Senior Full Stack Developer

4 weeks ago

Hinxton, United Kingdom Embl-Ebi Full time

Your role

This is an exciting opportunity to make a significant contribution to development of a new open-source Perturbation Catalogue for harmonised and curated human gene (e.g. CRISPR), variant (e.g. MAVE), and expression (e.g. Perturb-seq) data. This project is funded through the consortium, an innovative public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation. The new resource will help to address a fundamental need in the scientific and drug discovery community for a comprehensive resource to understand the impact of modifying genes and proteins.

You will be responsible for support and development of software to handle programmatic access and a portal interface to explore, combine, visualise and access a wealth of perturbation data. This will enable the extension and application of existing algorithms and the design of new computational methods for functional genetics and target identification and prioritisation, offering enhanced statistical power and the capability to work with disease subtypes at a finer granularity. The Perturbation Catalogue will deliver rich community standards, open-source harmonisation and meta-analysis software, gold standard machine learning ready datasets, and a highly customisable public cloud platform with distributed data warehousing technology for cross metadata queries.

You will interact closely with the team’s Biocurator for data coordination into the perturbation data portal, as well as with the wider Human Genomics team. You also will work collaboratively within the Open Targets Perturbation Catalogue project team, alongside scientists, developers and data engineers from EMBL-EBI, Wellcome Sanger Institute, Human Technopole, and industry partners (GSK, Pfizer, Genentech, Sanofi, MSD) to gain their respective expertise and requirements.

Closing date: 30 June 2024

Contract duration: 3 years (project based contract)

Grading: Grade 6 (monthly salary starting at £3,456 after tax) plus other paid benefits depending on personal circumstances

Reference number: EBI02256

Related

You have

A BSc or MSc in computer science or related fields. Expertise in Python, including popular Python libraries: NumPy, Pandas, PySpark and frameworks: Django, Django Rest Framework, FastAPI Hands-on experience with both relational (e.g. PostgreSQL) and non-relational databases (e.g. Elasticsearch, Redis). Strong experience in data warehousing architecture, big data processing and ETL Unix/Linux environments GIT and working in collaborative software environments Willingness to learn new skills as the project requires Self-motivated and capable of working both independently and as part of a team Excellent communication, interpersonal and English language skills

You might also have

Experience developing or maintaining web-based applications (html, css, Javascript frameworks such as Angular, React) Cloud (GCP or AWS) and popular cloud Big Data tools - BigQuery, Dataflow, Looker Containerisation (Docker or similar) and orchestration (k8s) Experience of processing biological archive data Tests and CI/CD

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