Head of Bioinformatics
2 weeks ago
**VACANCY - HEAD OF BIOINFORMATICS - TRANSLATIONAL GENOMICS**
Enhanc3D Genomics is a functional genomics spinout company from the Babraham Institute (Cambridge, UK) leveraging a disruptive technology to profile three-dimensional (3D) genome folding at high resolution.
Enhanc3D Genomics is an innovative and dynamic company with diverse and highly engaged staff. We believe in fostering great teamwork to maximise our collective skills and experience. We are passionate about realising the power of 3D genomics by developing new cutting-edge technologies for therapeutic discoveries.
**Role Profile**
You should be an organised professional with exceptional interpersonal and communication skills, enabling you to successfully operate in a business environment where confidentiality and discretion are paramount.
**Key Accountabilities**
- Lead on bioinformatics, biostatistics and visualisation programmes
- Develop innovative strategies for EG’s target discovery / biomarker discovery programmes, including assessment, benchmarking and theoretical development of EG’s statistical algorithms and methodology, as well as contribute to efficient computational implementations.
- Contribute and oversee scientific design both for technology development and biological insight end-points
- Produce professional reporting outputs for internal research and external collaborations.
- Work across teams and proactively engage in knowledge sharing and peer support, including training
- Line management
**Required Skills and Abilities**
- Track record of research in bioinformatics, biostatistics, genomics
- Experience and strong knowledge of Machine Learning / Deep Learning, SciML (Scientific Machine Learning)
- Excellent knowledge of two of Julia, Python and R. Proficient with common data science libraries/toolkits such as Julia data science libraries, Pandas, SciKit-Learn, Numpy, Keras etc.
- Experience with Next Generation Sequencing platforms and / or OMICS datasets
- Familiarity with common bioinformatic databases and tools
- Knowledge of version control and collaborating with developers using GitHub
- Excellent oral and written communication skills
- Excellent organizational and record keeping skills
- Programming and statistical data analysis and visualisation experience in R or Python with one or more common ML frameworks (Tensorflow, PyTorch, etc )
- Experience with variant calling, exome/WGS pipelines or other high-throughput genomics workflows
- Good knowledge of biomarker discovery / target discovery
- Ability to deliver quick wins alongside implementing more advanced modelling techniques
- Line management experience
**Desired Qualifications and Experience**
- Experience with and understanding of Hi-C, capture Hi-C, HiChIP
- A social personality that contributes to an open, positive, collaborative working climate, and a strong desire to drive personal development
- Proven experience of working in a fast-paced research-driven commercial environment or in collaboration with industry
- A strategic, inquisitive and innovative mindset with the ability to sense commercial opportunities in our data and exploit accordingly
- Delivery skills with the ability to work well under pressure in an agile environment
- Experience with pipeline development and software virtualisation (e.g. docker, singularity)
-
Research Assistant Gottgens Lab
16 hours ago
Cambridge, United Kingdom University of Cambridge Full timeApplications are invited for the position of Research Assistant to join the group of Professor Bertie Gottgens within The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute and Department of Haematology on the Cambridge Biomedical Campus. The post holder will be expected to participate in the design and planning of experiments. They...
-
Research Assistant/postdoctoral Research Associate
18 hours ago
Cambridge, United Kingdom University of Cambridge Full timeThe University of Cambridge is seeking a highly motivated Research Assistant or Postdoctoral Research Associate to join the laboratories of Professor Ian Goodfellow and Dr Jenny Molloy on an exciting Wellcome Trust funded project focused on putting genomic surveillance at the heart of outbreak response. The ARTIC Network is a global initiative aimed at...
-
Cambridge, United Kingdom University of Cambridge Full time**Do you have great analytical and IT skills? Interested in a role aiming to improve lives? Looking for your next challenge?** **About NIHR BioResource**: Our mission is to facilitate human health research and its transformation into medical practice. NIHR BioResource is a unique and powerful resource for studying disease mechanisms and investigating the...
-
Senior Research Associate
1 week ago
Cambridge, United Kingdom University of Cambridge Full timeApplications are invited for a Senior Statistical Geneticist to join the Genomics and Bioinformatics Core (GBC) within the Institute of Metabolic Science - Metabolic Research Laboratories at the Clinical School, University of Cambridge. The GBC provides analytical and data management support to research groups within the Metabolic Research Laboratories...
-
Senior Teaching Associate
6 days ago
Cambridge, United Kingdom University of Cambridge Full timeSenior Teaching Associate (Part Time, Fixed Term) Join to apply for the Senior Teaching Associate (Part Time, Fixed Term) role at University of Cambridge. Applications are invited for the position of Senior Teaching Associate, Pathogen Genomics and International Projects, to be based within the Centre for Research Informatics Training (CRIT) in central...
-
Research Associate
2 weeks ago
Cambridge, United Kingdom University of Cambridge Full timeFixed-term: The funds for this post are available for 1 year in the first instance. Proteins are the fundamental building blocks of the human body. Prof. Knowles' research group has developed a wide range of experimental and computational methods to better understand and predict protein behaviour. A key focus has been on developing approaches that can probe...
-
Pathogen Genomics Training Lead
6 days ago
Cambridge, United Kingdom University of Cambridge Full timeA prestigious educational institution is seeking a Senior Teaching Associate on a part-time and fixed-term basis in Cambridge. This role involves developing and delivering training courses in bioinformatics while collaborating with local trainers to enhance the program. The successful candidate will also engage in research to inform teaching practices and...
-
Research Associate
3 days ago
Cambridge, United Kingdom University of Cambridge Full timeExperience in in vivo experimentation with rodents, RNA sequencing (or other high-throughput technologies), bioinformatic analysis, and the handling of large datasets is essential. Proficiency in ex vivo tissue analysis, cell and organoid culture, and gene targeting (e.g., CRISPR/Cas9) is highly desirable. Additional experience in animal husbandry,...
-
Postdoctoral Scientist: RNA-Seq
1 week ago
Cambridge, United Kingdom MRC Laboratory of Molecular Biology Full timeA leading research institution in Cambridge is seeking a postdoctoral scientist to investigate non-canonical transcription and supercoiling in differentiation. Candidates should have a PhD in a relevant biological field or expect to complete one soon, along with experience in advanced bioinformatics and wet lab skills. The position offers a supportive...
-
Research Associate
1 week ago
Cambridge, United Kingdom University of Cambridge Full timeIn the Ali Group, we investigate how the multicellular spatial organisation underpins breast cancer. We use single cell proteomics of tissues (imaging mass cytometry) in combination with quantitative analysis to understand tumours as complex, dynamic heterocellular ecosystems. We are recruiting a Research Associate with bioinformatics experience to join the...
