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Sutton Coldfield, Birmingham, United Kingdom The Institute of Cancer Research Full timeAbout the RoleWe are seeking a highly experienced and skilled Team Leader to join our Centre for Cancer Drug Discovery as the Head of Biology and Director of the Centre for Target Validation.Key ResponsibilitiesLead a team of researchers in the discovery and development of novel cancer therapiesDevelop and implement innovative drug discovery strategies and...
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Higher Scientific Officer, Biology, Centre for Target Validation
4 months ago
We are seeking to appoint a Higher Scientific Officer within the Centre for Target Validation to carry out lab-based cell biology research focused on potential therapeutic targets in cancer. Projects will involve the use of genetic techniques (RNAi/CRISPR), targeted protein degradation, tool compounds and molecular biology to generate key decision-making data in target validation and enable target prioritisation for drug discovery. The post holder will also contribute to assay development and biomarker discovery for targets that move to a drug discovery phase within the ICR’s Centre for Cancer Drug Discovery.
Key Requirements
The successful candidate must have at least a Masters level qualification in Cell Biology or an aligned subject, a knowledge of cancer biology and a knowledge of experimental approaches to therapeutic target validation in cancer. The candidate must also have the essential skills and experience needed to carry out lab-based biology research for cancer target validation:
Skills in cell biology techniques used for target validation Expertise in a range of biology readouts used for screening and biomarker detection Excellent record keeping skills High motivation and a strong desire to achieve scientific excellence, prioritising quality and reproducibility of results Experience working in lab-based cell biology (can include PhD)Department/Directorate Information
The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for launch of drug discovery projects. The Centre’s dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR’s Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust, targets into drug discovery programmes in the ICR’s Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners.
