Senior Scientist
2 months ago
The Role:
We are searching for an experienced phage display scientist to join the Protein Binders team, part of our Platform Technology division at Nxera Pharma. The successful candidate will use phage display expertise to identify protein binders against therapeutic membrane protein targets to enable structure determination and drug discovery efforts. The candidate will work in interdisciplinary teams in a project-centric fashion, with the aim of accelerating the development of life-changing medicines.
The role will include the following responsibilities:
- Employing phage display technology to select protein binders against membrane protein targets
- Screening and validating hits using high-throughput assays e.g. ELISA formats, BLI, cell binding assays
- Subcloning of plasmid constructs for expression and protein engineering of VHH frameworks
- Biophysical evaluation of VHH hits
- Sharing your expertise, insights, and ideas with the team, project, and department to positively influence project success.
Requirements:
- PhD (or MSc/MRes with equivalent lab experience) in a relevant area of biology with demonstrable industry experience carrying out phage display campaigns
- Theoretical and practical expertise in phage display technologies and selection techniques
- Experience working with phage antibody libraries and preferably VHH display
- Strong and evidenced molecular biology proficiency
- Demonstrable expertise in protein-protein interaction screening techniques
- Analytical thinker with good problem-solving skills
- Strong interpersonal skills and ability to interact effectively with scientists across disciplines to generate timely and informative data.
Desirable Experience:
- Measuring affinity using either BLI or SPR
- Affinity maturation
- Library build (either affinity maturation or immunised, naïve or synthetic libraries)
- Working with membrane proteins (in particular GPCRs)
- Having computational expertise in protein binder design would be extremely beneficial.
Fantastic benefits on offer include:
- State-of-the-art R&D centre located in the heart of the Cambridge science cluster.
- Competitive compensation package including discretionary bonuses.
- 25 days annual leave in addition to public holidays.
- Employer contribution to pension.
- Private Medical Insurance and a cash plan for dental and optical reimbursement.
- Health and wellbeing benefits including a subsidised individual gym membership.
- Income protection to cover long-term absences due to ill health.
- Group Death in Service equal to 4x basic annual salary.
About Us
Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally.
Nxera employs over 350 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565).
In addition to several products being commercialized in Japan, we are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies including Lilly, GSK, AbbVie, Verily, Neurocrine, Takeda, Genentech/Roche, Pfizer, Boehringer Ingelheim, Medicxi, Aditum Bio.
This pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of our unique and industry leading GPCR-targeted structure-based drug discovery “NxWave” platform to provide a sustainable source of best- or first-in-class candidates.
In Cambridge UK, we have built outstanding capabilities across our platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development.
In Tokyo, our expert teams are dedicated to late-stage development (Ph 2/3) and innovative commercialization/ go-to-market approaches.
Our Mission
To accelerate the development of life-changing medicines, by investing in science and technology
Our Vision
To lead the next era of medicine. From Japan, for Japan, and the world.
Our Values
- Patients, carers, families, and physicians come first
- Innovation and teamwork inspire success
- Focus on top priorities where we can make a difference
- Speed and agility of decision-making
- Operational excellence
We are passionate about improving the quality of life and health of people around the world and believe we can achieve our mission through providing a supportive, motivational, and empowering environment for employees.
We are proud to offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance.
You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.
For more information, please visit:- www.nxera.life
How to apply? Please send your CV and Cover letter to Sav Bassi at sav.bassi@ext.nxera.life.
Note to Agencies: We have a preferred supplier whom we will use if needed; please do not contact us about this role.
-
Senior Data Scientist
2 months ago
UK, UK, United Kingdom Oliver Bernard Full timeSenior Data Scientist - Up to £150,000 - Fully Remote Salary: Paying Up to £150,000Working Arrangements: Fully RemoteMust have suitable Right To Work, No SponsorshipThe CompanyAn industry leading gaming company are looking for a Senior Data Scientist to join their small but established team. This award winning firm are continuing the grow their presence on...
-
Senior Research Scientist
4 weeks ago
UK, UK, United Kingdom Hyper Recruitment Solutions Full timeWe have an exciting opportunity for a Senior Research Scientist - Microbiology to join a leading biopharmaceutical company based in the Cambridgeshire area. As the Senior Research Scientist - Microbiology, you will be joining the pre-clinical development team and be responsible for contributing to the advancement of cutting-edge microbiology-based...
-
Senior Data Scientist
2 months ago
UK, UK, United Kingdom Harnham Full timeSenior Data ScientistUp to £90,000London (Hybrid, 3 days onsite) Company:This company is a global creative consultancy that partners with huge companies such as Mastercard, SAMSUNG, Mercedes, and Virgin Media! They are looking for a Senior Data Scientist to join their team, who has a great generalist background to work on a variety of exciting projects as...
-
Senior Data Scientist
2 months ago
UK, UK, United Kingdom Harnham Full timeSENIOR DATA SCIENTISTUP TO £70,000HERTFORDSHIRE - HYBRID - 3X A WEEK*Please note, this company is unable to offer sponsorship and you must be a UK resident to apply*Company:This company is a global leader in Customer Data Science, who work across customer analytics and loyalty working as a consultancy services giving you’re the opportunity to work with...
-
Senior Data Scientist | AI
2 months ago
UK, UK, United Kingdom Nicholson Glover Full timeSenior Data Scientist | AI Tech Scale-Up | London/Hybrid | Up to £80,000 + Equity We are excited to be working with a rapidly growing AI Tech Scale-Up looking to expand its team with a talented Senior Data Scientist!About the CompanyThis innovative company offers an advanced enterprise platform that delivers predictive analytics and provides actionable...
-
Senior Scientist
4 weeks ago
UK, UK, United Kingdom Yourgene Health Full timeJob title: Senior Scientist (NGS/Next Generation Sequencing team)Reports to: NGS Team LeaderLocation: Manchester Science ParkContract Type: Full-time, PermanentSalary & Benefits: Competitive Salary + Benefits PackageAbout Yourgene Health:Yourgene Health is a leading integrated technologies and services business, enabling the delivery of genomic medicine. The...
-
Senior Research Scientist
2 weeks ago
UK, UK, United Kingdom Harnham Full timeSenior Research ScientistSalary up to £85,000Remote in UKJoin a dynamic team of Scientists working on high-impact, ML projects with a focus on family planning and contraceptives in low-income countriesROLE AND RESPONSIBILITIESWorking closely within a small team, to design and build models across regression, segmentation, clustering and survey analysis using...
-
Senior Biomedical Scientist
2 months ago
UK, UK, United Kingdom Nuffield Health Full timeSenior Biomedical Scientist - HistologyNuffield Health Tunbridge Wells Hospital Permanent | Full-Time (37.5 Hours)£45,000 (DOE)To look after the nation’s heath, we must provide the highest standards of care. So, we need to work with the best talent around. That’s why we’re looking for someone who understands how important it is to maintain great...
-
Clinical Scientist
1 month ago
UK, UK, United Kingdom Skills Alliance Full timeCurrently hiring for a Clinical Scientist or Senior Clinical Scientist to join the team of a clinical-stage biopharmaceutical company developing next-generation, programmed T cell therapies for the treatment of cancer. This is a 12-month contract opportunity with potential to go permanent. The current position will be in clinical development in the area of...
-
Senior Data Scientist
2 months ago
UK, UK, United Kingdom Harnham Full timeSENIOR DATA SCIENTISTLONDON (HYBRID - 3 Days Per Week)UP to £70,000COMPANY:This company is a global leader in Customer Data Science, who work across customer analytics and loyalty working as a consultancy services giving you’re the opportunity to work with market leading business & retailers!They are looking for a Senior Data Scientist to join their Data...
-
Senior Data Scientist
2 months ago
UK, UK, United Kingdom Harnham Full timeSenior Data ScientistUp to £70,000LondonDriving innovation with advanced data science to transform the customer experience and deliver impactful solutions.COMPANYOur client is a global leader in Customer Data Science, empowering businesses worldwide to thrive in the modern data-driven economy. Their mission is to help businesses grow and reimagine...
-
Senior Scientist
1 month ago
UK, UK, United Kingdom Planet Pharma Full timePlanet Pharma is currently recruiting for a Senior Scientist to work for a leading organisation in London.It is essential you hold the following:Bioconjugation experience is essential - Lysine, inter-chain cysteine, site specific cysteine etc.Nice to have but not essential (NTHVNE) - ADC experienceNTHVNE - Protein purification, Analytical Characterisation...
-
Sr. Scientist Immunoassay
3 months ago
UK, UK, United Kingdom Resolian UK Full timeThe focus of this role is scientific leadership and oversight of development and validation within our immunogenicity group, within the wider immunoassay department. You will be responsible for helping us to deliver high quality ADA method and sample analysis results to our customers in compliance with GLP/GCP. Senior Scientists are capable of working with...
-
Fermentation Scientist
4 weeks ago
UK, UK, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full timeOur client, a growing biotechnology company, is searching for a Fermentation Scientist to join their team. You will be involved in both new and ongoing R&D projects focused on process development and optimisation, with the opportunity to make a meaningful impact on a rapidly expanding organisation.Fermentation Scientist responsibilitiesThe successful...
-
Data Scientist
2 months ago
UK, UK, United Kingdom Harnham Full timeDATA SCIENTISTUP TO £60,000 + 50% BONUSOXFORD - 5 Days a weekTHE COMPANYI am supporting a bespoke games studio on a key Senior Games Analyst hire. Within this role you will analyse game performance, performing deep dive analysis to improve user experience.THE ROLEThe successful Senior Games Analyst responsibilities will include:Create and sustain queries...
-
Data Scientist
1 month ago
UK, UK, United Kingdom Bioscript Group Full timeThe RoleThe Senior Data Scientist supports the management, development and execution of the Data Insights Team by playing a pivotal role in helping shape our data strategy, designing, and implementing advanced data analytics solutions for the whole Bioscript Group.Key Responsibilities/Accountabilities Leadership and Strategy:Manage data scientists, providing...
-
Senior protein engineer
2 months ago
London, UK, UK, United Kingdom Scindo Full timeCarbon chains are the backbone of much of modern life – from crude oil to materials and ingredients. We are working towards a future without worthless carbon, where there is no one way streets leading to landfills. Scindo is developing enzyme processes and cell-free manufacturing to enable sustainable feedstocks to replace petrochemical products.We are...
-
Senior Director, Clinical Research Scientist
2 months ago
UK, UK, United Kingdom Advanced Clinical Full timeSenior Director, Clinical Research Scientist - OncologyGlobal Pharma company This position is responsible for collaborating with physicians in Clinical Development to deliver clinical research support for assigned programs, based on phase or therapeutic area.Essential Functions of the Job 1. Develop protocols for clinical studies.2. Contribute to the...
-
Principal Scientist Gene Therapy
1 month ago
UK, UK, United Kingdom AAVantgarde Bio Full timePosition Summary:This is a position for a skilled scientist and intrapreneur you loves to push a Research project from inception to its end.We need an agile, innovative, team player and well versed scientist in Gene Therapy, who enjoy to drive a project in Research from inception to its hand-over to the preclinical team, especially through transgene design...
-
Senior Analytical Chemist
2 months ago
UK, UK, United Kingdom Rowland Talent Solutions Full timeWe are currently looking for Senior Analytical Development Chemist to join a growing pharmaceutical R&D company in the South Wales.As a Senior Analytical Chemist, you will lead projects using your scientific expertise to solve analytical problems.You will be experienced in developing & validating analytical methods for novel compounds including HPLC, UPL, GC...