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    {"title": "Lead Genomic Data Scientist", "description": "Job SummaryWe are seeking a highly skilled Lead Genomic Data Scientist to join our Bioinformatics Consulting team at Genomics England. The successful candidate will lead on a range of cancer genome analysis and interpretation projects, collaborating with external researchers and industrial partners.Key...

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Senior Genomics Data Scientist

3 months ago

London, United Kingdom ZipRecruiter Full time

Job Description

Company Description
Genomics England partners with the NHS to provide whole genome sequencing diagnostics. We also equip researchers to find the causes of disease and develop new treatments – with patients and participants at the heart of it all.
Our mission is to continue refining, scaling, and evolving our ability to enable others to deliver genomic healthcare and conduct genomic research.
We are accelerating our impact and working with patients, doctors, scientists, government, and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

Job Description
We are seeking a Senior Genomics Data Scientist to join our Bioinformatics Consulting team at Genomics England and lead on a range of genome analysis and interpretation projects with an emphasis in rare or complex disease, in collaboration with and on behalf of our external researchers and industrial partners.
In this role, you will develop and execute cutting-edge statistical and computational genomics analyses that leverage Genomics England datasets to address a broad set of research questions.
You will drive projects from conception to completion and lead the scoping and implementation of state-of-the-art statistical and computational approaches for analysis of genomic and other omics modalities. You will develop and fine-tune tools and pipelines to carry out custom analyses on demand in our research environment, generate new data and disseminate findings in publication-quality reports and documentation.

Everyday responsibilities include:

  1. Performing custom computational analyses on whole genome sequencing and other omics datasets, including genome-wide association studies, aggregate variant association testing, meta-analysis, transcriptome-wide association studies, fine-mapping, and MR.
  2. Preparing statements of work for projects and delivery of publication-level quality reports of the findings and analyses, with minimal supervision.
  3. Preparation of data for downstream analysis, e.g. through quality control, functional annotation, and harmonisation across different datasets.
  4. Researching the scientific literature, identifying and implementing new approaches to genome analysis, as well as contributing to the publication and dissemination of our learnings in the form of scientific papers, white papers, and conferences.
  5. Providing computational genetics expertise to utilise the right tools for each analysis and support internal teams and commercial clients, being the point of reference for genomic datasets and analytical approaches.
  6. Benchmarking and improving tools for processing and analysis of whole genome sequencing data.

Skills and Experience for Success
We anticipate the ideal candidate will have:

  1. Strong programming skills (R, Python) and demonstrable knowledge of statistical genetics.
  2. Demonstrable experience in using next sequencing data at scale in the context of human genetics.
  3. Strong background in human disease genetics, preferably in rare or complex disease, demonstrated by leading high impact publications or industry track record.
  4. Demonstrable experience in one or more areas of human germline DNA analysis such as genetic association testing, population genetics, pharmacogenomics, rare disease genomics, risk score prediction, structural variation analysis, working with complex genomic regions such as HLA/KIR.
  5. Experience with working in the cloud, building containers, and running pipelines in Nextflow.
  6. Proven ability to communicate with stakeholders from diverse backgrounds (e.g. management, IT, R&D, biology, bioinformatics) and a clear understanding of clinical and phenotypic data management and the sensitivities surrounding patient cohort data.
  7. Excellent interpersonal skills, keeping track of customer relationships, providing high calibre troubleshooting, identifying unmet customer needs, and suggesting solutions to improve material or analytical approaches.

Qualifications
A PhD in Computational or Statistical Genetics with extensive post-doctoral or equivalent work experience in human genetics research.

Additional Information
Salary from £62,000
Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:

  • 30 days’ holiday (plus bank holidays), with additional days for long service awards
  • A generous pension scheme of up to 15% combined contribution
  • Life Assurance (3 x salary)
  • Individual learning budgets for every colleague, a Blinkist account and a wide variety of courses on our portal
  • A wide variety of wellness benefits including Gympass, a Headspace account, free weekly Yoga classes
  • Enhanced maternity & paternity benefits
  • Blended working arrangements

Talk to our Talent Team and find out how a career with Genomics England will benefit you.

We are aware of an ongoing issue with our application portal which is leading to some applications not being received. We are investigating this, but in the meantime, if you do not receive an email confirming your application was successful please email (url removed) with your CV and any cover note you wish to add, to ensure you are considered for the role.

#LI-Hybrid
Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, and best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any social background. Genomics England’s policies of non-discrimination and equity will be applied fairly to all people, regardless of any relevant factor.

Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work.

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