Research Fellow
5 days ago
**Research Fellow**:
**Do you have a background in cancer biology, cancer immunotherapy or virology? Do you want to further your research career in one of the UK’s leading research-intensive Universities?**
**Assessment of oncolytic virus therapy using patient-derived Ewing Sarcoma models**
We are seeking a post-doctoral research fellow to work on a project investigating virus-based treatments of Ewing Sarcoma. This is a joint project between the labs of Dr Fiona Errington-Mais, Professor Sue Burchill and Professor Graham Cook in the School of Medicine. This project will use patient-derived Ewing Sarcoma cell cultures and a range of cell biology, immunological and computational methods to explore the therapeutic potential of oncolytic viruses against Ewing Sarcoma.
Cancer-killing, or “oncolytic” viruses are increasingly used to evoke therapeutic responses in cancer patients because of their multi-modal mechanism of action. Oncolytic viruses can directly kill cancer cells by preferentially replicating in cancer cells (not normal cells) and can activate our immune system to kill cancer cells, thereby acting as a cancer immunotherapy. Cancer immunotherapies are showing increasing promise for the treatment of otherwise incurable malignancies. This project, which is funded by Sarcoma UK, will identify oncolytic viruses that directly kill Ewing Sarcoma cells, explore biomarkers of response, and establish the potential role for oncolytic virus activated natural killer (NK) cells for therapy.
**To explore the post further or for any queries you may have, please contact**:
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