Clinical Scientist

2 weeks ago

London, United Kingdom Great Ormond Street Hospital Full time
Job overview

Our scientific teams have developed significant expertise and have established close working relationships with our clinical colleagues to ensure that our patients benefit from the information generated by WGS. To be able to grow the service and enable prompt adoption of testing in newly-eligible tumour types, we are now looking for a Clinical Scientists to join our team dedicated to the WGS service. 

The main focus of the role will be the analysis and interpretation of WGS data for cancer patients (solid and haematological malignancies in both paediatric and adult patients) and presentation of the findings to scientists, clinicians, clinical geneticists and genetic counsellors at our regular Genomic Tumour Advisory Boards (GTABs). Working across the North-Thames GLH, WGS-scientists will interact with scientific and clinical colleagues from the GLH as well as the partner laboratories and referring hospitals to support a pan-GLH service.

An understanding of and proficiency in variant classification for somatic and/or germline findings according to published guidelines is required and experience in analysis of complex genetic data, from WGS (including the 100K project), would be an advantage.

We welcome applications from registered clinical scientist working in cancergenomics or genetics with an interest in acquired diseases. 

It is anticipated that interviews will be held week commencing 24th June.

Main duties of the job

·         To follow established procedures and protocols

·         Comply with health and safety policies

·         Comply with corporate and professional codes of conduct

·         Assist in quality assurance procedures

·         Assist in training of new staff or visitors

·         To generate and interpret results, to classify genomic variants, to calculate risks where necessary, and to produce clear and concise patient reports adhering to agreed templates and sample turnaround times as directed by the Head of Service. The focus of this role will be on the analysis of whole-genome sequencing analysis with presentation of cases at GTAB and issuing of reports

·         To participate in the training and supervision of other members of staff and visitors

·         To prepare for and participate in multidisciplinary meetings with other members of staff, clinicians and staff from other scientific disciplines as required.

·         To undertake additional responsibilities as directed by the Head of Service, for example Deputy Safety Officer

Working for our organisation

GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.


We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.
We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.


We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.


We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women’s staff networks.

Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust’s mission, values and efforts specific to inclusion. All of our staff networks are open to any employee

Detailed job description and main responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below

Person specificationGOSH Culture and ValuesEssential criteria
  • Our Always values
Academic/Professional qualification/TrainingEssential criteria
  • BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience
  • HCPC Clinical Scientist Registration Certificate
Desirable criteria
  • Postgraduate qualification in Genomics
Experience/KnowledgeEssential criteria
  • Experience working in a clinical diagnostics/ genomics laboratory
  • Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
  • Experience of writing clinical genetics reports
  • Knowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing data
  • Track record of scientific Publications/ presentations
Desirable criteria
  • Experience in the analysis and reporting of whole genome sequencing data
  • Evidence of supervising/training other staff
  • Experience with laboratory information and quality management systems
Skills/AbilitiesEssential criteria
  • Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
  • Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
  • Computer literate, including use of Genetic databases, analytical software, variant classification
  • Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
  • Able to write protocols
Desirable criteria
  • Background in cytogenetic and molecular procedures
 

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