Research Associate

2 days ago

White City, United Kingdom Autolus Ltd Full time

Role Summary

We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell engineering targets to develop and improve CAR T cell therapy.

This work will be performed in close collaboration with the wider Autolus R&D teams and successful applicants will work within a wider context of translational and cell manufacturing divisions. Rapid translation to clinical testing is a key motivation of the company. This is a unique opportunity to work at the forefront of immunotherapy in rapidly moving and truly multi-disciplinary field.

Key Responsibilities
- Mammalian cell culture techniques including aseptic work with multiple different cell lines and culture types.
- Molecular biology techniques including PCR, cloning, DNA analysis, modelling of cloning using appropriate software (snapgene etc).
- Characterisation of antibody and CAR T cell performance including;
- Protein analyses techniques; _Purification, ELISA, Biacore SPR, SEC chromatography, DSF etc._
- Cell analysis techniques; _Cell culture, flow cytometry, Incucyte, cytokine assays, cytotoxicity assays. _
- Clear and concise documentation of laboratory findings in electronic lab notebook.
- Plan and execute experiments with conflicting timelines.
- Interpret complex data sets using statistics packages and present conclusions concisely including in presentations to R&D teams and VP/CSO.
- Any other duties as required following consultation with the post holder.

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