LC-MS Scientist

2 weeks ago

Macclesfield, United Kingdom CK Science Full time

LC-MS Scientist

CK Group are recruiting for a lab-based LC-MS Scientist to join a precision medicine company based near Manchester.

Company:

Our client is developing next-generation diagnostic tests to help clinicians prescribe the right drug, for the right patient, at the right time. They are developing LC-MS proteomic biomarker discovery platforms and clinical assays to predict drug response in a clinical setting.

The Role:

Support the development of biomarker discovery platforms and resulting clinical assays. Be involved in a variety of projects that aim to expand the portfolio of proteomic assays Sits within the LC-MS/MS technical operations team and involves operation of LC-MS/MS systems and method development

Your Background:

Ph.D. in proteomics or protein biochemistry applied to the investigation of mammalian cell biology Expertise in LC-MS/MS proteomics - hands-on experience running/operating high-end LC-MS/MS systems (including hands-on experience calibrating the MS systems, basic maintenance of LC-MS/MS, renewing buffers, running QCs, interpreting data, and reporting QC outputs). Experienced in preparing samples using proteomic workflows for LC-MS/MS analysis. Experience working with multiple sample types (e.g. cell lines, blood, solid tissue). Knowledge and understanding of fundamental principles of biochemical and molecular biological systems. 

Desirable:

Experience analysing large sample sets, across multiple batches. Experience using software for the identification, characterisation and quantification of peptides and proteins from LC-MS/MS raw data. Expertise in the utilisation of LC-MS/MS proteomic technologies for the identification and validation of clinical biomarkers. Experience in automation of sample preparation workflows using liquid handlers. Experience building targeted (e.g., PRM/SRM) or untargeted (e.g., DDA/DIA) methods for proteomics. 

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