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Senior Bioinformatician
2 weeks ago
Company Description
Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines. Our pipeline includes Bicycle® Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need. Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.
**Culture** is key and all Bicycle employees actively embrace and role model our company values:
- We are **Adventurous**. It’s the way to deliver extraordinary results for our patients.
- We are **Dedicated to our Mission**. You can’t change the world if you don’t have determination.
- We are **One Team**. We only succeed when we work together.
**Job Description**:
As our team in the UK expands, we have created an exciting new opportunity for a Senior Bioinformatician to join our UK team. We are looking for an senior bioinformatician with experience in data wrangling and visualisation, extensive knowledge of bioinformatic databases, algorithm and pipeline development. They will have the opportunity to positively impact a broad spectrum of activities at the company to guide and further the work of our scientists. This individual will be comfortable at taking the lead on projects in a highly collaborative global work environment. For example, they will work on project to establish analysis frameworks, develop novel algorithms and report findings for our lead discovery and hit optimisation teams and support our oncology teams in identifying potential new targets for our proprietary Bicycle® peptide.
**Key Responsibilities**:
- Develop analysis frameworks and algorithms.
- Develop bioinformatics workflows and visualisations for protein sequence analysis and annotation.
- Design new software to disseminate functional assay data across multi-discipline teams.
- Develop algorithms and web apps for hit finding and optimisation.
- Help the Discovery team mine and visualise peptide sequencing data alongside functional data to enable information sharing between teams.
- Work with proprietary data platforms to enhance their function & capabilities e.g. better aligning/identification of sequence motifs, annotate sequences with information and generate graphical representation of data to aid interpretation.
- Generate actionable biological insights with reports or visualisations
- Support new target discovery
- Contribute to the analysis of multi-omics datasets and platforms beyond the above.
- Support the development in-house web apps that deliver the above.
Data wrangling and visualisation with propriety data sets and platforms beyond the above.
- Work across all scientific disciplines to understand their needs and requirements.
Qualifications**
Essential**:
- Extensive experience in bioinformatics, data science or equivalent.
- Demonstratable experience in framework anaylsis and development
- Hands-on programming experience in Python and / or R.
In-depth knowledge of proteins, cell or cancer biology.
- Experience with analysing a variety of omics datasets, e.g. biomarker, phenotypic, lead discovery.
Experience in sequence analysis (protein, peptide and NGS/Sanger genomic data sets).
**Desirable**:
- Experience in a drug discovery or biotech/pharmaceutical environment.
- Demonstrable experience in SQL.
- Data interpretation and visualisation methodologies.
- Knowledge in various statistics methods, prediction models and machine learning algorithms.
- Experience with ELN software such as Dotmatics
Additional Information
- State-of-the-art campus environment
- Competitive reward including annual company bonus
- 28 days annual leave in addition to bank holidays, plus option to buy up to 5 additional days
- Employer contribution to pension
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover
- Health Cash Plan
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
- Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status._
