Clinical Fellow

ORGANISATIONAL ARRANGEMENTSThis post is for 40 hours per week to provide medical support to the Advanced Immunotherapy and Cell Therapy Team (AICT) by primarily acting as co-investigator on early phase clinical trials. The role has the following accountabilities: AICT team led by Prof. Fiona Thistlethwaite The interactions for this role include (but not limited to) the following: Advanced Immunotherapy and Cell Therapy Team Clinician, Clinical Fellows, Clinical Trial Pharmacists, Research Nurses, Healthcare Assistants, Clinical Trial Coordinators, Data Managers, Medical Secretaries, Clinical Trials Clerk, Translational Trial Facilitators, Investigator led study team, students. Role PurposeThe Christie NHS Foundation Trust is one of the largest Cancer Centres in Europe covering a large population in North West England and seeing more than 14,000 new patients each year.
The hospital is a designated teaching hospital of the University of Manchester and is the focal point of the Regional Cancer Network. It is also a CRUK designated major cancer research centre and combined with the Cancer Research UK Manchester Institute and the University of Manchester comprises the Manchester Cancer Research Centre. The Advanced Immunotherapy and Cell Therapy Team is specifically designed to facilitate delivery of complex and innovative therapies emerging in oncology. Facilities include inpatient beds, outpatient suites, trials pharmacy, laboratory and an administrative floor with short-term archiving, seminar room and monitoring rooms for external trials monitors.
Clinical research and service work is closely integrated with laboratory research. There are close links with the Cancer Research UK Manchester Institute which provide GCLP compliant laboratories. This together with the world class Biobank have strengthened and complemented this clinical development. This is an exceptional opportunity in the Advanced Immunotherapy and Cell Therapy Team.
We seek an ambitious, innovative individual to provide medical support to the consultants by primarily acting as co-investigator on a growing portfolio of early phase cell therapy and complex immunotherapy clinical trials. You will join a highly motivated and empowered workforce to increase research capacity and deliver innovative early phase research in compliance with Good Clinical Practice (ICH-GCP) and Trust policy. You will be based within AICT, providing medical support to the consultants by primarily acting as co-investigator on the portfolio of complex trials. With consultant oversight, you will be responsible for seeing new referrals, follow-ups and for managing the patient throughout all aspects of their trial experience.
There will be opportunities to work with our broader Experimental Cancer Medicine Team (ECMT) which has a well-established and regular molecular tumour board meeting supporting both local and national studies. You will take an active role in these meetings gaining valuable experience in using these data to identify and define suitable trial options for patients. You will have the opportunity to be involved in audit, writing papers and reviews and there is the potential to present research work at local, national, or international meetings. This is a 10 session non-training post (on the salary scale MN37, point dependent on experience) funded through The Christie NHS Foundation Trust for up to 2 years.
**RESEARCH**: A diverse range of clinical research trials are in progress and, following training, the post holder will be expected to participate in these studies as a co-/sub-investigator. These include cellular therapy and bispecific antibody early phase trials.You will be involved in managing all aspects of trial patients, across a diverse range of solid tumours, through new patient consultation, consent and screening patients and reviewing patients at follow-up appointments. Primarily, patients are seen in the outpatient setting but with some inpatient cover. The appointee is required to attend 5 trial outpatient clinics per week (see indicative timetable).You will be expected to attend Safety Review Committee meetings (usually remotely) to discuss trial patients.
This will involve close liaison with the trial Principal Investigators, referring consultant body across the Trust and other members of the team. In addition, you will interface with external stakeholders such as CROs and pharmaceutical sponsors.You will be expected to attend monthly molecular tumour board meetings to discuss trial patients and to agree opportunities for patients to enroll in early phase trials. PROTOCOLS: You will be expected to undertake the administrative duties associated with the care of their patients. You will be encouraged to harness opportunities to be involved in the development and planning of new studies.
**PROFESSIONAL DEVELOPMENT**: You will maintain a level of continuing professional development consistent with the recommendations of the Royal College of Physici