Research Assistant in Neuroepigenomics

Job number

**MED04983**
- Faculties

**Faculty of Medicine**
- Salary or Salary range

**£43,003 - £46,297 per annum**
- Location/campus

**White City Campus - On site only**
- Contract type work pattern

**Full time - Fixed term**
- Posting End Date

**3 Jan 2025**
We are seeking to appoint a Research Assistant in Neuroepigenomics in Dr Nott’s research group
**About the role**:
We are seeking to appoint a **Research Assistant in Neuroepigenomics** in Dr Nott’s research group focusing on understanding how the epigenome regulates brain cell type gene expression programs during ageing and disease. You will lead one or more projects characterising the epigenome of brain vascular and immune cell-types for the interpretation of disease susceptibility. You will contribute to the design and analysis of large-scale ‘omics datasets with a primary focus on analysis of the epigenome and chromatin architecture to address major research questions relevant to dementia.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Alzheimer’s, Parkinson’s, and motor neuron disease (MND). The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages. However, due to major advances in our understanding of the biology of these diseases, the scientific field is at a tipping point, with the next decade promising to deliver transformative breakthroughs in therapies and a new era of predictive, preventative, and precision medicine for neurodegenerative conditions. The UK is well placed to play a leading role in this revolution due to its scientific strengths in the field, led by the UK Dementia Research Institute (UK DRI) working with our world-class, university-based centres. We are a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia. Our principal funder is the Medical Research Council (MRC).

**What you would be doing**:
You will use next-generation sequencing data from patient-derived brain tissue and stem cell model systems to identify signalling pathways and transcription factors dysregulated in brain diseases with a focus on Alzheimer’s disease and vascular-associated dementias. You will use genomic datasets that may include RNA-seq, ChIP-seq, CUT&Tag, ATAC-seq, capture-based HiC, and single-cell/nuclei datasets.

**What we are looking for**:

- You will be highly motivated with demonstrable experience in computational genomics and statistical modelling.
- You will work closely with experimentalists, where you will be responsible for data analysis and visualization as well as implementing new computational methods for processing and analysis of large-scale omics data.
- To promote the reproducibility of research, the postholder will be expected to maintain their code on depositories such as GitHub, develop containers and write workflows.**

**What we can offer you**:
This role is based in the Department of Brain Sciences and is part of the UK Dementia Research Institute. You will join a busy, multidisciplinary research laboratory based at Imperial’s White City Campus in west London. Research Assistants enjoy excellent career development opportunities, including:

- Access to a range of cutting-edge technologies
- Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’
- A network of computational researchers
- The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
- Grow your career: Gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression
- Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).

**Further information**:
This role is offered full time, initially until 31 March 2028, based at our White City Campus.

You will benefit from an active research (and social) environment in the Department of Brain Sciences, with additional research labs in the Burlington Danes Building on the nearby Hammersmith Campus.

Imperial is one of the UK’s most international universities and welcomes staff from all backgrounds and from all over the world.

**Available documents**:

- Attached documents are available under links. Clicking a document link will initialize its download.
- Download: Employee Benefits Booklet.Pdf
- Download: Job Description Research Assistant MED04983.Pdf

- Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with th