results focused with advanced ability to manage and prioritize multiple key projects and consistently meet deadlines

·         Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective.

·         Able to manage budgets, resources, and associated project plans for area of responsibility with internal and external stakeholders

 

Leadership, Collaboration, and Influence

·         A strong and inspiring people leader with a coaching style and the ability to build high performing teams

·         A thoughtful and pragmatic communicator and influencer with proven ability to build effective relationships internally and externally to the organization that enable strong collaboration between all key stakeholders to achieve critical milestones

Education

·         BSc in a relevant scientific discipline such as Biotechnology, Chemistry, Biochemistry, Molecular Biology, Cell Biology, Chemical Engineering, or another relevant field

  • Director of Technology

    5 days ago

    london, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringSalary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to work...

  • Director of Technology

    4 days ago

    London, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringMake sure to read the full description below, and please apply immediately if you are confident you meet all the requirements.Salary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business...

  • Director of Technology

    4 days ago

    London, United Kingdom Finatal Full time

    Job DescriptionTitle: Director of Technology / VP of EngineeringSalary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of...

  • Director of Technology

    5 days ago

    London, United Kingdom Finatal Full time €170,000

    Title: Director of Technology / VP of Engineering Salary: £170k + Bonus London Permanent HL10984 Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to...

  • Director of Technology

    5 days ago

    London, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringMake sure to read the full description below, and please apply immediately if you are confident you meet all the requirements.Salary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business...

  • Director of Technology

    5 days ago

    London, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringSalary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to work...

  • Director of Technology

    4 days ago

    London, United Kingdom Finatal Full time €170,000

    Title: Director of Technology / VP of Engineering Salary: £170k + Bonus London Permanent HL10984 Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to...

  • VP, Manufacturing Technology

    1 month ago

    London, United Kingdom Orchard Therapeutics Full time

    Location: LondonReporting to: Chief Technical OfficerJob SummaryOrchard Therapeutics, recently acquired by Kyowa Kirin with the goal of accelerating the delivery of new gene therapies to patients around the globe, is looking for a dynamic and experienced Vice President of Manufacturing Technology and Supply. Reporting to the Chief Technical Officer, the role...

  • VP, Manufacturing Technology

    1 month ago

    London, United Kingdom Orchard Therapeutics Full time

    Location: London Reporting to: Chief Technical Officer Job Summary Orchard Therapeutics, recently acquired by Kyowa Kirin with the goal of accelerating the delivery of new gene therapies to patients around the globe, is looking for a dynamic and experienced Vice President of Manufacturing Technology and Supply. Reporting to the Chief Technical Officer,...

  • VP, Manufacturing Technology

    6 hours ago

    London, United Kingdom Orchard Therapeutics Full time

    Location: London Reporting to: Chief Technical Officer Job Summary Orchard Therapeutics, recently acquired by Kyowa Kirin with the goal of accelerating the delivery of new gene therapies to patients around the globe, is looking for a dynamic and experienced Vice President of Manufacturing Technology and Supply. Reporting to the Chief Technical Officer,...

  • Technology Auditor

    8 hours ago

    London, United Kingdom Lutine Bell Full time

    Lutine Bell are working with a leading UK Pensions Insurance organisation who are looking to appoint a Technology Auditor AVP/VP to join their team. Execute integrated and technology specific audits covering business and technology applications, distributed platforms, information security, infrastructure, and public cloud. Work as part of a team working...

  • Technology Auditor

    2 weeks ago

    London, United Kingdom Lutine Bell Full time

    Lutine Bell are working with a leading UK Pensions Insurance organisation who are looking to appoint a Technology Auditor AVP/VP to join their team. Execute integrated and technology specific audits covering business and technology applications, distributed platforms, information security, infrastructure, and public cloud. Work as part of a team working...

  • Director of Technology

    4 days ago

    London Area, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringSalary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to work...

  • Director of Technology

    4 days ago

    London Area, United Kingdom Finatal Full time

    Title: Director of Technology / VP of EngineeringSalary: £170k + BonusLondonPermanentHL10984Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to work...

  • Director of Technology

    4 days ago

    London Area, United Kingdom Finatal Full time

    Title: Director of Technology / VP of Engineering Salary: £170k + Bonus London Permanent HL10984 Finatal are currently exclusively working with a global midmarket Private Equity Fund that operates within technology/software, business services industries. With over £1 billion AUM they are now looking for a Director of Technology or VP of Engineering to...

  • Director or VP

    2 weeks ago

    London, United Kingdom Discovered MENA Full time

    VP / Director of Digital and MarTech (Based in Riyadh, KSA) VP / Director of Digital and MarTech (Based in Riyadh, KSA) Sign in to save VP / Director of Digital and MarTech (Based in Riyadh, KSA) at Discovered MENA . Do you want to work for a groundbreaking giga project in KSA as one of the founding team? We are seeking a VP / Director of Digital,...

  • VP Finance

    3 weeks ago

    London, United Kingdom Gorilla Full time

    Climate change is changing the world faster than ever before. Utilities will play a crucial role in the transformation of our society to fight climate change and become carbon-neutral, while at the same time making sure people and businesses can continue to use energy supply like they've been used to for so many years. At Gorilla, we're determined to not...

  • VP Finance

    1 week ago

    London, United Kingdom Gorilla Full time

    Climate change is changing the world faster than ever before. Utilities will play a crucial role in the transformation of our society to fight climate change and become carbon-neutral, while at the same time making sure people and businesses can continue to use energy supply like they've been used to for so many years. At Gorilla, we're determined to not...

  • Healthcare/Consumer/Technology M&A VP

    4 days ago

    London, United Kingdom Agora Talent Full time

    This is an opportunity for a mid-market, sell-side M&A focussed Vice President (you may be a generalist, in Consumer, Technology or other industry teams) to re-align to a very active and stimulating Healthcare sector. This Healthcare team have grown throughout the lower periods of deal activity in recent times, and you will gain valuable exposure to...

  • Healthcare/Consumer/Technology M&A VP

    1 week ago

    London, United Kingdom Agora Talent Full time

    This is an opportunity for a mid-market, sell-side M&A focussed Vice President (you may be a generalist, in Consumer, Technology or other industry teams) to re-align to a very active and stimulating Healthcare sector. This Healthcare team have grown throughout the lower periods of deal activity in recent times, and you will gain valuable exposure to...