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Research Assistant OR Research Associate in Proteomics and Transporter Kinetics

2 months ago

Manchester, United Kingdom The University of Manchester Full time

We are seeking a talented and enthusiastic Research Assistant / Research Associate to join the CAPKR at the University of Manchester. The successful candidate will become a member of the CAPKR research team and be fully involved in a project entitled “Defining Local Disposition Beyond What is Known for Small Molecules to Assist Building PBPK Framework for Oligonucleotide and Antibody Drug Conjugate Modalities”. Small molecules have dominated drug therapy for over a century, but recent decades have seen the development of increasingly larger and more sophisticated drug types. These include both protein or peptide based drugs, such as antibodies, and oligonucleotides. The distribution of such molecules within cells, such as liver cells, is not well-understood. Oligonucleotides, for example, are known to distribute in lysosomes, cytoplasm and nucleolus.

In this project we will focus on oligonucleotides and on antibody-drug conjugates (ADCs) with the aim of understanding their disposition within cells, and eventually of building physiologically-based pharmacokinetic models enabling us to predict the effects of these compounds on various groups of patients.

This project spans two years with the following aims:

Analysis of copious proteomic data held within CAPKR for receptors and transporters relevant to oligonucleotides and ADCs. Data pertaining to both healthy tissue and various diseases are available. Determination of abundances of receptors and transporters that facilitate cellular uptake of prototype oligonucleotides and ADCs Identification of cellular binding, uptake and disposition of oligonucleotides and ADCs by identified receptors and transporters. Finally the data collected above will be used to develop a physiologically-based pharmacokinetic model for the distribution of oligonucleotides and ADCs.